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Medicinal synergy prediction is a powerful tool in drug discovery and development that harnesses the principles of combination therapy to enhance therapeutic outcomes by improving efficacy, reducing toxicity, and preventing drug resistance.…

计算工程、金融与科学 · 计算机科学 2024-11-26 Jiawei Wu , Jun Wen , Mingyuan Yan , Anqi Dong , Shuai Gao , Ren Wang , Can Chen

How should we gather information to make effective decisions? We address Bayesian active learning and experimental design problems, where we sequentially select tests to reduce uncertainty about a set of hypotheses. Instead of minimizing…

机器学习 · 计算机科学 2014-02-25 Shervin Javdani , Yuxin Chen , Amin Karbasi , Andreas Krause , J. Andrew Bagnell , Siddhartha Srinivasa

Cellular Electron Cryo-Tomography (CECT) is a powerful imaging technique for the 3D visualization of cellular structure and organization at submolecular resolution. It enables analyzing the native structures of macromolecular complexes and…

定量方法 · 定量生物学 2018-05-16 Chang Liu , Xiangrui Zeng , Ruogu Lin , Xiaodan Liang , Zachary Freyberg , Eric Xing , Min Xu

In the point set embeddability problem, we are given a plane graph $G$ with $n$ vertices and a point set $S$ with $n$ points. Now the goal is to answer the question whether there exists a straight-line drawing of $G$ such that each vertex…

计算几何 · 计算机科学 2020-05-13 Tanaeem M. Moosa , M. Sohel Rahman

Many complex systems involve interactions between more than two agents. Hypergraphs capture these higher-order interactions through hyperedges that may link more than two nodes. We consider the problem of embedding a hypergraph into…

社会与信息网络 · 计算机科学 2023-01-06 Xue Gong , Desmond J. Higham , Konstantinos Zygalakis

When we try to solve a system of linear equations, we can consider a simple iterative algorithm in which an equation including only one variable is chosen at each step, and the variable is fixed to the value satisfying the equation. The…

离散数学 · 计算机科学 2015-06-03 Ryuhei Mori , Osamu Watanabe

We consider the problem of embedding the nodes of a hypergraph into Euclidean space under the assumption that the interactions arose through closeness to unknown hyperedge centres. In this way, we tackle the inverse problem associated with…

社会与信息网络 · 计算机科学 2025-09-11 Francesco Zigliotto , Desmond J. Higham

The detection of nuclei and cells in histology images is of great value in both clinical practice and pathological studies. However, multiple reasons such as morphological variations of nuclei or cells make it a challenging task where…

计算机视觉与模式识别 · 计算机科学 2021-06-28 Yibao Sun , Xingru Huang , Huiyu Zhou , Qianni Zhang

Identifying symmetries in data sets is generally difficult, but knowledge about them is crucial for efficient data handling. Here we present a method how neural networks can be used to identify symmetries. We make extensive use of the…

计算物理 · 物理学 2020-03-31 Sven Krippendorf , Marc Syvaeri

Calcium imaging has emerged as a workhorse method in neuroscience to investigate patterns of neuronal activity. Instrumentation to acquire calcium imaging movies has rapidly progressed and has become standard across labs. Still, algorithms…

定量方法 · 定量生物学 2019-06-03 Quico Spaen , Dorit S. Hochbaum , Roberto Asín-Achá

Graph spectral analysis can yield meaningful embeddings of graphs by providing insight into distributed features not directly accessible in nodal domain. Recent efforts in graph signal processing have proposed new decompositions-e.g., based…

Traditional approaches to classify the political bias of news articles have failed to generate accurate, generalizable results. Existing networks premised on CNNs and DNNs lack a model to identify and extrapolate subtle indicators of bias…

神经与进化计算 · 计算机科学 2022-07-27 Agastya Sridharan , Natarajan S

Atom segmentation and localization, noise reduction and deblurring of atomic-resolution scanning transmission electron microscopy (STEM) images with high precision and robustness is a challenging task. Although several conventional…

材料科学 · 物理学 2021-02-23 Ruoqian Lin , Rui Zhang , Chunyang Wang , Xiao-Qing Yang , Huolin L. Xin

This study establishes a benchmark for Caenorhabditis elegans neuron classification, comparing four graph methods (GCN, GraphSAGE, GAT, GraphTransformer) against four non-graph methods (Logistic Regression, MLP, LOLCAT, NeuPRINT). Using the…

神经元与认知 · 定量生物学 2026-03-04 Jingqi Lu , Keqi Han , Yun Wang , Lu Mi , Carl Yang

Modern single-cell flow and mass cytometry technologies measure the expression of several proteins of the individual cells within a blood or tissue sample. Each profiled biological sample is thus represented by a set of hundreds of…

机器学习 · 计算机科学 2022-06-29 Siyuan Shan , Vishal Baskaran , Haidong Yi , Jolene Ranek , Natalie Stanley , Junier Oliva

Graph Neural Networks (GNNs) have proven to be powerful in many graph-based applications. However, they fail to generalize well under heterophilic setups, where neighbor nodes have different labels. To address this challenge, we employ a…

机器学习 · 计算机科学 2023-04-13 Yoonhyuk Choi , Jiho Choi , Taewook Ko , Chong-Kwon Kim

We propose a method to match anatomical locations between pairs of medical images in longitudinal comparisons. The matching is made possible by computing a descriptor of the query point in a source image based on a hierarchical sparse…

图像与视频处理 · 电气工程与系统科学 2023-09-26 Halid Ziya Yerebakan , Yoshihisa Shinagawa , Mahesh Ranganath , Simon Allen-Raffl , Gerardo Hermosillo Valadez

Reconstructing a map of neuronal connectivity is a critical challenge in contemporary neuroscience. Recent advances in high-throughput serial section electron microscopy (EM) have produced massive 3D image volumes of nanoscale brain tissue…

Pap smear testing has been widely used for detecting cervical cancers based on the morphology properties of cell nuclei in microscopic image. An accurate nuclei segmentation could thus improve the success rate of cervical cancer screening.…

计算机视觉与模式识别 · 计算机科学 2019-05-15 Jie Zhao , Quanzheng Li , Xiang Li , Hongfeng Li , Li Zhang

Multi-hop machine reading comprehension is a challenging task in natural language processing as it requires more reasoning ability across multiple documents. Spectral models based on graph convolutional networks have shown good inferring…

计算与语言 · 计算机科学 2023-07-24 Peng Gao , Feng Gao , Peng Wang , Jian-Cheng Ni , Fei Wang , Hamido Fujita