相关论文: Numerical evaluation of spray position for improve…
In addition to topical delivery, nasal sprays offer an alternative drug administration route to the systemic circulation, therefore avoiding the need for painful, invasive delivery techniques. Studies on the efficacy of nasal drug delivery…
Improving the efficacy of nasal sprays by enhancing targeted drug delivery to intra-airway tissue sites prone to infection onset is hypothesized to be achievable through an optimization of key device and formulation parameters, such as the…
Efficacy for COVID-19 treatments can be enhanced significantly through targeting the nasopharynx, which has been shown to be the dominant preliminary infection site for SARS-CoV-2. Although intranasal drugs can be administered easily…
Generating anatomically realistic three-dimensional (3D) models of the human sinonasal cavity for numerical investigations of sprayed drug transport presents a host of methodological ambiguities. For example, subject-specific radiographic…
Background: Chronic rhinosinusitis (CRS) is a prevalent and disruptive disease. Medical management including nasal steroid sprays is the primary treatment modality. Computational fluid dynamics (CFD) has been used to characterize sinonasal…
Spray atomization process involves complex multi-phase phenomena. Abundant literature and validation of spray modelling for industrial applications like fuel injection in internal combustion and turbine jet engines are available. However,…
Computational fluid dynamics of the air flow in the human nasal cavities, starting from patient-specific Computer Tomography (CT) scans, is an important tool for diagnostics and surgery planning. However, a complete and systematic…
The study is looking into the potential of using computational fluid dynamics (CFD) as a tool for predicting the outcome of surgery for alleviation of obstructive sleep apnea syndrome (OSAS). From pre- and post-operative computed tomography…
Purpose: Nasal saline irrigation is highly recommended in patients following functional endoscopic sinus surgery (FESS) to aid the postoperative recovery. Post-FESS patients have significantly altered anatomy leading to markedly different…
Numerical simulations and clinical measurements of nasal resistance are in quantitative disagreement. Bias introduced by the design of medical devices has not been considered until now as a possible explanation. The aim of present paper is…
For the one billion sufferers of respiratory disease, managing their disease with inhalers crucially influences their quality of life. Generic treatment plans could be improved with the aid of computational models that account for…
The tracheal flow field shapes particle transport into the lower airways and thus influences both the spread of inhaled pathogens and the effectiveness of aerosol-based therapies. Identifying how different inhalation routes modify the flow…
The application of autonomous robotics to close-contact healthcare tasks has a clear role for the future due to its potential to reduce infection risks to staff and improve clinical efficiency. Nasopharyngeal (NP) swab sample collection for…
This paper proposes a mathematical approach for robust control of a nanoscale drug delivery system in treatment of atherosclerosis. First, a new nonlinear lumped model is introduced for mass transport in the arterial wall, and its accuracy…
A numerical framework for the 'real-time' estimation of the infection risk from airborne diseases (e.g., SARS-CoV-2) in indoor spaces such as hospitals, restaurants, cinemas or teaching rooms is proposed. The developed model is based on the…
The task of learning a diffusion-based neural sampler for drawing samples from an unnormalized target distribution can be viewed as a stochastic optimal control problem on path measures. However, the training of neural samplers can be…
Airflow through the nasal cavity exhibits a wide variety of fluid dynamicsbehaviour due to the intricacy of the nasal geometry. The flow is naturallyunsteady and perhaps turbulent, despite CFD in the literature that assumesa steady laminar…
The acoustic signature of thermal spray processes is known to vary with changes in operating conditions, which also influence particle in-flight velocity and distribution. Building on this idea, the present work first develops an analytical…
Accurate simulations of the flow in the human airway are essential for advancing diagnostic methods. Many existing computational studies rely on simplified geometries or turbulence models, limiting their simulation's ability to resolve flow…
Robot assisted endoluminal intervention is an emerging technique for both benign and malignant luminal lesions. With vision-based navigation, when combined with pre-operative imaging data as priors, it is possible to recover position and…