相关论文: A Time-Of-Flight-Based Reconstruction for Real-Tim…

In order to fully exploit the ballistic potential of particle therapy, we propose an online range monitoring concept based on high-resolution Time-Of-Flight (TOF)-resolved Prompt Gamma (PG) detection in a single proton counting regime. In a…

The accuracy of hadrontherapy treatment is currently limited by ion-range uncertainties. In order to fully exploit the potential of this technique, we propose the development of a novel system for online control of particle therapy, based…

We recently proposed a new approach for the real-time monitoring of particle therapy treatments with the goal of achieving high sensitivities on the particle range measurement already at limited counting statistics. This method extends the…

In the context of range monitoring for particle therapy, this study presents the first experimental results obtained with the TIARA detector using carbon-ion beams at the CNAO clinical center in Pavia, Italy. TIARA is based on the Prompt…

We developed a novel gamma-ray detection system (TIARA) for range monitoring in Particle Therapy. The system employs Cherenkov-based gamma-ray detection modules arranged around the target or patient, operated in time coincidence with a fast…

The major advantage of proton therapy over conventional radiotherapy is the dose deposition pattern, enabling precise coverage of the tumour volume while sparing nearby healthy tissues. However, accurate control of the proton beam range…

The Time-of-Flight (ToF) technique coupled with semiconductor-like detectors, as silicon carbide and diamond, is one of the most promising diagnostic methods for high-energy, high repetition rate, laser-accelerated ions allowing a full…

Objective. Prompt-gamma imaging encompasses several approaches for online monitoring of beam range or deposited dose distribution in proton therapy. We test one of the imaging techniques - a coded mask approach - both experimentally and via…

Intraoperative Gamma Probe (IPG) remains the current gold standard modality for sentinel lymph node identification and tumor removal in cancer patients. However, even alongside the optical dyes they do not meet with <5% false negative rates…

Proton therapy's full potential is limited by uncertainties that prevent optimal dose distribution. Monitoring techniques can reduce these uncertainties and enable adaptive treatment planning. Spatiotemporal Emission Reconstruction from…

Objective: Proton therapy is a precision-focused cancer treatment where accurate proton beam range monitoring is critical to ensure effective dose delivery. This can be achieved by prompt gamma detection with a Compton camera like the…

Objective: Real-time adaptive proton range verification systems based on produced neutrons require accurate information on their non-isotropic momentum distributions within short times, for which Monte Carlo (MC) methods are too…

Objective. The objective of the presented study was to evaluate the feasibility of a coded-mask (CM) gamma camera for real-time range verification in proton therapy, addressing the need for a precise and efficient method of treatment…

Time-of-flight magnetic resonance angiography (TOF-MRA) is one of the most widely used non-contrast MR imaging methods to visualize blood vessels, but due to the 3-D volume acquisition highly accelerated acquisition is necessary.…

Proton computed tomography (CT) is similar to x-ray CT but relies on protons rather than photons to form an image. In its most common operation mode, the measured quantity is the amount of energy that a proton has lost while traversing the…

Range uncertainties in proton therapy hamper treatment precision. Prompt gamma-rays were suggested 16 years ago for real-time range verification, and have already shown promising results in clinical studies with collimated cameras.…

Time-of-flight (ToF) measurements is a possible alternative to anti-scatter grids in computed tomography (CT). Simulations have shown a possible 75% reduction in the detrimental scattering contribution with a 100 ps FWHM timing resolution.…

Fast procedures for the beam quality assessment and for the monitoring of beam energy modulations during the irradiation are among the most urgent improvements in particle therapy. Indeed, the online measurement of the particle beam energy…

Time-of-flight positron emission tomography (TOF-PET) detectors exhibiting multiple coincidence time resolution (CTR) components, such as those induced by the mixing of Cherenkov and scintillation photons, have attracted increasing…

Time-of-flight (ToF) 3D imaging has a wealth of applications, from industrial inspection to movement tracking and gesture recognition. Depth information is recovered by measuring the round-trip flight time of laser pulses, which usually…