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In genome-wide epigenetic studies, exposures (e.g., Single Nucleotide Polymorphisms) affect outcomes (e.g., gene expression) through intermediate variables such as DNA methylation. Mediation analysis offers a way to study these intermediate…

统计方法学 · 统计学 2025-12-08 Asmita Roy , Xianyang Zhang

We introduce a new dataset, MELINDA, for Multimodal biomEdicaL experImeNt methoD clAssification. The dataset is collected in a fully automated distant supervision manner, where the labels are obtained from an existing curated database, and…

计算与语言 · 计算机科学 2020-12-18 Te-Lin Wu , Shikhar Singh , Sayan Paul , Gully Burns , Nanyun Peng

Model based diagnosis finds a growing range of practical applications, and significant performance-wise improvements have been achieved in recent years. Some of these improvements result from formulating the problem with maximum…

计算机科学中的逻辑 · 计算机科学 2017-07-10 Alexey Ignatiev , Antonio Morgado , Joao Marques-Silva

Owing to the recent advancements in wearable devices for health care, the importance of BP estimation without cuffs increases. Cuff technologies are inappropriate for continuous BP measurement due to their inconvenient usage, invasive…

信号处理 · 电气工程与系统科学 2026-05-05 Vaibhav Gollapalli , Aniruth Ananthanarayanan

Recent integration of Natural Language Processing (NLP) and multimodal models has advanced the field of sports analytics. This survey presents a comprehensive review of the datasets and applications driving these innovations post-2020. We…

计算与语言 · 计算机科学 2024-06-19 Haotian Xia , Zhengbang Yang , Yun Zhao , Yuqing Wang , Jingxi Li , Rhys Tracy , Zhuangdi Zhu , Yuan-fang Wang , Hanjie Chen , Weining Shen

Inference in models where the parameter is defined by moment inequalities is of interest in many areas of economics. This paper develops a new method for improving the performance of generalized moment selection (GMS) testing procedures in…

计量经济学 · 经济学 2020-08-26 Rami V. Tabri , Christopher D. Walker

Machine Learning (ML) has garnered considerable attention from researchers and practitioners as a new and adaptable tool for disease diagnosis. With the advancement of ML and the proliferation of papers and research in this field, a…

机器学习 · 计算机科学 2022-01-11 Md Manjurul Ahsan , Zahed Siddique

We propose two novel nonparametric two-sample kernel tests based on the Maximum Mean Discrepancy (MMD). First, for a fixed kernel, we construct an MMD test using either permutations or a wild bootstrap, two popular numerical procedures to…

High-dimensional datasets are frequently subject to contamination by outliers and heavy-tailed noise, which can severely bias standard regularized estimators like the Lasso. While Maximum Mean Discrepancy (MMD) has recently been introduced…

统计方法学 · 统计学 2026-02-25 Xiaoning Kang , Lulu Kang

This paper presents an approach to the evaluation and validation of mass spectrometry data for construction of an `early warning' diagnostic procedure. We describe implementation of a designed experiment and place emphasis on the consistent…

统计理论 · 数学 2007-06-13 Bart J. A. Mertens , M. E. de Noo , R. A. E. M. Tollenaar , A. M. Deelder

Major depressive disorder (MDD) impacts more than 300 million people worldwide, highlighting a significant public health issue. However, the uneven distribution of medical resources and the complexity of diagnostic methods have resulted in…

计算与语言 · 计算机科学 2025-05-02 Yuyang Sha , Hongxin Pan , Wei Xu , Weiyu Meng , Gang Luo , Xinyu Du , Xiaobing Zhai , Henry H. Y. Tong , Caijuan Shi , Kefeng Li

High-dimensional regression specification and analysis is a complex and active area of research in statistics, machine learning, and econometrics. This paper proposes a new approach, Boosting with Multiple Testing (BMT), which combines…

计量经济学 · 经济学 2026-02-24 George Kapetanios , Vasilis Sarafidis , Alexia Ventouri

We study the performance of machine learning binary classification techniques in terms of error probabilities. The statistical test is based on the Data-Driven Decision Function (D3F), learned in the training phase, i.e., what is…

机器学习 · 计算机科学 2023-01-19 Paolo Braca , Leonardo M. Millefiori , Augusto Aubry , Antonio De Maio , Peter Willett

Concept Bottleneck Models (CBMs) assume that training examples (e.g., x-ray images) are annotated with high-level concepts (e.g., types of abnormalities), and perform classification by first predicting the concepts, followed by predicting…

计算与语言 · 计算机科学 2023-12-19 Danis Alukaev , Semen Kiselev , Ilya Pershin , Bulat Ibragimov , Vladimir Ivanov , Alexey Kornaev , Ivan Titov

We present a selective sampling method designed to accelerate the training of deep neural networks. To this end, we introduce a novel measurement, the minimal margin score (MMS), which measures the minimal amount of displacement an input…

机器学习 · 计算机科学 2019-11-19 Berry Weinstein , Shai Fine , Yacov Hel-Or

For randomized controlled trials to be conclusive, it is important to set the target sample size accurately at the design stage. Comparing two normal populations, the sample size calculation requires specification of the variance other than…

统计方法学 · 统计学 2026-02-04 Hirotada Maeda , Satoshi Hattori , Tim Friede

Dynamic Causal Modeling (DCM) is a Bayesian framework for inferring on hidden (latent) neuronal states, based on measurements of brain activity. Since its introduction in 2003 for functional magnetic resonance imaging data, DCM has been…

定量方法 · 定量生物学 2021-04-08 Inês Pereira , Stefan Frässle , Jakob Heinzle , Dario Schöbi , Cao Tri Do , Moritz Gruber , Klaas E. Stephan

Gradient Boosting (GB) is a popular methodology used to solve prediction problems by minimizing a differentiable loss function, $L$. GB performs very well on tabular machine learning (ML) problems; however, as a pure ML solver it lacks the…

机器学习 · 计算机科学 2022-11-08 Michael T. Horrell

Widely used methods for analyzing missing data can be biased in small samples. To understand these biases, we evaluate in detail the situation where a small univariate normal sample, with values missing at random, is analyzed using either…

统计理论 · 数学 2017-03-27 Paul T. von Hippel

This paper investigates the MM dynamics approach proposed by Han et al. (2022) for multi-modal fusion in biomedical classification tasks. The MM dynamics algorithm integrates feature-level and modality-level informativeness to dynamically…

机器学习 · 计算机科学 2024-11-04 Laura Wenderoth