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Myosin motor proteins drive vigorous steady-state fluctuations in the actin cytoskeleton of cells. Endogenous embedded semiflexible filaments such as microtubules, or added filaments such as single-walled carbon nanotubes are used as novel…

生物物理 · 物理学 2016-06-21 J. Gladrow , N. Fakhri , F. C. MacKintosh , C. F. Schmidt , C. P. Broedersz

Many lipid membrane-mediated transport processes--such as mechanically-gated channel activation and solute transport--involve structural and dynamical features on membrane thickness length scales. Most existing membrane models, however,…

软凝聚态物质 · 物理学 2025-08-29 Zachary G. Lipel , Yannick A. D. Omar , Dimitrios Fraggedakis

We analyze the non-equilibrium shape fluctuations of giant unilamellar vesicles encapsulating motile bacteria. Owing to bacteria--membrane collisions, we experimentally observe a significant increase in the magnitude of membrane…

软凝聚态物质 · 物理学 2020-04-22 Sho C. Takatori , Amaresh Sahu

Biological activity gives rise to non-equilibrium fluctuations in the cytoplasm of cells; however, there are few methods to directly measure these fluctuations. Using a reconstituted actin cytoskeleton, we show that the bending dynamics of…

软凝聚态物质 · 物理学 2009-11-13 C. P. Brangwynne , G. H. Koenderink , F. C. MacKintosh , D. A. Weitz

We investigate the effect of thermal fluctuations on the mechanical properties of nanotubes by employing tools from statistical physics. For 2D sheets it was previously shown that thermal fluctuations effectively renormalize elastic moduli…

统计力学 · 物理学 2023-05-25 Siddhartha Sarkar , Mohamed El Hedi Bahri , Andrej Košmrlj

Active contributions to fluctuations are a direct consequence of metabolic energy consumption in living cells. Such metabolic processes continuously create active forces, which deform the membrane to control motility, proliferation as well…

生物物理 · 物理学 2018-10-02 Hervé Turlier , Timo Betz

Cell shape changes are largely controlled by the actin cytoskeleton, a dynamic filament network beneath the plasma membrane. Several cell types can form extended free-standing protrusions not supported by an extracellular substrate or…

软凝聚态物质 · 物理学 2025-10-21 Kristiana Mihali , Dennis Wörthmüller , Pierre Sens

The growth of actin filament networks is a fundamental biological process that drives a variety of cellular and intracellular motions. During motility, eukaryotic cells and intracellular pathogens are propelled by actin networks organized…

生物物理 · 物理学 2009-11-13 Joshua W. Shaevitz , Daniel A. Fletcher

Optical tweezers allow the measurement of fluctuations at the nano-scale, in particular fluctuations in the end-to-end distance in single molecules. Fluctuation spectra can yield valuable information, but they can easily be contaminated by…

生物物理 · 物理学 2015-09-30 Marco Ribezzi-Crivellari , Anna Alemany , Felix Ritort

We theoretically investigate the membrane fluctuations of red blood cells with focus laid on the role of the cytoskeleton, viewing the system as a membrane coupled to sparse spring network. This model is exactly solvable and enables us to…

软凝聚态物质 · 物理学 2015-08-31 Wonjune Choi , Juyeon Yi , Yong Woon Kim

Superconducting fluctuations in long and narrow strips made from ultrathin NbN films, have been investigated. For large bias currents close to the critical current fluctuations led to localized, temporary transitions into the normal…

超导电性 · 物理学 2010-03-25 A. Engel , A. D. Semenov , H. -W. Huebers , K. Il'in , M. Siegel

Polymerization of actin proteins into dynamic structures is essential to eukaryotic cell life. This has motivated a large body of in vitro experiments measuring polymerization kinetics of individual filaments. Here we model these kinetics,…

生物大分子 · 定量生物学 2009-11-10 Dimitrios Vavylonis , Qingbo Yang , Ben O'Shaughnessy

The mammalian cell membrane is embedded with biomolecular condensates of protein and lipid clusters, which interact with an underlying viscoelastic cytoskeleton network to organize the cell surface and mechanically interact with the…

软凝聚态物质 · 物理学 2024-10-23 Daniel P. Arnold , Sho C. Takatori

We calculate the fluctuation spectrum of the shape of a lipid vesicle or cell exposed to a nonthermal source of noise. In particular we take into account constraints on the membrane area and the volume of fluid that it encapsulates when…

软凝聚态物质 · 物理学 2013-11-07 Bastien Loubet , Udo Seifert , Michael Andersen Lomholt

We investigate the effect of stress fluctuations on the stochastic dynamics of an inclusion embedded in a viscous gel. We show that, in non-equilibrium systems, stress fluctuations give rise to an effective attraction towards the boundaries…

Two-dimensional crystalline membranes have recently been realized experimentally in such systems as graphene and molybdenum disulfide, sparking a resurgence in interest in their statistical properties. Thermal fluctuations can significantly…

软凝聚态物质 · 物理学 2017-07-19 Emily Russell , Rastko Sknepnek , Mark J. Bowick

Dynamics of double membrane films is investigated in the long-wavelength limit including the overdamped squeezing mode. We demonstrate that thermal fluctuations essentially modify the character of the mode due to its nonlinear coupling to…

软凝聚态物质 · 物理学 2009-10-30 E. I. Kats , V. V. Lebedev , S. V. Malinin

We present a detailed analysis of the micropipet experiments recently reported in J-B. Manneville et al., Phys. Rev. Lett. 82, 4356--4359 (1999), including a derivation of the expected behaviour of the membrane tension as a function of the…

软凝聚态物质 · 物理学 2009-11-07 J-B. Manneville , P. Bassereau , S. Ramaswamy , J. Prost

We report on the effect of intermolecular forces on the fluctuations of supported liquid films. Using an optically-induced thermal gradient, we form nanometer-thin films of wetting liquids on glass substrates, where van der Waals forces are…

软凝聚态物质 · 物理学 2021-06-08 C. Clavaud , M. Maza-Cuello , C. Frétigny , L. Talini , T. Bickel
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