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Microfluidics-based biochips are soon expected to revolutionize clinical diagnosis, DNA sequencing, and other laboratory procedures involving molecular biology. Most microfluidic biochips are based on the principle of continuous fluid flow…

硬件体系结构 · 计算机科学 2011-11-09 Fei Su , Krishnendu Chakrabarty

The mathematical modelling of biological systems has historically followed one of two approaches: comprehensive and minimal. In comprehensive models, the involved biological pathways are modelled independently, then brought together as an…

动力系统 · 数学 2021-11-16 Eric Ng , Jaycee Morgan Kaufman , Lennaert van Veen , Yan Fossat

We present a method and model for the direct and continuous separation of red and white blood cells in plasma. The method is implemented at the microscale using a microfluidic system that consists of an array of integrated soft-magnetic…

生物物理 · 物理学 2007-05-23 E. P. Furlani

The analysis of nano-and microparticle suspensions with micro systems affords improved space-time yields, selectivity, reaction residence times and conversions capabilities. These capabilities are of primary importance in various fields of…

仪器与探测器 · 物理学 2022-01-24 F. Onofri , Isaac Rodríguez-Ruiz , Fabrice Lamadie , Fabrice Onofri

Induction time, a measure of how long one will wait for nucleation to occur, is an important parameter in quantifying nucleation kinetics and its underlying mechanisms. Due to the stochastic nature of nucleation, efficient methods for…

An electrohydrodynamic numerical model is used to explore the electrospray emission behavior of both moderate and high electrical conductivity liquids under electrospray conditions. The Volume-of-Fluid method, incorporating a…

流体动力学 · 物理学 2022-11-30 Henry Huh , Richard E. Wirz

Diffuse correlation spectroscopy (DCS) analyzes the autocorrelation function of photons scattered by red blood cells, enabling non-invasive, continuous measurement of deep tissue blood flow at the bedside. Multi-layer DCS models (two- and…

Inferring physical fields from sparse observations while strictly satisfying partial differential equations (PDEs) is a fundamental challenge in computational physics. Recently, deep generative models offer powerful data-driven priors for…

机器学习 · 计算机科学 2026-01-29 Zichao Yu , Ming Li , Wenyi Zhang , Difan Zou , Weiguo Gao

Glucometers present an important self-monitoring tool for diabetes patients and therefore must exhibit high accu- racy as well as good usability features. Based on an invasive, photometric measurement principle that drastically reduces the…

应用统计 · 统计学 2016-02-11 Nevine Demitri , Abdelhak M. Zoubir

A mathematical model for fluid transport in peritoneal dialysis is constructed. The model is based on a three-component nonlinear system of two-dimensional partial differential equations for fluid, glucose and albumin transport with the…

偏微分方程分析 · 数学 2011-10-07 Roman Cherniha , Jacek Waniewski

We propose a portable cartridge based lab-on-a-chip platform. The main sensing mechanism uses high frequency acoustic waves. Feasibility of two different transducers has been investigated for biological measurements. We used zincoxide (ZnO)…

医学物理 · 物理学 2017-10-17 Seyedfakhreddin Nabavi

The conventional method of glucose measurement such as pricking blood from the body is prevalent which brings pain and trauma. Invasive methods of measurement sometimes raise the risk of blood infection to the patient. Sometimes, some of…

医学物理 · 物理学 2023-08-24 Prateek Jain , Amit Joshi , Saraju Mohanty

We present an ultra-efficient post-training method for shortcutting large-scale pre-trained flow matching diffusion models into efficient few-step samplers, enabled by novel velocity field self-distillation. While shortcutting in flow…

计算机视觉与模式识别 · 计算机科学 2025-10-22 Xu Cai , Yang Wu , Qianli Chen , Haoran Wu , Lichuan Xiang , Hongkai Wen

By reducing resolution, coarse-grained models greatly accelerate molecular simulations, unlocking access to long-timescale phenomena, though at the expense of microscopic information. Recovering this fine-grained detail is essential for…

化学物理 · 物理学 2026-03-27 Sander Hummerich , Tristan Bereau , Ullrich Köthe

Thanks to novel, powerful brain activity recording techniques, we can create data-driven models from thousands of recording channels and large portions of the cortex, which can improve our understanding of brain-states neuromodulation and…

We present experimental evidence of multiple blood flow configurations in a relatively simple microfluidic network under constant inlet conditions. We provide evidence of multistability and unsteady dynamics and find good agreement with a…

流体动力学 · 物理学 2024-10-08 Mathieu Alonzo , Nathaniel J. Karst , Thomas Podgorski , John B. Geddes , Gwennou Coupier

Elevated stress negatively impacts health, increasing the risk of cardiovascular diseases, weak immunity, anxiety, and cognitive decline. Current lab-based methods lack real-time stress measurement, while saliva diagnostics offers a…

医学物理 · 物理学 2024-10-11 Atul Sharma , Nafize Ishtiaque Hossain , Ayanna Thomas , Sameer Sonkusale

Dye experimentation is a widely used method in experimental fluid mechanics for flow analysis or for the study of the transport of particles within a fluid. This technique is particularly useful in biomedical diagnostic applications ranging…

流体动力学 · 物理学 2023-09-25 Faisal Amlani , Heng Wei , Niema M. Pahlevan

Timely diagnostics of microcirculatory system abnormalities which are the most severe diabetic complications, is a significant problem of modern health care. Functional abnormalities manifest themselves earlier than the structural one and…

组织与器官 · 定量生物学 2024-11-27 Irina Mizeva , Elena Zharkikh , Victor Dremin , Evgeny Zherebtsov , Irina Makovik , Elena Potapova , Andrey Dunaev

An algorithm based on PLS regression has been developed and optimized for measuring blood glucose level using the infra-red transmission spectrum of blood samples. A set of blood samples were tagged with their glucose concentration using an…

定量方法 · 定量生物学 2018-04-11 Afarin Aghassizadeh , Mohammad Reza Nematollahi , Iman Mirzaie , Mehdi Fardmanesh