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Foreseeing the brain evolution as a complex highly inter-connected system, widely modeled as a graph, is crucial for mapping dynamic interactions between different anatomical regions of interest (ROIs) in health and disease. Interestingly,…

图像与视频处理 · 电气工程与系统科学 2020-09-24 Zeynep Gurler , Ahmed Nebli , Islem Rekik

The human brain can be conceptualized as a dynamical system. Utilizing resting state fMRI time series imaging, we can study the underlying dynamics at ear-marked Regions of Interest (ROIs) to understand structure or lack thereof. This…

计算机视觉与模式识别 · 计算机科学 2023-12-01 Ninad Aithal , Chakka Sai Pradeep , Neelam Sinha

Autism Spectrum Disorder (ASD) is a complicated neurological condition which is challenging to diagnose. Numerous studies demonstrate that children diagnosed with autism struggle with maintaining attention spans and have less focused…

Brain network analysis provides an interpretable framework for characterizing brain organization and has been widely used for neurological disorder identification. Recent advances in self-supervised learning have motivated the development…

计算机视觉与模式识别 · 计算机科学 2026-03-24 Jiaxing Xu , Jingying Ma , Xin Lin , Yuxiao Liu , Kai He , Qika Lin , Yiping Ke , Yang Li , Dinggang Shen , Mengling Feng

Alzheimer's disease progression prediction is critical for patients with early Mild Cognitive Impairment (MCI) to enable timely intervention and improve their quality of life. While existing progression prediction techniques demonstrate…

计算机视觉与模式识别 · 计算机科学 2025-11-18 Zhongying Deng , Shujun Wang , Angelica I Aviles-Rivero , Zoe Kourtzi , Carola-Bibiane Schönlieb

Several brain disorders can be detected by observing alterations in the brain's structural and functional connectivities. Neurological findings suggest that early diagnosis of brain disorders, such as mild cognitive impairment (MCI), can…

神经元与认知 · 定量生物学 2021-10-22 Alpay Tekin , Ahmed Nebli , Islem Rekik

Arguably, unsupervised learning plays a crucial role in the majority of algorithms for processing brain imaging. A recently introduced unsupervised approach Deep InfoMax (DIM) is a promising tool for exploring brain structure in a flexible…

机器学习 · 计算机科学 2019-05-02 Alex Fedorov , R Devon Hjelm , Anees Abrol , Zening Fu , Yuhui Du , Sergey Plis , Vince D. Calhoun

Brightfield and fluorescent imaging of whole brain sections are funda- mental tools of research in mouse brain study. As sectioning and imaging become more efficient, there is an increasing need to automate the post-processing of sec- tions…

计算机视觉与模式识别 · 计算机科学 2018-03-12 Yuncong Chen , David Kleinfeld , Martyn Goulding , Yoav Freund

Whole-slide image classification represents a key challenge in computational pathology and medicine. Attention-based multiple instance learning (MIL) has emerged as an effective approach for this problem. However, the effect of attention…

Prior work using Masked Autoencoders (MAEs) typically relies on random patch masking based on the assumption that images have significant redundancies across different channels, allowing for the reconstruction of masked content using…

计算机视觉与模式识别 · 计算机科学 2025-10-28 Chau Pham , Juan C. Caicedo , Bryan A. Plummer

Predicting the risk of clinical progression from cognitively normal (CN) status to mild cognitive impairment (MCI) or Alzheimer's disease (AD) is critical for early intervention in Alzheimer's disease (AD). Traditional survival models often…

应用统计 · 统计学 2025-03-24 Dhrubajyoti Ghosh , Samhita Pal , Michael Lutz , Sheng Luo

Alzheimer's Disease (AD) is a progressive neurodegenerative disease. Amnestic mild cognitive impairment (MCI) is a common first symptom before the conversion to clinical impairment where the individual becomes unable to perform activities…

计算机视觉与模式识别 · 计算机科学 2017-10-16 Donghuan Lu , Karteek Popuri , Weiguang Ding , Rakesh Balachandar , Mirza Faisal Beg

In the context of electroencephalogram (EEG)-based driver drowsiness recognition, it is still challenging to design a calibration-free system, since EEG signals vary significantly among different subjects and recording sessions. Many…

信号处理 · 电气工程与系统科学 2022-02-21 Jian Cui , Zirui Lan , Olga Sourina , Wolfgang Müller-Wittig

Current multi-instance learning algorithms for pathology image analysis often require a substantial number of Whole Slide Images for effective training but exhibit suboptimal performance in scenarios with limited learning data. In clinical…

计算机视觉与模式识别 · 计算机科学 2024-07-16 Linhao Qu , Dingkang Yang , Dan Huang , Qinhao Guo , Rongkui Luo , Shaoting Zhang , Xiaosong Wang

This paper explores deterioration in Alzheimers Disease using Machine Learning. Subjects were split into two datasets based on baseline diagnosis (Cognitively Normal, Mild Cognitive Impairment), with outcome of deterioration at final visit…

机器学习 · 计算机科学 2023-06-21 Henry Musto , Daniel Stamate , Ida Pu , Daniel Stahl

Alzheimer's disease is a progressive neurodegenerative disorder in which mild cognitive impairment (MCI) marks a critical transition between aging and dementia. Neuroimaging modalities, such as structural MRI, provide biomarkers of this…

机器学习 · 计算机科学 2026-03-02 Vrushank Ahire , Yogesh Kumar , Anouck Girard , M. A. Ganaie

Introduction: It is challenging at baseline to predict when and which individuals who meet criteria for mild cognitive impairment (MCI) will ultimately progress to Alzheimer's disease (AD) dementia. Methods: A deep learning method is…

计算机视觉与模式识别 · 计算机科学 2019-04-17 Hongming Li , Mohamad Habes , David A. Wolk , Yong Fan

Deep learning implemented with convolutional network architectures can exceed specialists' diagnostic accuracy. However, whole-image deep learning trained on a given dataset may not generalize to other datasets. The problem arises because…

计算机视觉与模式识别 · 计算机科学 2023-05-17 Norsang Lama , R. Joe Stanley , Anand Nambisan , Akanksha Maurya , Jason Hagerty , William V. Stoecker

The brain-computer interface (BCI) establishes a non-muscle channel that enables direct communication between the human body and an external device. Electroencephalography (EEG) is a popular non-invasive technique for recording brain…

机器学习 · 计算机科学 2026-02-23 Jamal Hwaidi , Mohamed Chahine Ghanem

Whole-slide image (WSI) preprocessing, comprising tissue detection followed by patch extraction, is foundational to AI-driven computational pathology but remains a major bottleneck for scaling to large and heterogeneous cohorts. We present…