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We present a self-supervised algorithm for several classification tasks within hematoxylin and eosin (H&E) stained images of breast cancer. Our method is robust to stain variations inherent to the histology images acquisition process, which…

计算机视觉与模式识别 · 计算机科学 2023-09-08 Alexandre Tiard , Alex Wong , David Joon Ho , Yangchao Wu , Eliram Nof , Alvin C. Goh , Stefano Soatto , Saad Nadeem

Hematoxylin and Eosin (H&E) has been the gold standard in tissue analysis for decades, however, tissue specimens stained in different laboratories vary, often significantly, in appearance. This variation poses a challenge for both…

图像与视频处理 · 电气工程与系统科学 2025-06-25 Umair Khan , Jouni Härkönen , Marjukka Friman , Leena Latonen , Teijo Kuopio , Pekka Ruusuvuori

Histopathological cancer diagnosis is based on visual examination of stained tissue slides. Hematoxylin and eosin (H\&E) is a standard stain routinely employed worldwide. It is easy to acquire and cost effective, but cells and tissue…

计算机视觉与模式识别 · 计算机科学 2022-07-12 Zhaoyang Xu , Xingru Huang , Carlos Fernández Moro , Béla Bozóky , Qianni Zhang

While hematoxylin and eosin (H&E) is a standard staining procedure, immunohistochemistry (IHC) staining further serves as a diagnostic and prognostic method. However, acquiring special staining results requires substantial costs. Hence, we…

计算机视觉与模式识别 · 计算机科学 2022-08-30 Ming-Yang Ho , Min-Sheng Wu , Che-Ming Wu

In this paper, we develop a complete pipeline for stain normalization, segmentation, and classification of nuclei in hematoxylin and eosin (H&E) stained breast cancer histopathology images. In the first step, we use a CNN-based stain…

计算机视觉与模式识别 · 计算机科学 2018-11-12 Edwin Yuan , Junkyo Suh

Image-to-image translation (I2I) methods allow the generation of artificial images that share the content of the original image but have a different style. With the advances in Generative Adversarial Networks (GANs)-based methods, I2I…

图像与视频处理 · 电气工程与系统科学 2023-04-07 Igor Zingman , Sergio Frayle , Ivan Tankoyeu , Segrey Sukhanov , Fabian Heinemann

Performance of data-driven network for tumor classification varies with stain-style of histopathological images. This article proposes the stain-style transfer (SST) model based on conditional generative adversarial networks (GANs) which is…

计算机视觉与模式识别 · 计算机科学 2018-12-21 Hyungjoo Cho , Sungbin Lim , Gunho Choi , Hyunseok Min

Digitized Histological diagnosis is in increasing demand. However, color variations due to various factors are imposing obstacles to the diagnosis process. The problem of stain color variations is a well-defined problem with many proposed…

计算机视觉与模式识别 · 计算机科学 2018-04-06 M Tarek Shaban , Christoph Baur , Nassir Navab , Shadi Albarqouni

Histopathology relies on the analysis of microscopic tissue images to diagnose disease. A crucial part of tissue preparation is staining whereby a dye is used to make the salient tissue components more distinguishable. However, differences…

图像与视频处理 · 电气工程与系统科学 2022-08-03 Haseeb Nazki , Ognjen Arandjelović , InHwa Um , David Harrison

Stain normalization often refers to transferring the color distribution of the source image to that of the target image and has been widely used in biomedical image analysis. The conventional stain normalization is regarded as constructing…

图像与视频处理 · 电气工程与系统科学 2021-11-09 Hongtao Kang , Die Luo , Weihua Feng , Junbo Hu , Shaoqun Zeng , Tingwei Quan , Xiuli Liu

Virtual stain transfer is a promising area of research in Computational Pathology, which has a great potential to alleviate important limitations when applying deeplearningbased solutions such as lack of annotations and sensitivity to a…

计算机视觉与模式识别 · 计算机科学 2022-10-19 Jelica Vasiljević , Friedrich Feuerhake , Cédric Wemmert , Thomas Lampert

Computational analysis of multiplexed immunofluorescence histology data is emerging as an important method for understanding the tumour micro-environment in cancer. This work presents HEMIT, a dataset designed for translating Hematoxylin…

图像与视频处理 · 电气工程与系统科学 2024-09-30 Chang Bian , Beth Philips , Tim Cootes , Martin Fergie

Unsupervised and unpaired domain translation using generative adversarial neural networks, and more precisely CycleGAN, is state of the art for the stain translation of histopathology images. It often, however, suffers from the presence of…

计算机视觉与模式识别 · 计算机科学 2022-07-04 Nicolas Brieu , Felix J. Segerer , Ansh Kapil , Philipp Wortmann , Guenter Schmidt

Breast cancer early detection is crucial for improving patient outcomes. The Institut Catal\`a de la Salut (ICS) has launched the DigiPatICS project to develop and implement artificial intelligence algorithms to assist with the diagnosis of…

图像与视频处理 · 电气工程与系统科学 2023-05-15 David Anglada-Rotger , Ferran Marqués , Montse Pardàs

Breast cancer presents a significant healthcare challenge globally, demanding precise diagnostics and effective treatment strategies, where histopathological examination of Hematoxylin and Eosin (H&E) stained tissue sections plays a central…

图像与视频处理 · 电气工程与系统科学 2024-08-06 Linhao Qu , Chengsheng Zhang , Guihui Li , Haiyong Zheng , Chen Peng , Wei He

In digital pathology, different staining procedures and scanners cause substantial color variations in whole-slide images (WSIs), especially across different laboratories. These color shifts result in a poor generalization of deep…

图像与视频处理 · 电气工程与系统科学 2021-07-27 Sophia J. Wagner , Nadieh Khalili , Raghav Sharma , Melanie Boxberg , Carsten Marr , Walter de Back , Tingying Peng

Stain normalization algorithms aim to transform the color and intensity characteristics of a source multi-gigapixel histology image to match those of a target image, mitigating inconsistencies in the appearance of stains used to highlight…

图像与视频处理 · 电气工程与系统科学 2024-07-15 Robert Jewsbury , Ruoyu Wang , Abhir Bhalerao , Nasir Rajpoot , Quoc Dang Vu

Histopathological diagnoses of tumors in tissue biopsy after Hematoxylin and Eosin (H&E) staining is the gold standard for oncology care. H&E staining is slow and uses dyes, reagents and precious tissue samples that cannot be reused.…

Hematoxylin and Eosin (H&E) staining is widely regarded as the standard in pathology for diagnosing diseases and tracking tumor recurrence. While H&E staining shows tissue structures, it lacks the ability to reveal specific proteins that…

图像与视频处理 · 电气工程与系统科学 2025-05-21 Tushar Kataria , Beatrice Knudsen , Shireen Y. Elhabian

Hematoxylin and eosin (H&E) staining is the clinical standard for assessing tissue morphology, but it lacks molecular-level diagnostic information. In contrast, immunohistochemistry (IHC) provides crucial insights into biomarker expression,…

图像与视频处理 · 电气工程与系统科学 2025-08-05 Jingsong Liu , Xiaofeng Deng , Han Li , Azar Kazemi , Christian Grashei , Gesa Wilkens , Xin You , Tanja Groll , Nassir Navab , Carolin Mogler , Peter J. Schüffler
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