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The analysis of secondary quantitative data extracted from high-resolution synchrotron X-ray computed tomography scans represents a significant challenge for users. While a number of methods have been introduced for processing large…

Recent years have seen significant efforts to adopt Artificial Intelligence (AI) in healthcare for various use cases, from computer-aided diagnosis to ICU triage. However, the size of AI models has been rapidly growing due to scaling laws…

We propose a new model for digital pathology segmentation, based on the observation that histopathology images are inherently symmetric under rotation and reflection. Utilizing recent findings on rotation equivariant CNNs, the proposed…

Pathology image segmentation is crucial in computational pathology for analyzing histological features relevant to cancer diagnosis and prognosis. However, current methods face major challenges in clinical applications due to limited…

Due to the complexity of the human body, most diseases present a high inter-personal variability in the way they manifest, i.e. in their phenotype, which has important clinical repercussions - as for instance the difficulty in defining…

Deep learning has recently gained popularity in digital pathology due to its high prediction quality. However, the medical domain requires explanation and insight for a better understanding beyond standard quantitative performance…

In this survey paper, we review recent uses of convolution neural networks (CNNs) to solve inverse problems in imaging. It has recently become feasible to train deep CNNs on large databases of images, and they have shown outstanding…

Image segmentation is crucial in many computational pathology pipelines, including accurate disease diagnosis, subtyping, outcome, and survivability prediction. The common approach for training a segmentation model relies on a pre-trained…

We present highly efficient algorithms for performing forward and backward propagation of Convolutional Neural Network (CNN) for pixelwise classification on images. For pixelwise classification tasks, such as image segmentation and object…

The realm of medical image diagnosis has advanced significantly with the integration of computer-aided diagnosis and surgical systems. However, challenges persist, particularly in achieving precise image segmentation. While deep learning…

Convolutional Neural Networks (CNNs) are the state-of-the-art algorithms for the processing of images. However the configuration and training of these networks is a complex task requiring deep domain knowledge, experience and much trial and…

The combination of data analysis methods, increasing computing capacity, and improved sensors enable quantitative granular, multi-scale, cell-based analyses. We describe the rich set of application challenges related to tissue…

Prostate cancer is one of the most common causes of cancer deaths in men. There is a growing demand for noninvasively and accurately diagnostic methods that facilitate the current standard prostate cancer risk assessment in clinical…

Representation learning for Whole Slide Images (WSIs) is pivotal in developing image-based systems to achieve higher precision in diagnostic pathology. We propose a two-stage framework for WSI representation learning. We sample relevant…

Convolutional neural networks (CNNs) are a standard tool for computer vision tasks such as image classification. However, typical model architectures may result in the loss of topological information. In specific domains such as…

Neural networks in the real domain have been studied for a long time and achieved promising results in many vision tasks for recent years. However, the extensions of the neural network models in other number fields and their potential…

We present compositional nearest neighbors (CompNN), a simple approach to visually interpreting distributed representations learned by a convolutional neural network (CNN) for pixel-level tasks (e.g., image synthesis and segmentation). It…

We present a simple yet general and efficient approach to representation of computational meshes. Meshes are represented as sets of mesh entities of different topological dimensions and their incidence relations. We discuss a…

Machine learning-based analysis of medical images often faces several hurdles, such as the lack of training data, the curse of dimensionality problem, and the generalization issues. One of the main difficulties is that there exists…

Recent advances in whole slide imaging (WSI) technology have led to the development of a myriad of computer vision and artificial intelligence (AI) based diagnostic, prognostic, and predictive algorithms. Computational Pathology (CPath)…