相关论文: Finite element modelling of in-stent restenosis
Modeling the spontaneous evolution of morphology in natural systems and its preservation by proportionate growth remains a major scientific challenge. Yet, it is conceivable that if the basic mechanisms of growth and the coupled kinetic…
Residual stress is ubiquitous and indispensable in most biological and artificial materials, where it sustains and optimizes many biological and functional mechanisms. The theory of volume growth, starting from a stress-free initial state,…
Coronary heart disease (CHD) remains a top reason of mortality worldwide. This study introduces a novel approach by integrating patient-specific Multi-slice CT scans into CAD models and employing a one-dimensional numerical framework to…
In this work, the finite elements method (FEM) is used to analyse the growth of fretting cracks. FEM can be favourably used to extract the stress intensity factors in mixed mode, a typical situation for cracks growing in the vicinity of a…
Residual stress is ubiquitous and indispensable in most biological and artificial materials, where it sustains and optimizes many biological and functional mechanisms. The theory of volume growth, starting from a stress-free initial state,…
Shape memory materials have gained considerable attention thanks to their ability to change physical properties when subjected to external stimuli such as temperature, pH, humidity, electromagnetic fields, etc. These materials are…
Dendrites are one of the most widely observed patterns in nature and occur across a wide spectrum of physical phenomena. In solidification and growth patterns in metals and crystals, the multi-level branching structures of dendrites pose a…
Growth-elasticity is a powerful model framework for understanding complex shape development in soft biological tissues. At each instant, by mapping how continuum building blocks have grown geometrically and how they respond elastically to…
We derive a course grained, continuum model of the 2D vertex model, applicable for different underlying geometries, and allowing for analytical analysis of an otherwise numerical model. Using a geometric approach and out--of--equilibrium…
We propose a mathematical model that combines elastic, viscous and porous effects with growth or shrinkage due to microstructural changes. This phenomenon is important in tissue or tumor growth, as well as in dermal contraction. Although…
We formulate a cut finite element method for linear elasticity based on higher order elements on a fixed background mesh. Key to the method is a stabilization term which provides control of the jumps in the derivatives of the finite element…
Metastases increase the risk of fracture when affecting the femur. Consequently, clinicians need to know if the patients femur can withstand the stress of daily activities. The current tools used in clinics are not sufficiently precise. A…
Non-particulate continuum descriptions allow for computationally efficient modeling of suspension flows at scales that are inaccessible to more detailed particulate approaches. It is well known that the presence of particles influences the…
In-stent restenosis (ISR) after percutaneous coronary intervention is a multi-factorial process. Specific morphological lesion characteristics were observed to contribute to the occurrence of ISR. Local mechanical factors, such as stresses…
Aneurysms are localized bulges of arteries, and they can rupture with fatal consequences. Complex mechanobiological factors preclude in vivo testing to assess the rupture risk of an aneurysm, and size based criteria are often used in…
Deformation modeling of cardiac muscle is an important issue in the field of cardiac analysis. For this reason, many approaches have been developed to best estimate the cardiac muscle deformation, and to obtain a practical model to use in…
A novel general purpose Finite Element framework is presented to study small-scale metal plasticity. A distinct feature of the adopted distortion gradient plasticity formulation, with respect to strain gradient plasticity theories, is the…
Angiogenesis is the formation of new blood vessels from pre-existing ones in response to chemical signals secreted by, for example, a wound or a tumour. In this paper, we propose a mesoscopic lattice-based model of angiogenesis, in which…
Angiogenesis, the development of new vasculature, is a critical process in the growth of new tumors. Driven by a goal to understand this aspect of cancer proliferation, I develop a discrete computationally optimized mathematical model of…
Bioprinting is an enabling biofabrication technique to create heterogeneous tissue constructs according to patient-specific geometries and compositions. Optimization of bioinks as per requirements for specific tissue applications is a…