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The lensless endoscope (LE) is a promising device to acquire in vivo images at a cellular scale. The tiny size of the probe enables a deep exploration of the tissues. Lensless endoscopy with a multicore fiber (MCF) commonly uses a spatial…

Quantitative phase imaging (QPI) is a label-free computational imaging technique used in various fields, including biology and medical research. Modern QPI systems typically rely on digital processing using iterative algorithms for phase…

光学 · 物理学 2023-06-28 Yuhang Li , Yi Luo , Deniz Mengu , Bijie Bai , Aydogan Ozcan

Accurate computational ptychographic phase reconstructions are enabled by fast direct-electron cameras with high dynamic ranges used for four-dimensional scanning transmission electron microscopy (4D-STEM). The availability of open software…

材料科学 · 物理学 2025-05-01 Toma Susi

Ptychography is an imaging technique that captures multiple overlapping snapshots of a sample, illuminated coherently by a moving localized probe. The image recovery from ptychographic data is generally achieved via an iterative algorithm…

图像与视频处理 · 电气工程与系统科学 2025-10-06 Weijie Gan , Qiuchen Zhai , Michael Thompson McCann , Cristina Garcia Cardona , Ulugbek S. Kamilov , Brendt Wohlberg

Electron ptychography describes a family of algorithms which are used to enable the reconstruction of complex specimen transmission functions of a sample in order to obtain both phase and amplitude information, as applied within the realms…

光学 · 物理学 2025-03-17 L. Clark , P. D. Nellist

In Fourier ptychography, multiple low resolution images are captured and subsequently combined computationally into a high-resolution, large-field of view micrograph. A theoretical image-formation model based on the assumption of plane-wave…

光学 · 物理学 2022-06-22 Tomas Aidukas , Lars Loetgering , Andrew Robert Harvey

Fourier ptychographic microscopy enables gigapixel-scale imaging, with both large field-of-view and high resolution. Using a set of low-resolution images that are recorded under varying illumination angles, the goal is to computationally…

信号处理 · 电气工程与系统科学 2018-03-13 Emrah Bostan , Mahdi Soltanolkotabi , David Ren , Laura Waller

Positron Emission Tomography (PET) is a vital imaging modality widely used in clinical diagnosis and preclinical research but faces limitations in image resolution and signal-to-noise ratio due to inherent physical degradation factors.…

图像与视频处理 · 电气工程与系统科学 2024-11-11 Boxiao Yu , Kuang Gong

Ultrasound molecular imaging (UMI) is an advanced imaging modality that shows promise in detecting cancer at early stages. It uses microbubbles as contrast agents, which are functionalized to bind to cancer biomarkers overexpressed on…

Single-molecule microscopy has become an indispensable tool for biochemical analysis. The capability of characterizing distinct properties of individual molecules without averaging has provided us with a different perspective for the…

应用物理 · 物理学 2020-05-21 Miao-Hsuan Chien , Silvan Schmid

Label-Free Multiphoton Microscopy is a very powerful optical microscopy that can be applied to study samples with no need for exogenous fluorescent probes, keeping the main benefits of a Multiphoton approach, like longer penetration depths…

Studying the growth and metabolism of microbes provides critical insights into their evolutionary adaptations to harsh environments, which are essential for microbial research and biotechnology applications. In this study, we developed an…

图像与视频处理 · 电气工程与系统科学 2025-05-06 Shuang Zhang , Carleton Coffin , Karyn L. Rogers , Catherine Ann Royer , Ge Wang

Label-free imaging has gained broad interest because of its potential to omit elaborate staining procedures which is especially relevant for in vivo use. Label-free multiphoton microscopy (MPM), for instance, exploits two-photon excitation…

Monocular depth estimation (MDE) aims to infer per-pixel depth from a single RGB image. While diffusion models have advanced MDE with impressive generalization, they often exhibit limitations in accurately reconstructing far-range regions.…

计算机视觉与模式识别 · 计算机科学 2025-11-18 Mingxia Zhan , Li Zhang , Yingjie Wang , Xiaomeng Chu , Beibei Wang , Yanyong Zhang

Despite fluorescent cell-labelling being widely employed in biomedical studies, some of its drawbacks are inevitable, with unsuitable fluorescent probes or probes inducing a functional change being the main limitations. Consequently, the…

Nonlinear microscopy has evolved over the last few decades to become a powerful tool for imaging and spectroscopic applications in biological sciences. In this study, I$^2$PIE, a novel spectral phase control technique, was implemented in…

The ability to resolve and quantify features at submicrometer scales from a single-shot image is crucial for real-time uncovering intricate structures in unlabeled biological samples and analyzing them at the subcellular level. We introduce…

光学 · 物理学 2025-01-22 Jaromír Běhal , Miroslav Ježek

Correlative microscopy is a powerful technique that combines the advantages of multiple imaging modalities to achieve a comprehensive understanding of investigated samples. For example, fluorescence microscopy provides unique functional…

Pulse-shape discrimination (PSD) in high-purity germanium (HPGe) detectors is central to rare-event searches such as neutrinoless double-beta decay (0vBB), yet conventional approaches compress each waveform into a small set of summary…

高能物理 - 实验 · 物理学 2026-03-09 Marta Babicz , Saúl Alonso-Monsalve , Alain Fauquex , Laura Baudis

Fourier Ptychography is a recently proposed imaging technique that yields high-resolution images by computationally transcending the diffraction blur of an optical system. At the crux of this method is the phase retrieval algorithm, which…

计算机视觉与模式识别 · 计算机科学 2018-05-10 Lokesh Boominathan , Mayug Maniparambil , Honey Gupta , Rahul Baburajan , Kaushik Mitra
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