相关论文: Adversarial Contrastive Pre-training for Protein S…

The parallels between protein sequences and natural language in their sequential structures have inspired the application of large language models (LLMs) to protein understanding. Despite the success of LLMs in NLP, their effectiveness in…

Recently, substantial progress has been made in language modeling by using deep neural networks. However, in practice, large scale neural language models have been shown to be prone to overfitting. In this paper, we present a simple yet…

Protein language models often take into consideration the alignment between a protein sequence and its textual description. However, they do not take structural information into consideration. Traditional methods treat sequence and…

Pre-trained Transformers are challenging human performances in many NLP tasks. The massive datasets used for pre-training seem to be the key to their success on existing tasks. In this paper, we explore how a range of pre-trained Natural…

Deep neural-network-based language models (LMs) are increasingly applied to large-scale protein sequence data to predict protein function. However, being largely black-box models and thus challenging to interpret, current protein LM…

Modern Protein Language Models (PLMs) apply transformer-based model architectures from natural language processing to biological sequences, predicting a variety of protein functions and properties. However, protein language has key…

This position paper proposes a novel approach to advancing NLP security by leveraging Large Language Models (LLMs) as engines for generating diverse adversarial attacks. Building upon recent work demonstrating LLMs' effectiveness in…

Protein language models (pLMs) pre-trained on vast protein sequence databases excel at various downstream tasks but often lack the structural knowledge essential for some biological applications. To address this, we introduce a method to…

Deep learning-based natural language processing (NLP) models, particularly pre-trained language models (PLMs), have been revealed to be vulnerable to adversarial attacks. However, the adversarial examples generated by many mainstream…

Unsupervised cross-lingual pretraining has achieved strong results in neural machine translation (NMT), by drastically reducing the need for large parallel data. Most approaches adapt masked-language modeling (MLM) to sequence-to-sequence…

Deep transformer neural network models have improved the predictive accuracy of intelligent text processing systems in the biomedical domain. They have obtained state-of-the-art performance scores on a wide variety of biomedical and…

We now have a rich and growing set of modeling tools and algorithms for inducing linguistic structure from text that is less than fully annotated. In this paper, we discuss some of the weaknesses of our current methodology. We present a new…

Protein language models (PLMs) learn contextual representations from protein sequences and are profoundly impacting various scientific disciplines spanning protein design, drug discovery, and structural predictions. One particular research…

The prediction of amyloidogenicity in peptides and proteins remains a focal point of ongoing bioinformatics. The crucial step in this field is to apply advanced computational methodologies. Many recent approaches to predicting…

This paper introduces diffusion protein language model (DPLM), a versatile protein language model that demonstrates strong generative and predictive capabilities for protein sequences. We first pre-train scalable DPLMs from…

Recent advancements in specialized large-scale architectures for training image and language have profoundly impacted the field of computer vision and natural language processing (NLP). Language models, such as the recent ChatGPT and GPT4…

As LLMs evolve, significant effort is spent on manually crafting prompts. While existing prompt optimization methods automate this process, they rely solely on learning from incorrect samples, leading to a sub-optimal performance.…

In recent years, NLP practitioners have converged on the following practice: (i) import an off-the-shelf pretrained (masked) language model; (ii) append a multilayer perceptron atop the CLS token's hidden representation (with randomly…

Large Language Models (LLMs) have revolutionized the field of Natural Language Processing (NLP) by automating traditional labor-intensive tasks and consequently accelerated the development of computer-aided applications. As researchers…

Considering the significance of proteins, computational protein science has always been a critical scientific field, dedicated to revealing knowledge and developing applications within the protein sequence-structure-function paradigm. In…