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Alzheimer's disease (AD) is an irreversible and progressive brain disease that can be stopped or slowed down with medical treatment. Language changes serve as a sign that a patient's cognitive functions have been impacted, potentially…

计算与语言 · 计算机科学 2018-04-19 Sweta Karlekar , Tong Niu , Mohit Bansal

Sepsis-induced acute respiratory failure (ARF) is a serious complication with a poor prognosis. This paper presents a deep representation learningbased phenotyping method to identify distinct groups of clinical trajectories of septic…

信号处理 · 电气工程与系统科学 2024-05-07 Alan Wu , Tilendra Choudhary , Pulakesh Upadhyaya , Ayman Ali , Philip Yang , Rishikesan Kamaleswaran

Alzheimer's disease (AD) is the most common neurodegenerative disease in older people. Despite considerable efforts to find a cure for AD, there is a 99.6% failure rate of clinical trials for AD drugs, likely because AD patients cannot…

机器学习 · 计算机科学 2019-03-25 Jack Albright

The study's objective is to explore the distinctions in the functional brain network connectivity between Alzheimer's Disease (AD) patients and normal controls using Functional Magnetic Resonance Imaging (fMRI). The study included 590…

神经元与认知 · 定量生物学 2023-05-17 Yongcheng Yao

Genome-wide association studies (GWAS) offer new opportunities to identify genetic risk factors for Alzheimer's disease (AD). Recently, collaborative efforts across different institutions emerged that enhance the power of many existing…

Alzheimer's disease (AD) is characterized by complex and largely unknown progression dynamics affecting the brain's morphology. Although the disease evolution spans decades, to date we cannot rely on long-term data to model the pathological…

应用统计 · 统计学 2019-08-14 Clement Abi Nader , Nicholas Ayache , Philippe Robert , Marco Lorenzi

Alzheimer's disease (AD) has a complex and multifactorial etiology, which requires integrating information about neuroanatomy, genetics, and cerebrospinal fluid biomarkers for accurate diagnosis. Hence, recent deep learning approaches…

机器学习 · 计算机科学 2023-03-15 Tom Nuno Wolf , Sebastian Pölsterl , Christian Wachinger

Alzheimer's disease (AD) is a neuro-degenerative disease that can cause dementia and result severe reduction in brain function inhibiting simple tasks especially if no preventative care is taken. Over 1 in 9 Americans suffer from AD induced…

图像与视频处理 · 电气工程与系统科学 2023-06-21 Paul K. Mandal , Rakesh Mahto

Introspection of deep supervised predictive models trained on functional and structural brain imaging may uncover novel markers of Alzheimer's disease (AD). However, supervised training is prone to learning from spurious features (shortcut…

Multimodal neuroimage can provide complementary information about the dementia, but small size of complete multimodal data limits the ability in representation learning. Moreover, the data distribution inconsistency from different…

计算机视觉与模式识别 · 计算机科学 2021-07-22 Qiankun Zuo , Baiying Lei , Yanyan Shen , Yong Liu , Zhiguang Feng , Shuqiang Wang

Dementia is a syndrome characterised by the decline of different cognitive abilities. Alzheimer's Disease (AD) is the most common dementia affecting cognitive domains such as memory and learning, perceptual-motion or executive function.…

计算机视觉与模式识别 · 计算机科学 2018-10-26 Juan Manuel Fernández Montenegro

Early diagnosis of Alzheimer Diagnostics (AD) is a challenging task due to its subtle and complex clinical symptoms. Deep learning-assisted medical diagnosis using image recognition techniques has become an important research topic in this…

图像与视频处理 · 电气工程与系统科学 2024-01-26 Yihao Lin , Ximeng Li , Yan Zhang , Jinshan Tang

Studying the relationship between neuroanatomy and cognitive decline due to Alzheimer's has been a major research focus in the last decade. However, to infer cause-effect relationships rather than simple associations from observational…

统计方法学 · 统计学 2021-06-22 Sebastian Pölsterl , Christian Wachinger

Epilepsy, affecting approximately 50 million people globally, is characterized by abnormal brain activity and remains challenging to treat. The diagnosis of epilepsy relies heavily on electroencephalogram (EEG) data, where specialists…

We present two multimodal fusion-based deep learning models that consume ASR transcribed speech and acoustic data simultaneously to classify whether a speaker in a structured diagnostic task has Alzheimer's Disease and to what degree,…

计算与语言 · 计算机科学 2021-07-01 Morteza Rohanian , Julian Hough , Matthew Purver

Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia in the elderly. The extracellular accumulation of amyloid-$\beta$ (A$\beta$) in senile plaques is a principal event in the pathogenesis and there…

医学物理 · 物理学 2018-03-12 E. G. Lobanova , S. V. Lobanov , K. Triantafilou , W. Langbein , P. Borri

Alzheimer's disease (AD) and Lewy body dementia (LBD) present overlapping clinical features yet require distinct diagnostic strategies. While neuroimaging-based brain network analysis is promising, atlas-based representations may obscure…

神经元与认知 · 定量生物学 2026-02-25 Minheng Chen , Tong Chen , Chao Cao , Jing Zhang , Tianming Liu , Li Su , Dajiang Zhu

Background. Alzheimer's disease and related dementia (ADRD) are characterized by multiple and progressive anatomo clinical changes. Yet, modeling changes over disease course from cohort data is challenging as the usual timescales are…

统计方法学 · 统计学 2024-07-17 Jérémie Lespinasse , Carole Dufouil , Cécile Proust-Lima , the MEMENTO study group

Alzheimer's disease (AD) persists as a paramount challenge in neurological research, characterized by the pathological hallmarks of amyloid-beta (Abeta) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. This review…

神经元与认知 · 定量生物学 2025-12-15 Xutong She

Alzheimer's disease (AD) is a prevalent and debilitating neurodegenerative disorder impacting a large aging population. Detecting AD in all its presymptomatic and symptomatic stages is crucial for early intervention and treatment. An active…

计算机视觉与模式识别 · 计算机科学 2023-10-31 Yasmine Mustafa , Tie Luo