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We present a weakly supervised deep learning method to perform instance segmentation of cells present in microscopy images. Annotation of biomedical images in the lab can be scarce, incomplete, and inaccurate. This is of concern when…

计算机视觉与模式识别 · 计算机科学 2019-08-28 Fidel A. Guerrero-Peña , Pedro D. Marrero Fernandez , Tsang Ing Ren , Alexandre Cunha

Cell shape analysis is important in biomedical research. Deep learning methods may perform to segment individual cells if they use sufficient training data that the boundary of each cell is annotated. However, it is very time-consuming for…

图像与视频处理 · 电气工程与系统科学 2020-02-26 Kazuya Nishimura , Dai Fei Elmer Ker , Ryoma Bise

Increasing data set sizes of 3D microscopy imaging experiments demand for an automation of segmentation processes to be able to extract meaningful biomedical information. Due to the shortage of annotated 3D image data that can be used for…

图像与视频处理 · 电气工程与系统科学 2022-02-02 Dennis Eschweiler , Richard S. Smith , Johannes Stegmaier

Weakly supervised nuclei segmentation is a critical problem for pathological image analysis and greatly benefits the community due to the significant reduction of labeling cost. Adopting point annotations, previous methods mostly rely on…

图像与视频处理 · 电气工程与系统科学 2022-02-14 Weizhen Liu , Qian He , Xuming He

Cell instance segmentation is a new and challenging task aiming at joint detection and segmentation of every cell in an image. Recently, many instance segmentation methods have applied in this task. Despite their great success, there still…

计算机视觉与模式识别 · 计算机科学 2022-08-18 Menghao Li , Wenquan Feng , Shuchang Lyu , Lijiang Chen , Qi Zhao

Developing clinically useful cell-level analysis tools in digital pathology remains challenging due to limitations in dataset granularity, inconsistent annotations, high computational demands, and difficulties integrating new technologies…

计算机视觉与模式识别 · 计算机科学 2025-12-02 Nikita Shvetsov , Thomas K. Kilvaer , Masoud Tafavvoghi , Anders Sildnes , Kajsa Møllersen , Lill-Tove Rasmussen Busund , Lars Ailo Bongo

Recent approaches for weakly supervised instance segmentations depend on two components: (i) a pseudo label generation model that provides instances which are consistent with a given annotation; and (ii) an instance segmentation model,…

计算机视觉与模式识别 · 计算机科学 2020-07-21 Aditya Arun , C. V. Jawahar , M. Pawan Kumar

We address a weakly-supervised low-shot instance segmentation, an annotation-efficient training method to deal with novel classes effectively. Since it is an under-explored problem, we first investigate the difficulty of the problem and…

计算机视觉与模式识别 · 计算机科学 2023-08-01 Moon Ye-Bin , Dongmin Choi , Yongjin Kwon , Junsik Kim , Tae-Hyun Oh

Estimation and inference with modern longitudinal data from wearable devices, which consist of biological signals at high-frequency time points, is burdened by massive computational costs. We propose a distributed estimation and inference…

统计方法学 · 统计学 2023-09-13 Cole Manschot , Emily C. Hector

Manually annotating nuclei from the gigapixel Hematoxylin and Eosin (H&E)-stained Whole Slide Images (WSIs) is a laborious and costly task, meaning automated algorithms for cell nuclei instance segmentation and classification could…

计算机视觉与模式识别 · 计算机科学 2024-07-29 João D. Nunes , Diana Montezuma , Domingos Oliveira , Tania Pereira , Jaime S. Cardoso

Nuclei segmentation is a fundamental task in histopathology image analysis. Typically, such segmentation tasks require significant effort to manually generate accurate pixel-wise annotations for fully supervised training. To alleviate such…

计算机视觉与模式识别 · 计算机科学 2020-07-13 Hui Qu , Pengxiang Wu , Qiaoying Huang , Jingru Yi , Zhennan Yan , Kang Li , Gregory M. Riedlinger , Subhajyoti De , Shaoting Zhang , Dimitris N. Metaxas

Copy-Paste has proven to be a very effective data augmentation for instance segmentation which can improve the generalization of the model. We used a task-specific Copy-Paste data augmentation method to achieve good performance on the…

计算机视觉与模式识别 · 计算机科学 2021-10-04 Jahongir Yunusov , Shohruh Rakhmatov , Abdulaziz Namozov , Abdulaziz Gaybulayev , Tae-Hyong Kim

Nuclei instance segmentation in hematoxylin and eosin (H&E)-stained images plays an important role in automated histological image analysis, with various applications in downstream tasks. While several machine learning and deep learning…

计算机视觉与模式识别 · 计算机科学 2026-01-29 Nima Torbati , Anastasia Meshcheryakova , Ramona Woitek , Sepideh Hatamikia , Diana Mechtcheriakova , Amirreza Mahbod

Cell and nucleus segmentation are fundamental tasks for quantitative bioimage analysis. Despite progress in recent years, biologists and other domain experts still require novel algorithms to handle increasingly large and complex real-world…

计算机视觉与模式识别 · 计算机科学 2024-08-29 Thibaut Goldsborough , Ben Philps , Alan O'Callaghan , Fiona Inglis , Leo Leplat , Andrew Filby , Hakan Bilen , Peter Bankhead

Automated detection of grain boundaries (GBs) in electron microscope images of polycrystalline materials could help accelerate the nanoscale characterization of myriad engineering materials and novel materials under scientific research.…

材料科学 · 物理学 2025-11-06 Doruk Aksoy , Huolin L. Xin , Timothy J. Rupert , William J. Bowman

We introduce CellSegmenter, a structured deep generative model and an amortized inference framework for unsupervised representation learning and instance segmentation tasks. The proposed inference algorithm is convolutional and…

计算机视觉与模式识别 · 计算机科学 2020-11-26 Luca D'Alessio , Mehrtash Babadi

We propose a method to incorporate the intensity information of a target lesion on CT scans in training segmentation and detection networks. We first build an intensity-based lesion probability (ILP) function from an intensity histogram of…

图像与视频处理 · 电气工程与系统科学 2023-07-13 Seung Yeon Shin , Thomas C. Shen , Ronald M. Summers

Small sample instance segmentation is a very challenging task, and many existing methods follow the training strategy of meta-learning which pre-train models on support set and fine-tune on query set. The pre-training phase, which is highly…

计算机视觉与模式识别 · 计算机科学 2024-10-22 Ruting Chi , Zhiyi Huang , Yuexing Han

As predictive algorithms grow in popularity, using the same dataset to both train and test a new model has become routine across research, policy, and industry. Sample-splitting attains valid inference on model properties by using separate…

计量经济学 · 经济学 2025-11-27 Bruno Fava

Nuclei instance segmentation on histopathology images is of great clinical value for disease analysis. Generally, fully-supervised algorithms for this task require pixel-wise manual annotations, which is especially time-consuming and…

计算机视觉与模式识别 · 计算机科学 2023-06-06 Yang Zhou , Yongjian Wu , Zihua Wang , Bingzheng Wei , Maode Lai , Jianzhong Shou , Yubo Fan , Yan Xu
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