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This paper introduces a high-throughput software tool framework called {\it sam2bam} that enables users to significantly speedup pre-processing for next-generation sequencing data. The sam2bam is especially efficient on single-node…

基因组学 · 定量生物学 2017-02-08 Takeshi Ogasawara , Yinhe Cheng , Tzy-Hwa Kathy Tzeng

Bloom Filter is a probabilistic membership data structure and it is excessively used data structure for membership query. Bloom Filter becomes the predominant data structure in approximate membership filtering. Bloom Filter extremely…

数据结构与算法 · 计算机科学 2019-04-01 Ripon Patgiri , Sabuzima Nayak , Samir Kumar Borgohain

Database management systems (DBMSs) carefully optimize complex multi-join queries to avoid expensive disk I/O. As servers today feature tens or hundreds of gigabytes of RAM, a significant fraction of many analytic databases becomes…

数据库 · 计算机科学 2015-07-22 Feilong Liu , Spyros Blanas

Motivation: Illumina DNA sequencing is now the predominant source of raw genomic data, and data volumes are growing rapidly. Bioinformatic analysis pipelines are having trouble keeping pace. A common bottleneck in such pipelines is the…

基因组学 · 定量生物学 2014-09-09 Gregory G. Faust , Ira M. Hall

Modern key-value stores rely heavily on Log-Structured Merge (LSM) trees for write optimization, but this design introduces significant read amplification. Auxiliary structures like Bloom filters help, but impose memory costs that scale…

数据结构与算法 · 计算机科学 2025-08-05 Nicholas Fidalgo , Puyuan Ye

Clustering is a fundamental tool in unsupervised learning, used to group objects by distinguishing between similar and dissimilar features of a given data set. One of the most common clustering algorithms is k-means. Unfortunately, when…

机器学习 · 统计学 2021-08-17 Olga Dorabiala , J. Nathan Kutz , Aleksandr Aravkin

The success of deep learning in supervised fine-grained recognition for domain-specific tasks relies heavily on expert annotations. The Open-Set for fine-grained Self-Supervised Learning (SSL) problem aims to enhance performance on…

计算机视觉与模式识别 · 计算机科学 2024-12-24 Prajwal Singh , Gautam Vashishtha , Indra Deep Mastan , Shanmuganathan Raman

In a standard setting of Bayesian optimization (BO), the objective function evaluation is assumed to be highly expensive. Multi-fidelity Bayesian optimization (MFBO) accelerates BO by incorporating lower fidelity observations available with…

In many modern LLM applications, such as retrieval augmented generation, prompts have become programs themselves. In these settings, prompt programs are repeatedly called with different user queries or data instances. A big practical…

计算与语言 · 计算机科学 2024-07-01 Tobias Schnabel , Jennifer Neville

Deep learning for recommendation data is one of the most pervasive and challenging AI workload in recent times. State-of-the-art recommendation models are one of the largest models matching the likes of GPT-3 and Switch Transformer.…

信息检索 · 计算机科学 2022-01-25 Aditya Desai , Li Chou , Anshumali Shrivastava

Filters such as Bloom, quotient, and cuckoo filters are fundamental building blocks providing space-efficient approximate set membership testing. However, many applications need to associate small values with keys-functionality that filters…

数据结构与算法 · 计算机科学 2025-10-08 Michael A. Bender , Alex Conway , Martín Farach-Colton , Rob Johnson , Prashant Pandey

Bloom filters are a fundamental data structure for approximate membership queries, with applications ranging from data analytics to databases and genomics. Several variants have been proposed to accommodate parallel architectures. GPUs,…

分布式、并行与集群计算 · 计算机科学 2025-12-18 Daniel Jünger , Kevin Kristensen , Yunsong Wang , Xiangyao Yu , Bertil Schmidt

Writing concurrent programs for shared memory multiprocessor systems is a nightmare. This hinders users to exploit the full potential of multiprocessors. STM (Software Transactional Memory) is a promising concurrent programming paradigm…

分布式、并行与集群计算 · 计算机科学 2017-07-27 Ajay Singh , Sathya Peri , G Monika , Anila Kumari

Standard Bayesian Optimization (BO) assumes uniform smoothness across the search space an assumption violated in multi-regime problems such as molecular conformation search through distinct energy basins or drug discovery across…

机器学习 · 计算机科学 2026-01-29 Yan Zhang , Xuefeng Liu , Sipeng Chen , Sascha Ranftl , Chong Liu , Shibo Li

Motivation: Building the histogram of occurrences of every $k$-symbol long substring of nucleotide data is a standard step in many bioinformatics applications, known under the name of $k$-mer counting. Its applications include developing de…

数据结构与算法 · 计算机科学 2017-03-03 Sebastian Deorowicz , Marek Kokot , Szymon Grabowski , Agnieszka Debudaj-Grabysz

We show how to answer spatial multiple-set intersection queries in O(n(log w)/w + kt) expected time, where n is the total size of the t sets involved in the query, w is the number of bits in a memory word, k is the output size, and c is any…

数据结构与算法 · 计算机科学 2017-08-31 Michael T. Goodrich

Set queries are fundamental operations in computer systems and applications.This paper addresses the fundamental problem of designing a probabilistic data structure that can quickly process set queries using a small amount of memory. We…

数据结构与算法 · 计算机科学 2016-03-23 Tong Yang , Alex X. Liu , Muhammad Shahzad , Yuankun Zhong , Qiaobin Fu , Zi Li , Gaogang Xie , Xiaoming Li

Restricted Boltzmann Machines (RBMs) are powerful tools for modeling complex systems and extracting insights from data, but their training is hindered by the slow mixing of Markov Chain Monte Carlo (MCMC) processes, especially with highly…

机器学习 · 计算机科学 2025-12-09 Nicolas Béreux , Aurélien Decelle , Cyril Furtlehner , Lorenzo Rosset , Beatriz Seoane

Some transformer attention heads appear to function as membership testers, dedicating themselves to answering the question "has this token appeared before in the context?" We identify these heads across four language models (GPT-2 small,…

机器学习 · 计算机科学 2026-02-20 Peter Balogh

State Machine Replication (SMR) is a fundamental approach to designing service with fault tolerance. However, its requirement for the deterministic execution of transactions often results in single-threaded replicas, which cannot fully…

分布式、并行与集群计算 · 计算机科学 2019-11-27 Gang Wu1 , Guodong Zhao , Yidong Song