相关论文: Improving Neural Protein-Protein Interaction Extra…

Geometric deep learning has recently achieved great success in non-Euclidean domains, and learning on 3D structures of large biomolecules is emerging as a distinct research area. However, its efficacy is largely constrained due to the…

Enriching existing medical terminology knowledge bases (KBs) is an important and never-ending work for clinical research because new terminology alias may be continually added and standard terminologies may be newly renamed. In this paper,…

Existing data-centric methods for protein science generally cannot sufficiently capture and leverage biology knowledge, which may be crucial for many protein tasks. To facilitate research in this field, we create ProteinKG65, a knowledge…

Accurate prediction of protein-ligand binding affinity is critical for drug discovery. While recent deep learning approaches have demonstrated promising results, they often rely solely on structural features of proteins and ligands,…

Retrieving the biological impacts of protein-protein interactions (PPIs) is essential for target identification (Target ID) in drug development. Given the vast number of proteins involved, this process remains time-consuming and…

As the use of interactive machines grow, the task of Emotion Recognition in Conversation (ERC) became more important. If the machine-generated sentences reflect emotion, more human-like sympathetic conversations are possible. Since emotion…

Passage re-ranking is to obtain a permutation over the candidate passage set from retrieval stage. Re-rankers have been boomed by Pre-trained Language Models (PLMs) due to their overwhelming advantages in natural language understanding.…

Protein-protein interaction (PPI) networks consist of the physical and/or functional interactions between the proteins of an organism. Since the biophysical and high-throughput methods used to form PPI networks are expensive,…

Peptides play a pivotal role in a wide range of biological activities through participating in up to 40% protein-protein interactions in cellular processes. They also demonstrate remarkable specificity and efficacy, making them promising…

Motivation: Protein-protein interactions (PPIs) are usually modelled as networks. These networks have extensively been studied using graphlets, small induced subgraphs capturing the local wiring patterns around nodes in networks. They…

Relation detection is a core component for many NLP applications including Knowledge Base Question Answering (KBQA). In this paper, we propose a hierarchical recurrent neural network enhanced by residual learning that detects KB relations…

Pre-trained language models (PLMs) have demonstrated strong performance in sequential recommendation (SR), which are utilized to extract general knowledge. However, existing methods still lack domain knowledge and struggle to capture users'…

Protein language models have emerged as powerful tools for sequence generation, offering substantial advantages in functional optimization and denovo design. However, these models also present significant risks of generating harmful protein…

Relational knowledge bases (KBs) are commonly used to represent world knowledge in machines. However, while advantageous for their high degree of precision and interpretability, KBs are usually organized according to manually-defined…

Recent studies on knowledge graph embedding focus on mapping entities and relations into low-dimensional vector spaces. While most existing models primarily exploit structural information, knowledge graphs also contain rich contextual and…

Knowledge bases, and their representations in the form of knowledge graphs (KGs), are naturally incomplete. Since scientific and industrial applications have extensively adopted them, there is a high demand for solutions that complete their…

Motivation: Biomedical event detection is fundamental for information extraction in molecular biology and biomedical research. The detected events form the central basis for comprehensive biomedical knowledge fusion, facilitating the…

We participated in three of the protein-protein interaction subtasks of the Second BioCreative Challenge: classification of abstracts relevant for protein-protein interaction (IAS), discovery of protein pairs (IPS) and text passages…

Pre-trained language models (PLMs) have proven to be effective for document re-ranking task. However, they lack the ability to fully interpret the semantics of biomedical and health-care queries and often rely on simplistic patterns for…

With the advent of high-throughput wet lab technologies the amount of protein interaction data available publicly has increased substantially, in turn spurring a plethora of computational methods for in silico knowledge discovery from this…