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Breast cancer is a highly heterogeneous disease with diverse molecular profiles. The PAM50 gene signature is widely recognized as a standard for classifying breast cancer into intrinsic subtypes, enabling more personalized treatment…

While machine learning is currently transforming the field of histopathology, the domain lacks a comprehensive evaluation of state-of-the-art models based on essential but complementary quality requirements beyond a mere classification…

图像与视频处理 · 电气工程与系统科学 2023-05-11 Maximilian Springenberg , Annika Frommholz , Markus Wenzel , Eva Weicken , Jackie Ma , Nils Strodthoff

The early detection, diagnosis and monitoring of liver cancer progression can be achieved with the precise delineation of metastatic tumours. However, accurate automated segmentation remains challenging due to the presence of noise,…

机器学习 · 计算机科学 2015-09-02 Samuel Kadoury , Eugene Vorontsov , An Tang

Making histopathology image classifiers robust to a wide range of real-world variability is a challenging task. Here, we describe a candidate deep learning solution for the Mitosis Domain Generalization Challenge 2022 (MIDOG) to address the…

图像与视频处理 · 电气工程与系统科学 2023-01-04 Maxime W. Lafarge , Viktor H. Koelzer

This project aims to break down large pathology images into small tiles and then cluster those tiles into distinct groups without the knowledge of true labels, our analysis shows how difficult certain aspects of clustering tumorous and…

图像与视频处理 · 电气工程与系统科学 2020-12-29 Mostafa Ibrahim , Kevin Bryson

Throughout the world, breast cancer is one of the leading causes of female death. Recently, deep learning methods are developed to automatically grade breast cancer of histological slides. However, the performance of existing deep learning…

计算机视觉与模式识别 · 计算机科学 2022-03-09 Yanyuet Man , Xiangyun Ding , Xingcheng Yao , Han Bao

Histopathological image analysis is the gold standard to diagnose cancer. Carcinoma is a subtype of cancer that constitutes more than 80% of all cancer cases. Squamous cell carcinoma and adenocarcinoma are two major subtypes of carcinoma,…

图像与视频处理 · 电气工程与系统科学 2022-01-20 Swathi Prabhua , Keerthana Prasada , Antonio Robels-Kelly , Xuequan Lu

Skin lesion is a severe disease in world-wide extent. Early detection of melanoma in dermoscopy images significantly increases the survival rate. However, the accurate recognition of melanoma is extremely challenging due to the following…

计算机视觉与模式识别 · 计算机科学 2017-11-23 Yuexiang Li , Linlin Shen

Recent years have seen great advancements in the development of deep learning models for histopathology image analysis in digital pathology applications, evidenced by the increasingly common deployment of these models in both research and…

图像与视频处理 · 电气工程与系统科学 2022-08-09 Veena Kaustaban , Qinle Ba , Ipshita Bhattacharya , Nahil Sobh , Satarupa Mukherjee , Jim Martin , Mohammad Saleh Miri , Christoph Guetter , Amal Chaturvedi

Histopathological imaging is vital for cancer research and clinical practice, with multiplexed Immunofluorescence (MxIF) and Hematoxylin and Eosin (H&E) providing complementary insights. However, aligning different stains at the cell level…

图像与视频处理 · 电气工程与系统科学 2024-10-02 Jun Jiang , Raymond Moore , Brenna Novotny , Leo Liu , Zachary Fogarty , Ray Guo , Markovic Svetomir , Chen Wang

Definitive cancer diagnosis and management depend upon the extraction of information from microscopy images by pathologists. These images contain complex information requiring time-consuming expert human interpretation that is prone to…

For diagnosing melanoma, hematoxylin and eosin (H&E) stained tissue slides remains the gold standard. These images contain quantitative information in different magnifications. In the present study, we investigated whether deep…

组织与器官 · 定量生物学 2019-04-15 Peizhen Xie , Ke Zuo , Yu Zhang , Fangfang Li , Mingzhu Yin , Kai Lu

This paper addresses the problem of liver cancer segmentation in Whole Slide Image (WSI). We propose a multi-scale image processing method based on automatic end-to-end deep neural network algorithm for segmentation of cancer area. A…

图像与视频处理 · 电气工程与系统科学 2020-07-29 Yanbo Feng , Adel Hafiane , Hélène Laurent

Deep neural networks have introduced significant advancements in the field of machine learning-based analysis of digital pathology images including prostate tissue images. With the help of transfer learning, classification and segmentation…

Automated segmentation of cancerous lesions in PET/CT scans is a crucial first step in quantitative image analysis. However, training deep learning models for segmentation with high accuracy is particularly challenging due to the variations…

计算机视觉与模式识别 · 计算机科学 2024-09-17 Shadab Ahamed

The analysis of the tumor environment on digital histopathology slides is becoming key for the understanding of the immune response against cancer, supporting the development of novel immuno-therapies. We introduce here a novel deep…

图像与视频处理 · 电气工程与系统科学 2019-06-27 Ansh Kapil , Tobias Wiestler , Simon Lanzmich , Abraham Silva , Keith Steele , Marlon Rebelatto , Guenter Schmidt , Nicolas Brieu

Gastric cancer ranks as the fifth most common and fourth most lethal cancer globally, with a dismal 5-year survival rate of approximately 20%. Despite extensive research on its pathobiology, the prognostic predictability remains inadequate,…

图像与视频处理 · 电气工程与系统科学 2025-03-24 Marco Usai , Andrea Loddo , Alessandra Perniciano , Maurizio Atzori , Cecilia Di Ruberto

Mammography stands as the main screening method for detecting breast cancer early, enhancing treatment success rates. The segmentation of landmark structures in mammography images can aid the medical assessment in the evaluation of cancer…

图像与视频处理 · 电气工程与系统科学 2025-03-31 Jan Hurtado , Joao P. Maia , Cesar A. Sierra-Franco , Alberto Raposo

Delineation of cancerous regions in gigapixel whole slide images (WSIs) is a crucial diagnostic procedure in digital pathology. This process is time-consuming because of the large search space in the gigapixel WSIs, causing chances of…

图像与视频处理 · 电气工程与系统科学 2020-07-21 Hsien-Tzu Cheng , Chun-Fu Yeh , Po-Chen Kuo , Andy Wei , Keng-Chi Liu , Mong-Chi Ko , Kuan-Hua Chao , Yu-Ching Peng , Tyng-Luh Liu

Recent studies have shown promising results in using Deep Learning to detect malignancy in whole slide imaging. However, they were limited to just predicting positive or negative finding for a specific neoplasm. We attempted to use Deep…

计算机视觉与模式识别 · 计算机科学 2018-11-08 Hanadi El Achi , Tatiana Belousova , Lei Chen , Amer Wahed , Iris Wang , Zhihong Hu , Zeyad Kanaan , Adan Rios , Andy N. D. Nguyen