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Providing architectural support is crucial for newly arising applications to achieve high performance and high system efficiency. Currently there is a trend in designing accelerators for special applications, while arguably a debate is…

分布式、并行与集群计算 · 计算机科学 2019-11-04 Yuhang Liu , Luming Wang , Xiang Li , Yang Wang , Mingyu Chen , Yungang Bao

The rise of data-intensive applications exposed the limitations of conventional processor-centric von-Neumann architectures that struggle to meet the off-chip memory bandwidth demand. Therefore, recent innovations in computer architecture…

硬件体系结构 · 计算机科学 2024-05-28 Asif Ali Khan , Hamid Farzaneh , Karl F. A. Friebel , Clément Fournier , Lorenzo Chelini , Jeronimo Castrillon

Kernel matrices (e.g. Gram or similarity matrices) are essential for many state-of-the-art approaches to classification, clustering, and dimensionality reduction. For large datasets, the cost of forming and factoring such kernel matrices…

Reducing the cost of sequencing genomes provided by next-generation sequencing technologies has greatly increased the number of genomic projects. As a result, there is a growing need for better assembly and assembly validation methods. One…

基因组学 · 定量生物学 2022-10-17 Przemysław Stawczyk , Robert Nowak

Next-generation sequencing (NGS) technologies have enabled affordable sequencing of billions of short DNA fragments at high throughput, paving the way for population-scale genomics. Genomics data analytics at this scale requires overcoming…

数据库 · 计算机科学 2019-10-11 Darryl Ho , Jialin Ding , Sanchit Misra , Nesime Tatbul , Vikram Nathan , Vasimuddin Md , Tim Kraska

The continually increasing volume of DNA sequence data has resulted in a growing demand for fast implementations of core algorithms. Computation of pairwise alignments between candidate haplotypes and sequencing reads using Pair-HMMs is a…

分布式、并行与集群计算 · 计算机科学 2026-01-27 Bertil Schmidt , Felix Kallenborn , Alexander Wichmann , Alejandro Chacon , Christian Hundt

In recent years, the rapidly increasing number of reads produced by next-generation sequencing (NGS) technologies has driven the demand for efficient implementations of sequence alignments in bioinformatics. However, current…

分布式、并行与集群计算 · 计算机科学 2022-05-17 André Müller , Bertil Schmidt , Richard Membarth , Roland Leißa , Sebastian Hack

Deep Learning Recommendation Model(DLRM)s utilize the embedding layer to represent various categorical features. Traditional DLRMs adopt unified embedding size for all features, leading to suboptimal performance and redundant parameters.…

信息检索 · 计算机科学 2024-11-13 He Wei , Yuekui Yang , Yang Zhang , Haiyang Wu , Meixi Liu , Shaoping Ma

Generative Large Language Models (LLMs) have demonstrated remarkable results for a wide range of tasks. However, deploying these models for inference has been a significant challenge due to their unprecedented resource requirements. This…

计算与语言 · 计算机科学 2024-06-06 Sehoon Kim , Coleman Hooper , Amir Gholami , Zhen Dong , Xiuyu Li , Sheng Shen , Michael W. Mahoney , Kurt Keutzer

Long-context DNA models are limited by token-mixing cost and by how compression allocates representational budget across the genome. Existing approaches operate close to base-pair resolution, apply fixed downsampling, or learn…

基因组学 · 定量生物学 2026-05-13 Jianan Zhao , Xixian Liu , Zhihao Zhan , Xinyu Yuan , Hongyu Guo , Jian Tang

The surge in availability of genomic data holds promise for enabling determination of genetic causes of observed individual traits, with applications to problems such as discovery of the genetic roots of phenotypes, be they molecular…

分布式、并行与集群计算 · 计算机科学 2018-04-23 Wayne Joubert , James Nance , Deborah Weighill , Daniel Jacobson

Approximate Nearest Neighbor Search (ANNS) is a cornerstone algorithm for information retrieval, recommendation systems, and machine learning applications. While x86-based architectures have historically dominated this domain, the…

A novel generative site-specific beamforming (GenSSBF) approach, termed fast beam-brainstorm (F-BBS), is proposed to address the practical bottlenecks of slow beam generation and fixed channel probing lengths in existing GenSSBF. To…

信号处理 · 电气工程与系统科学 2026-03-19 Zihao Zhou , Zhaolin Wang , Yuanwei Liu

Spatial transcriptomics (ST) technologies enable gene expression profiling with spatial resolution, offering unprecedented insights into tissue organization and disease heterogeneity. However, current analysis methods often struggle with…

Genome assembly from the high-throughput sequencing (HTS) reads is a fundamental yet challenging computational problem. An intrinsic challenge is the uncertainty caused by the widespread repetitive elements. Here we get around the…

基因组学 · 定量生物学 2016-09-13 Anqi Wang , Zheng Li , Zhanyu Wang , Lei M. Li

Pseudo-heterodyne scattering-type scanning near-field optical microscopy (sSNOM) is applied in the mid-infrared region to detect the chemical composition of biomolecules on the nanoscale. However, the application of sSNOM in molecular…

仪器与探测器 · 物理学 2025-08-06 Yusuke Sakiyama , Emanuel Pfitzner , Santiago H. Andany , Georg E. Fantner , Joachim Heberle

Subgraph matching has garnered increasing attention for its diverse real-world applications. Given the dynamic nature of real-world graphs, addressing evolving scenarios without incurring prohibitive overheads has been a focus of research.…

分布式、并行与集群计算 · 计算机科学 2024-01-31 Linshan Qiu , Lu Chen , Hailiang Jie , Xiangyu Ke , Yunjun Gao , Yang Liu , Zetao Zhang

To address the challenge of increasing network size, researchers have developed sparse models through network pruning. However, maintaining model accuracy while achieving significant speedups on general computing devices remains an open…

人工智能 · 计算机科学 2023-10-31 Haitao Xu , Songwei Liu , Yuyang Xu , Shuai Wang , Jiashi Li , Chenqian Yan , Liangqiang Li , Lean Fu , Xin Pan , Fangmin Chen

While Large Language Models (LLMs) have achieved remarkable success in various fields, the efficiency of training and inference remains a major challenge. To address this issue, we propose SUBLLM, short for Subsampling-Upsampling-Bypass…

计算与语言 · 计算机科学 2024-08-26 Quandong Wang , Yuxuan Yuan , Xiaoyu Yang , Ruike Zhang , Kang Zhao , Wei Liu , Jian Luan , Daniel Povey , Bin Wang

Self-Attention Mechanism (SAM) is good at capturing the internal connections of features and greatly improves the performance of machine learning models, espeacially requiring efficient characterization and feature extraction of…

量子物理 · 物理学 2023-08-08 Jinjing Shi , Ren-Xin Zhao , Wenxuan Wang , Shichao Zhang , Xuelong Li