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This paper presents a reproducible and process-aware pipeline for predictive monitoring of clinical pathways. The approach integrates data lifting, temporal reconstruction, event log construction, prefix-based representations, and…

机器学习 · 计算机科学 2026-05-13 Pasquale Ardimento , Mario Luca Bernardi , Marta Cimitile , Samuele Latorre

Waveform signal analysis is a complex and important task in medical care. For example, mechanical ventilators are critical life-support machines, but they can cause serious injury to patients if they are out of synchronization with the…

计算工程、金融与科学 · 计算机科学 2025-01-24 Wenjie Xu , Scott Dick

Electrocardiogram (ECG) acquisition requires an automated system and analysis pipeline for understanding specific rhythm irregularities. Deep neural networks have become a popular technique for tracing ECG signals, outperforming human…

This article presents a novel method for predicting suicidal ideation from Electronic Health Records (EHR) and Ecological Momentary Assessment (EMA) data using deep sequential models. Both EHR longitudinal data and EMA question forms are…

Idiopathic ventricular arrhythmia (IVAs) is extra abnormal heartbeats disturbing the regular heart rhythm that can become fatal if left untreated. Cardiac catheter ablation is the standard approach to treat IVAs, however, a crucial…

信号处理 · 电气工程与系统科学 2023-02-22 Mohammadreza Shahsavari , Niloufar Delfan , Mohamad Forouzanfar

In stepped wedge cluster randomized trials (SW-CRTs), observations collected under the control condition are, on average, from an earlier time than observations collected under the intervention condition. In a cohort design, participants…

统计方法学 · 统计学 2023-02-23 Jale Basten , Katja Ickstadt , Nina Timmesfeld

Long-term adherence to medication is a critical factor in preventing chronic diseases, such as cardiovascular disease. To address poor adherence, physicians may recommend adherence-improving interventions; however, such interventions are…

最优化与控制 · 数学 2026-02-24 Daniel Otero-Leon , Mariel Lavieri , Brian Denton , Jeremy Sussman , Rodney Hayward

Acute kidney injury (AKI) is a common and serious complication after a surgery which is associated with morbidity and mortality. The majority of existing perioperative AKI risk score prediction models are limited in their generalizability…

Structural heart disease (SHD) is a prevalent condition with many undiagnosed cases, and early detection is often limited by the high cost and accessibility constraints of echocardiography (ECHO). Recent studies show that artificial…

应用统计 · 统计学 2026-03-04 Ya Zhou , Zhaohong Sun , Tianxiang Hao , Xiangjie Li

This paper develops a nonparametric model that represents how sequences of outcomes and treatment choices influence one another in a dynamic manner. In this setting, we are interested in identifying the average outcome for individuals in…

计量经济学 · 经济学 2019-01-16 Sukjin Han

Composite endpoints that combine recurrent non-fatal events with a terminal event are increasingly used in randomized clinical trials, yet conventional time-to-first event analyses may obscure clinically relevant information. We compared…

统计方法学 · 统计学 2025-12-16 Adrien Orué , Derek Dinart , Laurent Billot , Carine Bellera , Virginie Rondeau

Objective: To introduce a method for tracking results and utilization of Artificial Intelligence (tru-AI) in radiology. By tracking both large-scale utilization and AI results data, the tru-AI approach is designed to calculate surrogates…

定量方法 · 定量生物学 2020-10-16 Axel Wismüller , Larry Stockmaster

Despite numerous studies on cerebral arterial blood flow, there has not yet been a comprehensive description of hemodynamics in patients undergoing debranching thoracic endovascular aortic repair (dTEVAR), a promising surgical option for…

Alzheimer's Disease (AD) research has shifted to focus on biomarker trajectories and their potential use in understanding the underlying AD-related pathological process. A conceptual framework was proposed in modern AD research that…

应用统计 · 统计学 2024-09-12 Zhuojun Tang , Yuxin Zhu , Kexin Zhang , Zheyu Wang

The accurate quantification of left ventricular (LV) deformation/strain shows significant promise for quantitatively assessing cardiac function for use in diagnosis and therapy planning (Jasaityte et al., 2013). However, accurate estimation…

Heart failure (HF) contributes to circa 200,000 annual hospitalizations in France. With the increasing age of HF patients, elucidating the specific causes of inpatient mortality became a public health problematic. We introduce a novel…

Background: Multiple medical and non-medical stressors, along with the complicity of their exposure pathways, have posted significant challenges to the epidemiological interpretation of the non-communicable diseases, including…

应用统计 · 统计学 2025-03-07 Jiangling Liu , Ya Liu , Banyun Zheng , Longjian Liu , Heqing Shen

Early prediction of Alzheimer's disease (AD) is crucial for timely intervention and treatment. This study aims to use machine learning approaches to analyze longitudinal electronic health records (EHRs) of patients with AD and identify…

Hypoplastic left heart syndrome (HLHS) is characterized by severe underdevelopment of left ventricle requiring staged surgical reconstruction (stages) to allow the right ventricle (RV) alone to support the circulation. In this setting…

Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia, and its clinical assessment requires accurate characterization of atrial electrical activity. Noninvasive electrocardiographic imaging (ECGI) combined with deep…

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