相关论文: Independent components of human brain morphology
The universal scaling law of cortical morphology describes cortical folding as the covariance of average grey matter thickness, pial surface area, and exposed surface area. It applies for mammalian species, humans, and across lobes, however…
Background: We have previously demonstrated that cortical folding across mammalian species follows a universal scaling law that can be derived from a simple theoretical model. The same scaling law has also been shown to hold across brains…
The human brain cortical layer has a convoluted morphology that is unique to each individual. Characterization of the cortical morphology is necessary in longitudinal studies of structural brain change, as well as in discriminating…
Motivation: Characterising the changes in cortical morphology across the lifespan is fundamental for a range of research and clinical applications. Most studies to date have found a monotonic decrease in commonly used morphometrics, such as…
The human brain cortical layer has a convoluted morphology that is unique to each individual. Characterization of the cortical morphology is necessary in longitudinal studies of structural brain change, as well as in discriminating…
Structural covariance analysis is a widely used structural MRI analysis method which characterises the co-relations of morphology between brain regions over a group of subjects. To our knowledge, little has been investigated in terms of the…
The geometry of the human cortex is complex and highly variable, with interactions between brain size, cortical folding, and age well-documented in the literature. However, few studies have explored how global brain size influences…
Brain morphometry study plays a fundamental role in neuroimaging research. In this work, we propose a novel method for brain surface morphometry analysis based on surface foliation theory. Given brain cortical surfaces with automatically…
For long it has been known that specific patterns of folding are necessary for an optimally functioning brain. For instance, lissencephaly and polymicrogyria can lead to severe mental retardation, short life expectancy, epileptic seizures,…
The surface morphology of the developing mammalian brain is crucial for understanding brain function and dysfunction. Computational modeling offers valuable insights into the underlying mechanisms for early brain folding. Recent findings…
Abnormal cortical folding patterns may be related to neurodevelopmental disorders such as lissencephaly and polymicrogyria. In this context, computational modeling is a powerful tool to provide a better understanding of the early brain…
Normative models of brain structure estimate the effects of covariates such as age and sex using large samples of healthy controls. These models can then be applied to e.g. smaller clinical cohorts to distinguish disease effects from other…
The cerebral cortex performs higher-order brain functions and is thus implicated in a range of cognitive disorders. Current analysis of cortical variation is typically performed by fitting surface mesh models to inner and outer cortical…
Converging research suggests that the resting brain operates at the cusp of dynamic instability signified by scale-free temporal correlations. We asked if the scaling properties of these correlations differ between amplitude and phase…
Surface analysis of the cortex is ubiquitous in human neuroimaging with MRI, e.g., for cortical registration, parcellation, or thickness estimation. The convoluted cortical geometry requires isotropic scans (e.g., 1mm MPRAGEs) and good…
Cortical folding pattern is a main characteristic of the geometry of the human brain which is formed by gyri (ridges) and sulci (grooves). Several biological hypotheses have suggested different mechanisms that attempt to explain the…
Adaptive behavior, cognition and emotion are the result of a bewildering variety of brain spatiotemporal activity patterns. An important problem in neuroscience is to understand the mechanism by which the human brain's 100 billion neurons…
The cerebral cortex displays a bewildering diversity of shapes and sizes across and within species. Despite this diversity, we present a universal multi-scale description of primate cortices. We show that all cortical shapes can be…
We develop a new approach to characterizing the morphology of rough surfaces based on the analysis of the scaling properties of contour loops, i.e. loops of constant height. Given a height profile of the surface we perform independent…
Real cortical tissue curves and folds according to experimental data. However, our current simulations only use unfolded cortical layers. This project extends the cortical slice model in order to be able to specify arbitrary curvatures to…