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Structural and functional heterogeneity are hallmarks of cortical circuits, from broad degree distributions in the mouse connectome to diverse intrinsic neuronal timescales. Yet a mechanistic link between connectivity heterogeneity and…

神经元与认知 · 定量生物学 2026-03-05 Marco Zenari , Luca Taffarello , Luca Mazzucato , Amos Maritan , Samir Suweis

Mapping of human brain structural connectomes via diffusion MRI offers a unique opportunity to understand brain structural connectivity and relate it to various human traits, such as cognition. However, head displacement during image…

神经元与认知 · 定量生物学 2024-09-13 Yizi Zhang , Meimei Liu , Zhengwu Zhang , David Dunson

Clinical studies reveal disruptions in brain structural connectivity (SC) and functional connectivity (FC) in neuropsychiatric disorders such as schizophrenia (SZ). Traditional approaches might rely solely on SC due to limited functional…

图像与视频处理 · 电气工程与系统科学 2026-01-27 Badhan Mazumder , Ayush Kanyal , Lei Wu , Vince D. Calhoun , Dong Hye Ye

We propose a data-driven approach to represent neuronal network dynamics as a Probabilistic Graphical Model (PGM). Our approach learns the PGM structure by employing dimension reduction to network response dynamics evoked by stimuli applied…

神经元与认知 · 定量生物学 2017-11-02 Hexuan Liu , Jimin Kim , Eli Shlizerman

In recent years, there has been strong interest in neuroscience studies to investigate brain organization through networks of brain regions that demonstrate strong functional connectivity (FC). These networks are extracted from observed…

应用统计 · 统计学 2017-03-14 Phebe Brenne Kemmer , F. DuBois Bowman , Helen Mayberg , Ying Guo

Although modern imaging technologies allow us to study connectivity between two distinct brain regions in-vivo, an in-depth understanding of how anatomical structure supports brain function and how spontaneous functional fluctuations emerge…

神经元与认知 · 定量生物学 2024-10-29 Ziquan Wei , Tingting Dan , Jiaqi Ding , Guorong Wu

While most models of randomly connected networks assume nodes with simple dynamics, nodes in realistic highly connected networks, such as neurons in the brain, exhibit intrinsic dynamics over multiple timescales. We analyze how the…

无序系统与神经网络 · 物理学 2019-09-11 Samuel P. Muscinelli , Wulfram Gerstner , Tilo Schwalger

Resting-state functional magnetic resonance imaging (rs-fMRI) is a noninvasive technique pivotal for understanding human neural mechanisms of intricate cognitive processes. Most rs-fMRI studies compute a single static functional…

Functional connectivity (FC) studies have demonstrated the overarching value of studying the brain and its disorders through the undirected weighted graph of fMRI correlation matrix. Most of the work with the FC, however, depends on the way…

神经元与认知 · 定量生物学 2021-12-09 Usman Mahmood , Zening Fu , Vince Calhoun , Sergey Plis

Modelling the dynamics of interactions in a neuronal ensemble is an important problem in functional connectivity research. One popular framework is latent factor models (LFMs), which have achieved notable success in decoding neuronal…

统计方法学 · 统计学 2023-05-18 Meixi Chen , Martin Lysy , David Moorman , Reza Ramezan

Spike timing dependent plasticity (STDP) is believed to play an important role in shaping the structure of neural circuits. Here we show that STDP generates effective interactions between synapses of different neurons, which were neglected…

神经元与认知 · 定量生物学 2016-08-25 Neta Ravid Tannenbaum , Yoram Burak

Functional connectivity is a key approach to investigate oscillatory activities of the brain that provides important insights on the underlying dynamic of neuronal interactions and that is mostly applied for brain activity analysis.…

神经元与认知 · 定量生物学 2022-02-17 Marie-Constance Corsi , Sylvain Chevallier , Fabrizio De Vico Fallani , Florian Yger

One of the most central questions in network science is: which nodes are most important? Often this question is answered using structural properties such as high connectedness or centrality in the network. However, static structural…

物理与社会 · 物理学 2021-07-02 Casper van Elteren , Rick Quax , Peter Sloot

One major challenge in neuroscience is the identification of interrelations between signals reflecting neural activity and how information processing occurs in the neural circuits. At the cellular and molecular level, mechanisms of signal…

应用统计 · 统计学 2019-09-27 Giacomo Aletti , Davide Lonardoni , Giovanni Naldi , Thierry Nieus

Several approaches to cognition and intelligence research rely on statistics-based models testing, namely factor analysis. In the present work we exploit the emerging dynamical systems perspective putting the focus on the role of the…

物理与社会 · 物理学 2018-03-15 Gemma Rosell-Tarragó , Emanuele Cozzo , Albert Díaz-Guilera

This paper addresses the question of the brain's critical dynamics after an injury such as a stroke. It is hypothesized that the healthy brain operates near a phase transition (critical point), which provides optimal conditions for…

神经元与认知 · 定量生物学 2023-08-01 Jakub Janarek , Zbigniew Drogosz , Jacek Grela , Jeremi K. Ochab , Paweł Oświęcimka

Human learning is a complex phenomenon requiring flexibility to adapt existing brain function and precision in selecting new neurophysiological activities to drive desired behavior. These two attributes -- flexibility and selection -- must…

神经元与认知 · 定量生物学 2013-06-28 Danielle S. Bassett , Nicholas F. Wymbs , Mason A. Porter , Peter J. Mucha , Jean M. Carlson , Scott T. Grafton

Rich, spontaneous brain activity has been observed across a range of different temporal and spatial scales. These dynamics are thought to be important t for efficient neural functioning. Experimental evidence suggests that these neural…

神经元与认知 · 定量生物学 2015-01-21 Peter J. Hellyer , Barbara Jachs , Robert Leech , Claudia Clopath

Resting-state functional magnetic resonance imaging (rs-fMRI), which measures the spontaneous fluctuations in the blood oxygen level-dependent (BOLD) signal, is increasingly utilized for the investigation of the brain's physiological and…

Recent studies have been using graph theoretical approaches to model complex networks (such as social, infrastructural or biological networks), and how their hardwired circuitry relates to their dynamic evolution in time. Understanding how…

神经元与认知 · 定量生物学 2015-07-17 Anca Radulescu
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