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Raman spectroscopy can be used to identify molecules such as DNA by the characteristic scattering of light from a laser. It is sensitive at very low concentrations and can accurately quantify the amount of a given molecule in a sample. The…

应用统计 · 统计学 2026-02-03 Matthew Moores , Kirsten Gracie , Jake Carson , Karen Faulds , Duncan Graham , Mark Girolami

Imaging specimens over large scales and with a sub-micron resolution is instrumental to biomedical research. Yet, the number of pixels to form such an image usually exceeds the number of pixels provided by conventional cameras. While most…

仪器与探测器 · 物理学 2019-12-03 Gaelle Recher , Pierre Nassoy , Amaury Badon

We present multi-color imaging by stimulated Raman scattering (SRS) enabled by an ultrafast fiber-based light source with integrated amplitude modulation and frame-to-frame wavelength tuning. With a relative intensity noise level of -153.7…

Optical spectroscopy with broadband femtosecond laser pulses often involves simultaneous excitation of multiple molecular species with close resonance frequencies. Interpreting the collective optical response from molecular mixtures…

光学 · 物理学 2016-04-13 Martin Bitter , Valery Milner

In this work, we propose using camera arrays coupled with coherent illumination as an effective method of improving spatial resolution in long distance images by a factor of ten and beyond. Recent advances in ptychography have demonstrated…

计算机视觉与模式识别 · 计算机科学 2015-11-29 Jason Holloway , M. Salman Asif , Manoj Kumar Sharma , Nathan Matsuda , Roarke Horstmeyer , Oliver Cossairt , Ashok Veeraraghavan

Nonlinear spectroscopy employs a series of laser pulses to interrogate dynamics in large interacting many-body systems, and has become a highly successful method for experiments in chemical physics. Current quantum optical experiments…

量子物理 · 物理学 2016-10-19 Frank Schlawin , Manuel Gessner , Shaul Mukamel , Andreas Buchleitner

The broadband, coherent nature of narrow-linewidth fiber frequency combs is exploited to measure the full complex spectrum of a molecular gas through multi-heterodyne spectroscopy. We measure the absorption and phase shift experienced by…

光学 · 物理学 2009-11-13 Ian Coddington , William C. Swann , Nathan R. Newbury

Highest resolution laser spectroscopy has generally been limited to single trapped ion systems due to rapid decoherence which plagues neutral atom ensembles. Here, precision spectroscopy of ultracold neutral atoms confined in a trapping…

Broadband precision spectroscopy is indispensable for providing high fidelity molecular parameters for spectroscopic databases. We have recently shown that mechanical Fourier transform spectrometers based on optical frequency combs can…

We developed an optical-resolution photoacoustic microscope (OR-PAM) capable of changing focal plane with high-speed by using a tunable acoustic gradient (TAG) lens. In our system, a TAG lens is designed to continuously changing the focal…

光学 · 物理学 2020-09-09 Xianlin Song

We present an imaging technique that allows the recovery of the transparency profile of wavelength-scale objects with deep subwavelength resolution based on far-field intensity measurements. The approach, interscale mixing microscopy (IMM),…

光学 · 物理学 2017-03-21 Sandeep Inampudi , Nicholas Kuhta , Viktor A. Podolskiy

Spectral imaging is a fundamental diagnostic technique with widespread application. Conventional spectral imaging approaches have intrinsic limitations on spatial and spectral resolutions due to the physical components they rely on. To…

图像与视频处理 · 电气工程与系统科学 2021-06-07 Figen S. Oktem , Oğuzhan Fatih Kar , Can Deniz Bezek , Farzad Kamalabadi

We present a new scheme to create all-optical tunable and lossless waveguide using a controllable coherent Raman process in an atomic rubidium vapor in N-type configuration. We employ a Gaussian Raman field and a Laguerre-Gaussian control…

光学 · 物理学 2024-04-18 Sandeep Sharma

Due to their sub picosecond temporal resolution, coherent Raman spectroscopies have been proposed as a viable extension of Spontaneous Raman (SR) thermometry, to determine dynamics of mode specific vibrational energy content during out of…

An integrated microscope that combines different optical techniques for simultaneous imaging is demonstrated. The microscope enables spectral-domain optical coherence microscopy based on optical backscatter, and multi-photon microscopy for…

光学 · 物理学 2009-11-11 C. Vinegoni , T. Ralston , W. Tan , W. Luo , D. L. Marks , S. A. Boppart

We developed a novel technique for frequency measurement and synthesis, based on the operation of a femtosecond comb generator as transfer oscillator. The technique can be used to measure frequency ratios of any optical signals throughout…

光学 · 物理学 2009-11-07 Jörn Stenger , Harald Schnatz , Christian Tamm , Harald R. Telle

Hyperspectral imaging provides spatially resolved spectral information. Utilising dual frequency combs as active illumination sources, hyperspectral imaging with ultra-high spectral resolution can be implemented in a scan-free manner when a…

Improving the resolution of fluorescence microscopy beyond the diffraction limit can be achievedby acquiring and processing multiple images of the sample under different illumination conditions.One of the simplest techniques, Random…

Frequency comb spectroscopy provides broadband access to molecular fingerprints with mode-defined spectral resolution. However, its deployment in non-cooperative gas sensing remains challenging because conventional implementations require…

Optical frequency-comb-based-high-resolution spectrometers offer enormous potential for spectroscopic applications. Although various implementations have been demonstrated, the lack of suitable mid-infrared comb sources has impeded…