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Causal inference and model interpretability research are gaining increasing attention, especially in the domains of healthcare and bioinformatics. Despite recent successes in this field, decorrelating features under nonlinear environments…

机器学习 · 计算机科学 2022-09-30 Junda Wang , Weijian Li , Han Wang , Hanjia Lyu , Caroline Thirukumaran , Addisu Mesfin , Jiebo Luo

The wide implementation of electronic health record (EHR) systems facilitates the collection of large-scale health data from real clinical settings. Despite the significant increase in adoption of EHR systems, this data remains largely…

定量方法 · 定量生物学 2018-10-26 Jinghe Zhang , Kamran Kowsari , James H. Harrison , Jennifer M. Lobo , Laura E. Barnes

In this paper, we address the "black-box" problem in predictive process analytics by building interpretable models that are capable to inform both what and why is a prediction. Predictive process analytics is a newly emerged discipline…

机器学习 · 计算机科学 2022-04-26 Bemali Wickramanayake , Zhipeng He , Chun Ouyang , Catarina Moreira , Yue Xu , Renuka Sindhgatta

There is a growing concern about typically opaque decision-making with high-performance machine learning algorithms. Providing an explanation of the reasoning process in domain-specific terms can be crucial for adoption in risk-sensitive…

计算机视觉与模式识别 · 计算机科学 2022-11-28 Aditya Chattopadhyay , Stewart Slocum , Benjamin D. Haeffele , Rene Vidal , Donald Geman

Clustering is a fundamental learning task widely used as a first step in data analysis. For example, biologists use cluster assignments to analyze genome sequences, medical records, or images. Since downstream analysis is typically…

机器学习 · 计算机科学 2024-06-11 Jonathan Svirsky , Ofir Lindenbaum

Interpretability of machine learning models is critical for data-driven precision medicine efforts. However, highly predictive models are generally complex and are difficult to interpret. Here using Model-Agnostic Explanations algorithm, we…

定量方法 · 定量生物学 2016-10-31 Gajendra Jung Katuwal , Robert Chen

Continual learning aims to update models under distribution shift without forgetting, yet many high-stakes deployments, such as healthcare, also require interpretability. In practice, models that adapt well (e.g., deep networks) are often…

机器学习 · 计算机科学 2026-04-21 Dongkyu Cho , Xiyue Li , Samrachana Adhikari , Rumi Chunara

This paper describes methods for comparative evaluation of the interpretability of models of high dimensional time series data inferred by unsupervised machine learning algorithms. The time series data used in this investigation were logs…

人工智能 · 计算机科学 2020-05-05 Nicholas Hoernle , Kobi Gal , Barbara Grosz , Leilah Lyons , Ada Ren , Andee Rubin

We take inspiration from the study of human explanation to inform the design and evaluation of interpretability methods in machine learning. First, we survey the literature on human explanation in philosophy, cognitive science, and the…

人工智能 · 计算机科学 2021-09-21 David Alvarez-Melis , Harmanpreet Kaur , Hal Daumé , Hanna Wallach , Jennifer Wortman Vaughan

Interpretable representations are the backbone of many explainers that target black-box predictive systems based on artificial intelligence and machine learning algorithms. They translate the low-level data representation necessary for good…

机器学习 · 计算机科学 2024-04-29 Kacper Sokol , Peter Flach

We argue that existing definitions of interpretability are not actionable in that they fail to inform users about general, sound, and robust interpretable model design. This makes current interpretability research fundamentally ill-posed.…

机器学习 · 计算机科学 2025-08-04 Pietro Barbiero , Mateo Espinosa Zarlenga , Alberto Termine , Mateja Jamnik , Giuseppe Marra

The ubiquity of machine learning based predictive models in modern society naturally leads people to ask how trustworthy those models are? In predictive modeling, it is quite common to induce a trade-off between accuracy and…

机器学习 · 计算机科学 2019-04-05 John Mitros , Brian Mac Namee

Deep learning-based AI models have been extensively applied in genomics, achieving remarkable success across diverse applications. As these models gain prominence, there exists an urgent need for interpretability methods to establish…

基因组学 · 定量生物学 2025-05-16 Chenyu Wang , Chaoying Zuo , Zihan Su , Yuhang Xing , Lu Li , Maojun Wang , Zeyu Zhang

Current machine learning models are evaluated through behavioral snapshots, with benchmark accuracies, win rates and outcome-based metrics. Model explanations and evaluations, however, are fundamentally intertwined: understanding why a…

计算机与社会 · 计算机科学 2026-05-08 Isabelle Lee , Emmy Liu , Cathy Jiao , Brihi Joshi , Dani Yogatama , Fazl Barez , Michael Saxon

Diagnosing rare diseases presents a common challenge in clinical practice, necessitating the expertise of specialists for accurate identification. The advent of machine learning offers a promising solution, while the development of such…

With the growing use of new technologies, healthcare is nowadays undergoing significant changes. Information-based medicine has to exploit medical decision-support systems and requires the analysis of various, heterogeneous data, such as…

数据库 · 计算机科学 2008-09-17 Jérôme Darmont , Emerson Olivier

Interpretability is often pointed out as a key requirement for trustworthy machine learning. However, learning and releasing models that are inherently interpretable leaks information regarding the underlying training data. As such…

人工智能 · 计算机科学 2024-04-04 Julien Ferry , Ulrich Aïvodji , Sébastien Gambs , Marie-José Huguet , Mohamed Siala

The field of machine learning has seen tremendous progress in recent years, with deep learning models delivering exceptional performance across a range of tasks. However, these models often come at the cost of interpretability, as they…

机器学习 · 计算机科学 2024-01-08 Shun Liu

Interpretability for machine learning models in medical imaging (MLMI) is an important direction of research. However, there is a general sense of murkiness in what interpretability means. Why does the need for interpretability in MLMI…

Language models based on the Transformer architecture achieve excellent results in many language-related tasks, such as text classification or sentiment analysis. However, despite the architecture of these models being well-defined, little…