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Graph neural networks (GNNs) have emerged as one of the most effective ML techniques for drug effect prediction from drug molecular graphs. Despite having immense potential, GNN models lack performance when using datasets that contain…

机器学习 · 计算机科学 2024-10-15 Avishek Bose , Guojing Cong

Understanding the factors that trigger or prevent undesirable health outcomes across patient subpopulations is essential for designing targeted interventions. While randomized controlled trials and expert-led patient interviews are standard…

人工智能 · 计算机科学 2026-05-28 Shishir Adhikari , Guido Muscioni , Mark Shapiro , Plamen Petrov , Elena Zheleva

Algorithmic bias often arises as a result of differential subgroup validity, in which predictive relationships vary across groups. For example, in toxic language detection, comments targeting different demographic groups can vary markedly…

机器学习 · 计算机科学 2023-03-08 Soumyajit Gupta , Sooyong Lee , Maria De-Arteaga , Matthew Lease

Multilevel regression and poststratification (MRP) is a flexible modeling technique that has been used in a broad range of small-area estimation problems. Traditionally, MRP studies have been focused on non-causal settings, where estimating…

统计方法学 · 统计学 2022-01-24 Yuxiang Gao , Lauren Kennedy , Daniel Simpson

Treatment effect heterogeneity occurs when individual characteristics influence the effect of a treatment. We propose a novel approach that combines prognostic score matching and conditional inference trees to characterize effect…

The limited availability of annotations in small molecule datasets presents a challenge to machine learning models. To address this, one common strategy is to collaborate with additional auxiliary datasets. However, having more data does…

生物大分子 · 定量生物学 2023-11-10 Tinglin Huang , Ziniu Hu , Rex Ying

Multimodal learning integrates diverse modalities but suffers from modality imbalance, where dominant modalities suppress weaker ones due to inconsistent convergence rates. Existing methods predominantly rely on static modulation or…

机器学习 · 计算机科学 2026-02-11 Zhaocheng Liu , Zhiwen Yu , Xiaoqing Liu

Subgroup-specific meta-analysis synthesizes treatment effects for patient subgroups across randomized trials. Methods include joint or separate modeling of subgroup effects and treatment-by-subgroup interactions, but inconsistencies arise…

统计方法学 · 统计学 2025-08-22 Renato Panaro , Christian Röver , Tim Friede

This paper studies full-body 3D human motion recovery from head-mounted device signals. Existing diffusion-based methods often rely on global distribution matching, leading to local joint reconstruction errors. We propose MotionGRPO, a…

计算机视觉与模式识别 · 计算机科学 2026-05-13 Nanjie Yao , Junlong Ren , Wenhao Shen , Hao Wang

Learning effective joint embedding for cross-modal data has always been a focus in the field of multimodal machine learning. We argue that during multimodal fusion, the generated multimodal embedding may be redundant, and the discriminative…

机器学习 · 计算机科学 2022-12-06 Sijie Mai , Ying Zeng , Haifeng Hu

Understanding whether and how treatment effects vary across subgroups is crucial to inform clinical practice and recommendations. Accordingly, the assessment of heterogeneous treatment effects (HTE) based on pre-specified potential effect…

统计方法学 · 统计学 2023-12-04 Bryan S. Blette , Scott D. Halpern , Fan Li , Michael O. Harhay

RGB-Infrared person re-identification (RGB-IR ReID) aims to associate people across disjoint RGB and IR camera views. Currently, state-of-the-art performance of RGB-IR ReID is not as impressive as that of conventional ReID. Much of that is…

计算机视觉与模式识别 · 计算机科学 2022-04-27 Lin Wan , Qianyan Jing , Zongyuan Sun , Chuang Zhang , Zhihang Li , Yehansen Chen

Randomized controlled trials estimate average treatment effects, but treatment response heterogeneity motivates personalized approaches. A critical question is whether statistically detectable heterogeneity translates into improved…

机器学习 · 计算机科学 2026-02-10 Cristian Minoccheri , Sophia Tesic , Kayvan Najarian , Ryan Stidham

In scientific domains -- from biology to the social sciences -- many questions boil down to \textit{What effect will we observe if we intervene on a particular variable?} If the causal relationships (e.g.~a causal graph) are known, it is…

Covariate shift and outcome model heterogeneity are two prominent challenges in leveraging external sources to improve risk modeling for underrepresented cohorts in paucity of accurate labels. We consider the transfer learning problem…

统计方法学 · 统计学 2024-10-10 Doudou Zhou , Mengyan Li , Tianxi Cai , Molei Liu

Cluster-randomized trials (CRTs) are widely used to evaluate interventions delivered at the clinic, practice, or community level. Although standard analyses typically target average treatment effects, such summaries mask potentially…

统计方法学 · 统计学 2026-04-16 Changjun Li , Xi Fang , Michael O. Harhay , Andrew B. Forbes , F. Perry Wilson , Guangyu Tong , Fan Li

Estimating heterogeneous treatment effects is an important problem across many domains. In order to accurately estimate such treatment effects, one typically relies on data from observational studies or randomized experiments. Currently,…

In randomized trials, repeated measures of the outcome are routinely collected. The mixed model for repeated measures (MMRM) leverages the information from these repeated outcome measures, and is often used for the primary analysis to…

统计方法学 · 统计学 2023-07-20 Bingkai Wang , Yu Du

Effect modification means the size of a treatment effect varies with an observed covariate. Generally speaking, a larger treatment effect with more stable error terms is less sensitive to bias. Thus, we might be able to conclude that a…

统计方法学 · 统计学 2026-05-19 Yijun Fan , Dylan S. Small

Survival prediction is a critical task in pathology. In clinical practice, pathologists often examine multiple cases, leveraging a broader spectrum of cancer phenotypes to enhance pathological assessment. Despite significant advancements in…

计算机视觉与模式识别 · 计算机科学 2024-11-26 Xinyang Li , Yi Zhang , Yi Xie , Jianfei Yang , Xi Wang , Hao Chen , Haixian Zhang