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In practice, digital pathology images are often affected by various factors, resulting in very large differences in color and brightness. Stain normalization can effectively reduce the differences in color and brightness of digital…

图像与视频处理 · 电气工程与系统科学 2024-07-17 Hongtao Kang , Die Luo , Li Chen , Junbo Hu , Tingwei Quan , Shaoqun Zeng , Shenghua Cheng , Xiuli Liu

Deep learning models that are trained on histopathological images obtained from a single lab and/or scanner give poor inference performance on images obtained from another scanner/lab with a different staining protocol. In recent years,…

图像与视频处理 · 电气工程与系统科学 2020-10-07 Harshal Nishar , Nikhil Chavanke , Nitin Singhal

Color inconsistency is an inevitable challenge in computational pathology, which generally happens because of stain intensity variations or sections scanned by different scanners. It harms the pathological image analysis methods, especially…

图像与视频处理 · 电气工程与系统科学 2022-03-01 Bingchao Zhao , Jiatai Lin , Changhong Liang , Zongjian Yi , Xin Chen , Bingbing Li , Weihao Qiu , Danyi Li , Li Liang , Chu Han , Zaiyi Liu

Stain normalization algorithms aim to transform the color and intensity characteristics of a source multi-gigapixel histology image to match those of a target image, mitigating inconsistencies in the appearance of stains used to highlight…

图像与视频处理 · 电气工程与系统科学 2024-07-15 Robert Jewsbury , Ruoyu Wang , Abhir Bhalerao , Nasir Rajpoot , Quoc Dang Vu

Performance of deep learning algorithms decreases drastically if the data distributions of the training and testing sets are different. Due to variations in staining protocols, reagent brands, and habits of technicians, color variation in…

计算机视觉与模式识别 · 计算机科学 2020-12-01 Abhijeet Patil , Mohd. Talha , Aniket Bhatia , Nikhil Cherian Kurian , Sammed Mangale , Sunil Patel , Amit Sethi

We propose a novel hematoxylin and eosin (H&E) stain normalization method based on a modified U-Net neural network architecture. Unlike previous deep-learning methods that were often based on generative adversarial networks (GANs), we take…

图像与视频处理 · 电气工程与系统科学 2022-11-11 Chi-Chen Lee , Po-Tsun Paul Kuo , Chi-Han Peng

Computer assisted diagnosis in digital pathology is becoming ubiquitous as it can provide more efficient and objective healthcare diagnostics. Recent advances have shown that the convolutional Neural Network (CNN) architectures, a…

图像与视频处理 · 电气工程与系统科学 2022-01-05 Sruthi Krishna , Suganthi S. S , Shivsubramani Krishnamoorthy , Arnav Bhavsar

Staining is essential in cell imaging and medical diagnostics but poses significant challenges, including high cost, time consumption, labor intensity, and irreversible tissue alterations. Recent advances in deep learning have enabled…

计算机视觉与模式识别 · 计算机科学 2025-04-15 Ziwang Xu , Lanqing Guo , Satoshi Tsutsui , Shuyan Zhang , Alex C. Kot , Bihan Wen

An important part of Digital Pathology is the analysis of multiple digitised whole slide images from differently stained tissue sections. It is common practice to mount consecutive sections containing corresponding microscopic structures on…

计算机视觉与模式识别 · 计算机科学 2018-11-06 Thomas Lampert , Odyssée Merveille , Jessica Schmitz , Germain Forestier , Friedrich Feuerhake , Cédric Wemmert

The rapid growth of digital pathology in recent years has provided an ideal opportunity for the development of artificial intelligence-based tools to improve the accuracy and efficiency of clinical diagnoses. One of the significant…

图像与视频处理 · 电气工程与系统科学 2024-03-08 Jack Breen , Kieran Zucker , Katie Allen , Nishant Ravikumar , Nicolas M. Orsi

Virtual stain transfer is a promising area of research in Computational Pathology, which has a great potential to alleviate important limitations when applying deeplearningbased solutions such as lack of annotations and sensitivity to a…

计算机视觉与模式识别 · 计算机科学 2022-10-19 Jelica Vasiljević , Friedrich Feuerhake , Cédric Wemmert , Thomas Lampert

The color appearance of a pathological image is highly related to the imaging protocols, the proportion of different dyes, and the scanning devices. Computer-aided diagnostic systems may deteriorate when facing these color-variant…

图像与视频处理 · 电气工程与系统科学 2025-06-25 Zheng Chen

Histopathology relies on the analysis of microscopic tissue images to diagnose disease. A crucial part of tissue preparation is staining whereby a dye is used to make the salient tissue components more distinguishable. However, differences…

图像与视频处理 · 电气工程与系统科学 2022-08-03 Haseeb Nazki , Ognjen Arandjelović , InHwa Um , David Harrison

Deep learning advances have revolutionized automated digital pathology analysis. However, differences in staining protocols and imaging conditions can introduce significant color variability. In deep learning, such color inconsistency often…

计算机视觉与模式识别 · 计算机科学 2025-10-09 Tianyue Xu , Yanlin Wu , Abhai K. Tripathi , Matthew M. Ippolito , Benjamin D. Haeffele

The diagnosis of cancer is mainly performed by visual analysis of the pathologists, through examining the morphology of the tissue slices and the spatial arrangement of the cells. If the microscopic image of a specimen is not stained, it…

图像与视频处理 · 电气工程与系统科学 2020-02-06 Pegah Salehi , Abdolah Chalechale

The variation in histologic staining between different medical centers is one of the most profound challenges in the field of computer-aided diagnosis. The appearance disparity of pathological whole slide images causes algorithms to become…

图像与视频处理 · 电气工程与系统科学 2024-04-05 Martin J. Hetz , Tabea-Clara Bucher , Titus J. Brinker

Histological staining is the gold standard for tissue examination in clinical pathology and life-science research, which visualizes the tissue and cellular structures using chromatic dyes or fluorescence labels to aid the microscopic…

医学物理 · 物理学 2023-03-07 Bijie Bai , Xilin Yang , Yuzhu Li , Yijie Zhang , Nir Pillar , Aydogan Ozcan

Deep learning is popularly used for analyzing pathology images, but variations in image properties can limit the effectiveness of the models. The study aims to develop a method that transfers the variability present in the training set to…

图像与视频处理 · 电气工程与系统科学 2024-09-12 M. Muneeb Arshad , Hasan Sajid , M. Jawad Khan

In recent years, deep neural networks (DNNs) have demonstrated remarkable performance in pathology applications, potentially even outperforming expert pathologists due to their ability to learn subtle features from large datasets. One…

图像与视频处理 · 电气工程与系统科学 2024-09-16 Siyu , Lin , Haowen Zhou , Richard J. Cote , Mark Watson , Ramaswamy Govindan , Changhuei Yang

Artistic style transfer is an image synthesis problem where the content of an image is reproduced with the style of another. Recent works show that a visually appealing style transfer can be achieved by using the hidden activations of a…

计算机视觉与模式识别 · 计算机科学 2016-12-14 Tian Qi Chen , Mark Schmidt
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