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Conventional survival analysis approaches estimate risk scores or individualized time-to-event distributions conditioned on covariates. In practice, there is often great population-level phenotypic heterogeneity, resulting from (unknown)…

机器学习 · 统计学 2020-03-03 Paidamoyo Chapfuwa , Chunyuan Li , Nikhil Mehta , Lawrence Carin , Ricardo Henao

Semi-supervised clustering is the task of clustering data points into clusters where only a fraction of the points are labelled. The true number of clusters in the data is often unknown and most models require this parameter as an input.…

机器学习 · 计算机科学 2013-09-27 Amar Shah , Zoubin Ghahramani

We propose a Bayesian approach for model-based clustering of multivariate categorical data where variables are allowed to be associated within clusters and the number of clusters is unknown. The approach uses a two-layer mixture of finite…

统计方法学 · 统计学 2024-07-09 Gertraud Malsiner-Walli , Bettina Grün , Sylvia Frühwirth-Schnatter

Inter-subject variability between individuals poses a challenge in inter-subject brain signal analysis problems. A new algorithm for subject-selection based on clustering covariance matrices on a Riemannian manifold is proposed. After…

机器学习 · 计算机科学 2017-12-05 Samaneh Nasiri Ghosheh Bolagh , Gari. D. Clifford

Spectral Clustering (SC) is one of the most widely used methods for data clustering. It first finds a low-dimensonal embedding $U$ of data by computing the eigenvectors of the normalized Laplacian matrix, and then performs k-means on…

计算机视觉与模式识别 · 计算机科学 2018-05-29 Canyi Lu , Shuicheng Yan , Zhouchen Lin

Subspace clustering methods which embrace a self-expressive model that represents each data point as a linear combination of other data points in the dataset provide powerful unsupervised learning techniques. However, when dealing with…

计算机视觉与模式识别 · 计算机科学 2023-10-06 Katsuya Hotta , Takuya Akashi , Shogo Tokai , Chao Zhang

The paper is motivated from clustering problem in high-throughput mixed datasets. Clustering of such datasets can provide much insight into biological associations. An open problem in this context is to simultaneously cluster…

统计方法学 · 统计学 2018-08-15 Chetkar Jha

Bi-clustering is a useful approach in analyzing biological data when observations come from heterogeneous groups and have a large number of features. We outline a general Bayesian approach in tackling bi-clustering problems in moderate to…

应用统计 · 统计学 2021-02-11 Han Yan , Jiexing Wu , Yang Li , Jun S. Liu

We present a Bayesian nonparametric framework for multilevel clustering which utilizes group-level context information to simultaneously discover low-dimensional structures of the group contents and partitions groups into clusters. Using…

机器学习 · 计算机科学 2014-01-30 Vu Nguyen , Dinh Phung , XuanLong Nguyen , Svetha Venkatesh , Hung Hai Bui

Clustering of single-cell RNA sequencing (scRNA-seq) datasets can give key insights into the biological functions of cells. Therefore, it is not surprising that network-based community detection methods (one of the better clustering…

统计方法学 · 统计学 2026-02-17 Chetkar Jha , Mingyao Li , Ian Barnett

Modern high-throughput sequencing technologies have enabled us to profile multiple molecular modalities from the same single cell, providing unprecedented opportunities to assay celluar heterogeneity from multiple biological layers.…

机器学习 · 统计学 2022-05-20 Pengcheng Zeng , Zhixiang Lin

Sparse subspace clustering (SSC) is an elegant approach for unsupervised segmentation if the data points of each cluster are located in linear subspaces. This model applies, for instance, in motion segmentation if some restrictions on the…

机器学习 · 统计学 2018-02-12 Hanno Ackermann , Michael Ying Yang , Bodo Rosenhahn

We propose a novel method, scTree, for single-cell Tree Variational Autoencoders, extending a hierarchical clustering approach to single-cell RNA sequencing data. scTree corrects for batch effects while simultaneously learning a…

机器学习 · 计算机科学 2024-07-11 Moritz Vandenhirtz , Florian Barkmann , Laura Manduchi , Julia E. Vogt , Valentina Boeva

With ongoing developments and innovations in single-cell RNA sequencing methods, advancements in sequencing performance could empower significant discoveries as well as new emerging possibilities to address biological and medical…

应用统计 · 统计学 2019-12-19 Jiawei Long , Yu Xia

State-of-the-art subspace clustering methods are based on self-expressive model, which represents each data point as a linear combination of other data points. By enforcing such representation to be sparse, sparse subspace clustering is…

机器学习 · 计算机科学 2020-05-05 Ying Chen , Chun-Guang Li , Chong You

Single-molecule spectroscopy (SMS) is an exceptionally sensitive technique, but its inherently limited photon budget produces noisy data that can readily lead to subjective analyses, fitting errors, and reduced statistical power, obscuring…

生物物理 · 物理学 2026-03-19 Michael Lovemore , Joshua Botha , Bertus van Heerden , Tjaart Kruger

Size-constrained clustering (SCC) refers to the dual problem of using observations to determine latent cluster structure while at the same time assigning observations to the unknown clusters subject to an analyst defined constraint on…

应用统计 · 统计学 2017-10-18 Justin D. Silverman , Rachel K. Silverman

In settings where only unlabelled speech data is available, zero-resource speech technology needs to be developed without transcriptions, pronunciation dictionaries, or language modelling text. There are two central problems in…

计算与语言 · 计算机科学 2017-01-05 Herman Kamper

In this paper, we introduce a neural network framework for semi-supervised clustering (SSC) with pairwise (must-link or cannot-link) constraints. In contrast to existing approaches, we decompose SSC into two simpler classification…

机器学习 · 计算机科学 2020-01-22 Marek Śmieja , Łukasz Struski , Mário A. T. Figueiredo

Single-cell RNA sequencing (scRNA-seq) is essential for unraveling cellular heterogeneity and diversity, offering invaluable insights for bioinformatics advancements. Despite its potential, traditional clustering methods in scRNA-seq data…

机器学习 · 计算机科学 2025-10-01 Ping Xu , Zhiyuan Ning , Meng Xiao , Guihai Feng , Xin Li , Yuanchun Zhou , Pengfei Wang