相关论文: Perfusion and apparent oxygenation in the human pl…
Purpose: A combined diffusion-relaxometry MR acquisition and analysis pipeline for in-vivo human placenta, which allows for exploration of coupling between T2* and apparent diffusion coefficient (ADC) measurements in a sub 10 minute scan…
We propose an analytical approach to solving the diffusion-convection equations governing oxygen transport in the human placenta. We show that only two geometrical characteristics of a placental cross-section, villi density and the…
Objective(s): T$_2$* and susceptibility ($\chi$) MRI mapping provide complimentary measures of the haemodynamic environment in the placenta. The aims of this work were to use these simultaneously obtained measures to investigate the role of…
Diffuse optics has the potential to offer a substantial advancement in fetal health monitoring via enabling continuous measurement of fetal blood oxygen saturation (fSpO$_2$). Aiming to enhance the sensing accuracy and to elucidate the…
During pregnancy, oxygen diffuses from maternal to fetal blood through villous trees in the placenta. In this paper, we simulate blood flow and oxygen transfer in feto-placental capillaries by converting three-dimensional representations of…
Purpose: Ultrasound is the most commonly used medical imaging modality for diagnosis and screening in clinical practice. Due to its safety profile, noninvasive nature and portability, ultrasound is the primary imaging modality for fetal…
In 2020 we first described placental contractions, and we have now undertaken a study to characterise them and seek features that might automatically separate them from uterine contractions. We recruited 36 healthy pregnant women to undergo…
We present a stream-tube model of oxygen exchange inside a human placenta functional unit (a placentone). The effect of villi density on oxygen transfer efficiency is assessed by numerically solving the diffusion-convection equation in a…
Fetal oxygen delivery and consumption and blood gases in relation to gestational age. Oxygen crosses the placenta by diffusion and placental permeability to O$_2$ is high. Thus, the fetus receives adequate amounts, but vascular Po$_2$ is…
Fetal growth restriction (FGR) is a prevalent pregnancy condition characterised by failure of the fetus to reach its genetically predetermined growth potential. We explore the application of model fitting techniques, linear regression…
A clinical case study of high-intensity focused ultrasound (HIFU) treatment in the uterine fibroid was conducted. During the therapy, poor heating efficacy was observed which could be attributed to several factors such as the local…
The quality of fetal MRI is significantly affected by unpredictable and substantial fetal motion, leading to the introduction of artifacts even when fast acquisition sequences are employed. The development of 3D real-time fetal pose…
Accurate assessment of tissue perfusion is crucial in visceral surgery, especially during anastomosis. Currently, subjective visual judgment is commonly employed in clinical settings. Hyperspectral imaging (HSI) offers a non-invasive,…
Perfusion analysis computes blood flow parameters (blood volume, blood flow, mean transit time) from the observed flow of contrast agent, passing through the patient's vascular system. Perfusion deconvolution has been widely accepted as the…
Fluid-structure interaction (FSI) modeling, a technique widely used to enhance imaging modalities for adult and pediatric heart diseases, has been underutilized in the context of fetal circulation because of limited data on flow conditions…
Perfusion imaging (PI) is clinically used to assess strokes and brain tumors. Commonly used PI approaches based on magnetic resonance imaging (MRI) or computed tomography (CT) measure the effect of a contrast agent moving through blood…
Accurate placental segmentation is essential for quantitative analysis of the placenta. However, this task is particularly challenging in T2*-weighted placental imaging due to: (1) weak and inconsistent boundary contrast across individual…
Fetal Magnetic Resonance Imaging at low field strengths is emerging as an exciting direction in perinatal health. Clinical low field (0.55T) scanners are beneficial for fetal imaging due to their reduced susceptibility-induced artefacts,…
Accurate spatial correspondence between medical images is essential for longitudinal analysis, lesion tracking, and image-guided interventions. Medical image registration methods rely on local intensity-based similarity measures, which fail…
Purpose: To provide real-time quantitative organ-specific information - specifically placental and brain T2* - to allow optimization of the MR examination to the individual patient. Methods: A FIRE-based real-time setup segmenting placenta…