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Generalized linear mixed models (GLMM) are used for inference and prediction in a wide range of different applications providing a powerful scientific tool. An increasing number of sources of data are becoming available, introducing a…

统计计算 · 统计学 2019-03-19 Aliaksandr Hubin , Geir Storvik

This paper introduces a Bayesian framework that combines Markov chain Monte Carlo (MCMC) sampling, dimensionality reduction, and neural density estimation to efficiently handle inverse problems that (i) must be solved multiple times, and…

计算工程、金融与科学 · 计算机科学 2026-02-24 Giacomo Bottacini , Matteo Torzoni , Andrea Manzoni

Performing numerical integration when the integrand itself cannot be evaluated point-wise is a challenging task that arises in statistical analysis, notably in Bayesian inference for models with intractable likelihood functions. Markov…

统计计算 · 统计学 2020-06-17 Lawrence Middleton , George Deligiannidis , Arnaud Doucet , Pierre E. Jacob

Regression models for dichotomous data are ubiquitous in statistics. Besides being useful for inference on binary responses, these methods serve also as building blocks in more complex formulations, such as density regression, nonparametric…

统计方法学 · 统计学 2019-11-19 Daniele Durante

Missing data are often dealt with multiple imputation. A crucial part of the multiple imputation process is selecting sensible models to generate plausible values for incomplete data. A method based on posterior predictive checking is…

统计计算 · 统计学 2026-05-14 Mingyang Cai , Stef van Buuren , Gerko Vink

This paper describes a method for a model-based analysis of clinical safety data called multivariate Bayesian logistic regression (MBLR). Parallel logistic regression models are fit to a set of medically related issues, or response…

统计方法学 · 统计学 2012-10-02 William DuMouchel

Bayesian inference provides a methodology for parameter estimation and uncertainty quantification in machine learning and deep learning methods. Variational inference and Markov Chain Monte-Carlo (MCMC) sampling methods are used to…

机器学习 · 统计学 2024-08-27 Rohitash Chandra , Joshua Simmons

We discuss a shift in perspective from traditional approaches to breast cancer risk prediction: modelling families rather than individuals as unit of analysis. By investigating the latent familial risk underlying breast cancer diagnoses, we…

应用统计 · 统计学 2025-08-25 Maria Veronica Vinattieri , Marco Bonetti , Kamila Czene

When performing Bayesian data analysis using a general linear mixed model, the resulting posterior density is almost always analytically intractable. However, if proper conditionally conjugate priors are used, there is a simple two-block…

统计理论 · 数学 2017-11-21 Tavis Abrahamsen , James P. Hobert

Missing values exist in nearly all clinical studies because data for a variable or question are not collected or not available. Inadequate handling of missing values can lead to biased results and loss of statistical power in analysis.…

机器学习 · 计算机科学 2021-03-04 Narges Pourshahrokhi , Samaneh Kouchaki , Kord M. Kober , Christine Miaskowski , Payam Barnaghi

We propose a multiple imputation method based on principal component analysis (PCA) to deal with incomplete continuous data. To reflect the uncertainty of the parameters from one imputation to the next, we use a Bayesian treatment of the…

统计方法学 · 统计学 2015-08-20 Vincent Audigier , François Husson , Julie Josse

The article develops marginal models for multivariate longitudinal responses. Overall, the model consists of five regression submodels, one for the mean and four for the covariance matrix, with the latter resulting by considering various…

统计方法学 · 统计学 2020-12-18 Georgios Papageorgiou

Markov Chain Monte Carlo (MCMC) algorithms are frequently used to perform inference under a Bayesian modeling framework. Convergence diagnostics, such as traceplots, the Gelman-Rubin potential scale reduction factor, and effective sample…

We tackle the problem of multiscale regression for predictors that are spatially or temporally indexed, or with a pre-specified multiscale structure, with a Bayesian modular approach. The regression function at the finest scale is expressed…

统计方法学 · 统计学 2018-09-18 Michele Peruzzi , David B. Dunson

We propose a general framework using spike-and-slab prior distributions to aid with the development of high-dimensional Bayesian inference. Our framework allows inference with a general quasi-likelihood function. We show that highly…

统计理论 · 数学 2019-08-21 Yves Atchade , Anwesha Bhattacharyya

Background: Mendelian randomization (MR) is a useful approach to causal inference from observational studies when randomised controlled trials are not feasible. However, study heterogeneity of two association studies required in MR is often…

统计方法学 · 统计学 2021-12-16 Linyi Zou , Hui Guo , Carlo Berzuini

Based on structured data derived from large complex systems, we computationally further develop and refine a major factor selection protocol by accommodating structural dependency and heterogeneity among many features to unravel data's…

统计方法学 · 统计学 2022-09-07 Hsieh Fushing , Elizabeth Chou , Ting-Li Chen

For large model spaces, the potential entrapment of Markov chain Monte Carlo (MCMC) based methods with spike-and-slab priors poses significant challenges in posterior computation in regression models. On the other hand, maximum a posteriori…

统计方法学 · 统计学 2026-02-25 Shamriddha De , Joyee Ghosh

Bayesian models have become very popular over the last years in several fields such as signal processing, statistics, and machine learning. Bayesian inference requires the approximation of complicated integrals involving posterior…

统计计算 · 统计学 2021-07-20 Luca Martino , Víctor Elvira

If the conclusion of a data analysis is sensitive to dropping very few data points, that conclusion might hinge on the particular data at hand rather than representing a more broadly applicable truth. How could we check whether this…

统计方法学 · 统计学 2024-11-12 Tin D. Nguyen , Ryan Giordano , Rachael Meager , Tamara Broderick