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The article proposes a conceptual approach for evaluating the impact of engineered nanoparticles (NPs) on the functionality of small biomolecules. The developed machine learning (ML) model is based on in-silico 13C NMR spectroscopy chemical…

其他定量生物学 · 定量生物学 2026-03-23 Mariya L Ivanova , Michael Nichols , Nicola Russo , Gueorgui Mihaylov , Konstantin Nikolic

Accurate fetal birth weight prediction is a cornerstone of prenatal care, yet traditional methods often rely on imaging technologies that remain inaccessible in resource-limited settings. This study presents a novel machine learning-based…

We consider nonparametric prediction with multiple covariates, in particular categorical or functional predictors, or a mixture of both. The method proposed bases on an extension of the Nadaraya-Watson estimator where a kernel function is…

统计方法学 · 统计学 2022-08-05 Leonie Selk , Jan Gertheiss

We propose a methodology for testing linear hypothesis in high-dimensional linear models. The proposed test does not impose any restriction on the size of the model, i.e. model sparsity or the loading vector representing the hypothesis.…

统计方法学 · 统计学 2019-07-09 Yinchu Zhu , Jelena Bradic

The persistent battle to decrease childhood mortality serves as a commonly employed benchmark for gauging advancements in the field of medicine. Globally, the under-5 mortality rate stands at approximately 5 million, with a significant…

机器学习 · 计算机科学 2023-11-21 Binod Regmi , Chiranjibi Shah

This paper introduces an approach for detecting differences in the first-order structures of spatial point patterns. The proposed approach leverages the kernel mean embedding in a novel way by introducing its approximate version tailored to…

统计方法学 · 统计学 2020-06-15 Raif M. Rustamov , James T. Klosowski

This paper deals with the nonparametric density estimation of the regression error term assuming its independence with the covariate. The difference between the feasible estimator which uses the estimated residuals and the unfeasible one…

统计理论 · 数学 2010-10-05 Rawane Samb

In this work, we develop and study an empirical projection operator scheme for solving nonparametric regression problems. This scheme is based on an approximate projection of the regression function over a suitable reproducing kernel…

统计理论 · 数学 2020-02-04 Bilel Bousselmi , Jean-François Dupuy , Abderrazek Karoui

We introduce a low dimensional function of the site frequency spectrum that is tailor-made for distinguishing coalescent models with multiple mergers from Kingman coalescent models with population growth, and use this function to construct…

种群与进化 · 定量生物学 2019-08-13 Jere Koskela

The two-sample hypothesis testing problem is studied for the challenging scenario of high dimensional data sets with small sample sizes. We show that the two-sample hypothesis testing problem can be posed as a one-class set classification…

机器学习 · 统计学 2017-11-15 Hamed Masnadi-Shirazi

Single-cell technologies offer insights into molecular feature distributions, but comparing them poses challenges. We propose a kernel-testing framework for non-linear cell-wise distribution comparison, analyzing gene expression and…

Penalized empirical risk minimization with a surrogate loss function is often used to learn a high-dimensional linear decision rule in classification problems. Although much of the literature focus on the generalization error, there is a…

统计方法学 · 统计学 2026-05-06 Muxuan Liang , Yang Ning , Maureen A Smith , Ying-Qi Zhao

Kernel ridge regression (KRR) is a foundational tool in machine learning, with recent work emphasizing its connections to neural networks. However, existing theory primarily addresses the i.i.d. setting, while real-world data often exhibits…

机器学习 · 统计学 2025-10-20 Dechen Zhang , Zhenmei Shi , Yi Zhang , Yingyu Liang , Difan Zou

We propose a kernel-based nonparametric estimator for the causal effect when the cause is corrupted by error. We do so by generalizing estimation in the instrumental variable setting. Despite significant work on regression with measurement…

机器学习 · 计算机科学 2022-06-22 Yuchen Zhu , Limor Gultchin , Arthur Gretton , Matt Kusner , Ricardo Silva

Childhood obesity remains a major public health challenge in the United States, strongly influenced by a combination of individual-level, household-level, and environmental-level risk factors. Traditional epidemiological studies typically…

机器学习 · 计算机科学 2025-12-30 Eswarasanthosh Kumar Mamillapalli , Nishtha Sharma

Kernel-based tests provide a simple yet effective framework that use the theory of reproducing kernel Hilbert spaces to design non-parametric testing procedures. In this paper we propose new theoretical tools that can be used to study the…

统计理论 · 数学 2022-09-02 Tamara Fernández , Nicolás Rivera

A framework for estimation and hypothesis testing of functional restrictions against general alternatives is proposed. The parameter space is a reproducing kernel Hilbert space (RKHS). The null hypothesis does not necessarily define a…

统计方法学 · 统计学 2018-08-21 Alessio Sancetta

Nonparametric density estimation for compositional data supported on the simplex is examined under a missing at random mechanism. Rather than imputing missing values and estimating the density from a completed data set, we adopt a strategy…

统计方法学 · 统计学 2026-03-10 Hanen Daayeb , Wissem Jedidi , Salah Khardani , Guanjie Lyu , Frédéric Ouimet

This paper carries out a large dimensional analysis of a variation of kernel ridge regression that we call \emph{centered kernel ridge regression} (CKRR), also known in the literature as kernel ridge regression with offset. This modified…

We consider the problem of high-dimensional non-linear variable selection for supervised learning. Our approach is based on performing linear selection among exponentially many appropriately defined positive definite kernels that…

机器学习 · 计算机科学 2009-09-08 Francis Bach