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As an emerging technology, transcranial focused ultrasound has been demonstrated to successfully evoke motor responses in mice, rabbits, and sensory/motor responses in humans. Yet, the spatial resolution of ultrasound does not allow for…

神经元与认知 · 定量生物学 2020-12-21 Linli Shi , Ying Jiang , Fernando R. Fernandez , Lu Lan , Guo Chen , Heng-ye Man , John A. White , Ji-Xin Cheng , Chen Yang

A bidirectional brain interface with both "write" and "read" functions can be an important tool for fundamental studies and potential clinical treatments for neurological diseases. Here we report a miniaturized multifunctional fiber based…

神经元与认知 · 定量生物学 2023-01-11 Nan Zheng , Ying Jiang , Shan Jiang , Jongwoon Kim , Yueming Li , Ji-Xin Cheng , Xiaoting Jia , Chen Yang

Photoacoustic microscopy (PAM) is a promising imaging modality because it is able to reveal optical absorption contrast in high resolution on the order of a micrometer. It can be applied in an endoscopic approach by implementing PAM into a…

医学物理 · 物理学 2019-11-22 Zhendong Guo , Zhanhong Ye , Weihao Shao , Lili Jing , Sung-Liang Chen

Acoustoelectric (AE) imaging provides electro-anatomical contrast by mapping the distribution of electric fields in biological tissues, by delivering ultrasound waves which spatially modulate the medium resistivity via the AE effect. The…

图像与视频处理 · 电气工程与系统科学 2025-12-17 Wei Yi Oon , Yuchen Tang , Baiqian Qi , Wei-Ning Lee

Opto-mechanical oscillators that generate coherent acoustic waves are drawing much interest, in both fundamental research and applications. Narrowband oscillations can be obtained through the introduction of feedback to the acoustic wave.…

光学 · 物理学 2018-11-16 H. Hagai Diamandi , Yosef London , Gil Bashan , Arik Bergman , Avi Zadok

We propose a focusing method of intense midair ultrasound out of ultrasonic emission from a single flexurally vibrating square plate partially covered with a purposely designed amplitude mask. Many applications relying on nonlinear acoustic…

应用物理 · 物理学 2024-06-04 Keisuke Hasegawa , Masaya Fujimori , Masaya Takasaki

An opto-electronic radio-frequency oscillator that is based on forward scattering by the guided acoustic modes of a standard single-mode optical fiber is proposed and demonstrated. An optical pump wave is used to stimulate narrowband,…

应用物理 · 物理学 2019-02-15 Yosef London , Hilel Hagai Diamandi , Avi Zadok

We propose a low noise, triply-resonant, electro-optic (EO) scheme for quantum microwave-to-optical conversion based on coupled nanophotonics resonators integrated with a superconducting qubit. Our optical system features a split resonance…

量子物理 · 物理学 2017-11-02 Mohammad Soltani , Mian Zhang , Colm A. Ryan , Guilhem J. Ribeill , Cheng Wang , Marko Loncar

Optical wireless communication (OWC) leverages the terahertz-scale optical spectrum to enable ultra-fast data transfer, offering a compelling alternative to often-congested radio frequency systems. However, the highly directional nature of…

系统与控制 · 电气工程与系统科学 2025-08-19 Hongwei Cui , Soung Chang Liew

High-frequency focused ultrasound is widely used in biomedical applications such as high-resolution imaging, neuromodulation, particle manipulation, and so on. However, dynamic tuning of the focal plane in conventional systems often relies…

应用物理 · 物理学 2026-04-15 Shiyu Li , Yicheng Feng , Weiwei Cui , Zhixiong Gong

Point-like broadband ultrasound detection can significantly increase the resolution of ultrasonography and optoacoustic (photoacoustic) imaging, yet current ultrasound detectors cannot be miniaturised sufficiently. Piezoelectric transducers…

Synchronously pumped optical parametric oscillators (OPOs) provide uniquely versatile platforms to generate ultrafast mid-infrared pulses within a spectral range beyond the access of conventional mode-locked lasers. However, conventional…

光学 · 物理学 2026-05-27 Tingting Yu , Jianan Fang , Kun Huang , Heping Zeng

We have developed a novel in vitro instrument that can deliver intermediate frequency (100 - 400 kHz), moderate intensity (up to and exceeding 6.5 V/cm pk-pk) electric fields (EFs) to cell and tissue cultures generated using induced…

Compact, ultra-low phase noise 10 GHz signals are essential for modern radar, coherent communications, and time-frequency metrology, especially with rising demands for additional spectral purity and portability. Optical frequency division…

Acoustical tweezers based on focalized acoustical vortices hold the promise of precise contactless 3D manipulation of millimeter down to sub-micrometer particles, microorganisms and cells with unprecedented combined selectivity and trapping…

Light-sound interactions have long been exploited in various acousto-optic devices based on bulk crystalline materials. Conventionally these devices operate in megahertz frequency range where the acoustic wavelength is much longer than the…

光学 · 物理学 2015-04-06 Semere Ayalew Tadesse , Mo Li

Non-invasive stimulation of small, variably shaped brain sub-regions is crucial for advancing our understanding of brain functions. Current ultrasound neuromodulation faces two significant trade-offs when targeting brain sub-regions:…

Focusing light into opaque random or scattering media such as biological tissue is a much sought-after goal for biomedical applications such as photodynamic therapy, optical manipulation, and photostimulation. However, focusing with…

光学 · 物理学 2014-03-10 Jian Wei Tay , Puxiang Lai , Yuta Suzuki , Lihong V. Wang

High precision neuromodulation is a powerful tool to decipher neurocircuits and treat neurological diseases. Current non-invasive neuromodulation methods offer limited precision at the millimeter level. Here, we report optically-generated…

神经元与认知 · 定量生物学 2022-11-07 Yueming Li , Ying Jiang , Lu Lan , Xiaowei Ge , Ran Cheng , Yuewei Zhan , Guo Chen , Linli Shi , Runyu Wang , Nan Zheng , Chen Yang , Ji-Xin Cheng

The penetration depth of photoacoustic imaging in biological tissues has been fundamentally limited by the strong optical attenuation when light is delivered externally through the tissue surface. To address this issue, we previously…

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