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Identification of unexpectedly high values in a time series is useful for epidemiologists, economists, and other social scientists interested in the effect of an exposure spike on an outcome variable. However, the best method to identify…

应用统计 · 统计学 2018-01-25 Dana E. Goin , Jennifer Ahern

Sampling considerations limit the experimental conditions under which information theoretic analyses of neurophysiological data yield reliable results. We develop a procedure for computing the full temporal entropy and information of…

生物物理 · 物理学 2009-11-06 Simon R. Schultz , Stefano Panzeri

Bidimensional spiking models currently gather a lot of attention for their simplicity and their ability to reproduce various spiking patterns of cortical neurons, and are particularly used for large network simulations. These models…

数值分析 · 计算机科学 2012-11-07 Jonathan Touboul

Non-invasive observation of spatiotemporal neural activity of large neural populations distributed over entire brains is a longstanding goal of neuroscience. We developed a real-time volumetric and multispectral optoacoustic tomography…

Information processing in the brain is conducted by a concerted action of multiple neural populations. Gaining insights in the organization and dynamics of such populations can best be studied with broadband intracranial recordings of…

Two elements of neural information processing have primarily been proposed: firing rate and spike timing of neurons. In the case of synaptic plasticity, although spike-timing-dependent plasticity (STDP) depending on presynaptic and…

神经元与认知 · 定量生物学 2020-01-14 Katsuhiko Hata , Osamu Araki , Osamu Yokoi , Tatsumi Kusakabe , Yoshio Yamamoto , Susumu Ito , Tetsuro Nikuni

Spiking neuronal networks are usually simulated with three main simulation schemes: the classical time-driven and event-driven schemes, and the more recent hybrid scheme. All three schemes evolve the state of a neuron through a series of…

神经元与认知 · 定量生物学 2018-01-24 Jeyashree Krishnan , PierGianLuca Porta Mana , Moritz Helias , Markus Diesmann , Edoardo Di Napoli

Neuromorphic applications emulate the processing performed by the brain by using spikes as inputs instead of time-varying analog stimuli. Therefore, these time-varying stimuli have to be encoded into spikes, which can induce important…

神经与进化计算 · 计算机科学 2024-12-30 Ahmad El Ferdaoussi , Eric Plourde , Jean Rouat

Repeated occurrences of serial firing sequences of a group of neurons with fixed time delays between neurons are observed in many experiments involving simultaneous recordings from multiple neurons. Such temporal patterns are potentially…

神经元与认知 · 定量生物学 2008-09-01 C. O. Diekman , P. S. Sastry , K. P. Unnikrishnan

One of the main current issues in Neurobiology concerns the understanding of interrelated spiking activity among multineuronal ensembles and differences between stimulus-driven and spontaneous activity in neurophysiological experiments.…

神经元与认知 · 定量生物学 2017-10-13 Ludmila Brochini , Antonio Galves , Pierre Hodara , Guilherme Ost , Christophe Pouzat

In timing-based neural codes, neurons have to emit action potentials at precise moments in time. We use a supervised learning paradigm to derive a synaptic update rule that optimizes via gradient ascent the likelihood of postsynaptic firing…

神经元与认知 · 定量生物学 2007-05-23 Jean-Pascal Pfister , Taro Toyoizumi , David Barber , Wulfram Gerstner

Studies of motor control have almost universally examined firing rates to investigate how the brain shapes behavior. In principle, however, neurons could encode information through the precise temporal patterning of their spike trains as…

神经元与认知 · 定量生物学 2014-04-15 Claire Tang , Diala Chehayeb , Kyle Srivastava , Ilya Nemenman , Samuel Sober

In this paper we present a simple microscopic stochastic model describing short term plasticity within a large homogeneous network of interacting neurons. Each neuron is represented by its membrane potential and by the residual calcium…

概率论 · 数学 2020-01-29 Antonio Galves , Eva Löcherbach , Christophe Pouzat , Errico Presutti

There is an increasing demand to process streams of temporal data in energy-limited scenarios such as embedded devices, driven by the advancement and expansion of Internet of Things (IoT) and Cyber-Physical Systems (CPS). Spiking neural…

神经与进化计算 · 计算机科学 2020-07-08 Haowen Fang , Amar Shrestha , Qinru Qiu

With the rapid growth of neuroimaging technologies, a great effort has been dedicated recently to investigate the dynamic changes in brain activity. Examples include time course calcium imaging and dynamic brain functional connectivity. In…

统计方法学 · 统计学 2020-08-31 Wei Hu , Tianyu Pan , Dehan Kong , Weining Shen

Neural spike trains, which are sequences of very brief jumps in voltage across the cell membrane, were one of the motivating applications for the development of point process methodology. Early work required the assumption of stationarity,…

应用统计 · 统计学 2011-08-01 Robert E. Kass , Ryan C. Kelly , Wei-Liem Loh

Recent work suggests that large-scale, multi-animal modeling can significantly improve neural recording analysis. However, for functional calcium traces, existing approaches remain task-specific, limiting transfer across common neuroscience…

定量方法 · 定量生物学 2026-04-09 Xinhong Xu , Yimeng Zhang , Qichen Qian , Yuanlong Zhang

We demonstrate the efficacy of a new spike-sorting method based on a Markov Chain Monte Carlo (MCMC) algorithm by applying it to real data recorded from Purkinje cells (PCs) in young rat cerebellar slices. This algorithm is unique in its…

定量方法 · 定量生物学 2011-11-10 Matthieu Delescluse , Christophe Pouzat

Primary vestibular neurons are categorized as either regularly or irregularly firing afferents that use rate and temporal sensory encoding strategies, respectively. While many factors influence firing in these neurons, recent work in…

神经元与认知 · 定量生物学 2021-08-03 Selina Baeza Loya

The adaptive leaky integrate-and-fire (ALIF) model is fundamental within computational neuroscience and has been instrumental in studying our brains $\textit{in silico}$. Due to the sequential nature of simulating these neural models, a…

神经与进化计算 · 计算机科学 2023-11-21 Luke Taylor , Andrew J King , Nicol S Harper