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Protein mutations can have profound effects on biological function, making accurate prediction of property changes critical for drug discovery, protein engineering, and precision medicine. Current approaches rely on fine-tuning…

机器学习 · 计算机科学 2025-10-27 Srivathsan Badrinarayanan , Yue Su , Janghoon Ock , Alan Pham , Sanya Ahuja , Amir Barati Farimani

Metamorphic Testing (MT) is a testing technique that can effectively alleviate the oracle problem. MT uses Metamorphic Relations (MRs) to determine if a test case passes or fails. MRs specify how the outputs should vary in response to…

软件工程 · 计算机科学 2023-05-19 Alejandra Duque-Torres , Dietmar Pfahl , Claus Klammer , Stefan Fischer

This paper presents an automated tool called Morphy for datamorphic testing. It classifies software test artefacts into test entities and test morphisms, which are mappings on testing entities. In addition to datamorphisms, metamorphisms…

软件工程 · 计算机科学 2019-12-23 Hong Zhu , Ian Bayley , Dongmei Liu , Xiaoyu Zheng

This article discusses the challenges of testing software systems with increasingly integrated AI and LLM functionalities. LLMs are powerful but unreliable, and labeled ground truth for testing rarely scales. Metamorphic Testing solves this…

软件工程 · 计算机科学 2026-03-27 Valerio Terragni

Metamorphic Testing (MT) addresses the test oracle problem by examining the relations between inputs and outputs of test executions. Such relations are known as Metamorphic Relations (MRs). In current practice, identifying and selecting…

软件工程 · 计算机科学 2022-07-28 Alejandra Duque-Torres , Dietmar Pfahl , Rudolf Ramler , Claus Klammer

Metamorphic testing has become one mainstream technique to address the notorious oracle problem in software testing, thanks to its great successes in revealing real-life bugs in a wide variety of software systems. Metamorphic relations, the…

软件工程 · 计算机科学 2024-06-12 Rui Li , Huai Liu , Pak-Lok Poon , Dave Towey , Chang-Ai Sun , Zheng Zheng , Zhi Quan Zhou , Tsong Yueh Chen

Deepfakes utilise Artificial Intelligence (AI) techniques to create synthetic media where the likeness of one person is replaced with another. There are growing concerns that deepfakes can be maliciously used to create misleading and…

计算机视觉与模式识别 · 计算机科学 2022-06-02 Nyee Thoang Lim , Meng Yi Kuan , Muxin Pu , Mei Kuan Lim , Chun Yong Chong

Metamorphic testing is a popular approach that aims to alleviate the oracle problem in software testing. At the core of this approach are Metamorphic Relations (MRs), specifying properties that hold among multiple test inputs and…

软件工程 · 计算机科学 2024-06-06 Jon Ayerdi , Valerio Terragni , Gunel Jahangirova , Aitor Arrieta , Paolo Tonella

Regression is one of the most commonly used statistical techniques. However, testing regression systems is a great challenge because of the absence of test oracle in general. In this paper, we show that Metamorphic Testing is an effective…

统计方法学 · 统计学 2021-08-24 Quang-Hung Luu , Man F. Lau , Sebastian P. H. Ng , Tsong Yueh Chen

Metamorphic testing is a well known approach to tackle the oracle problem in software testing. This technique requires the use of source test cases that serve as seeds for the generation of follow-up test cases. Systematic design of test…

软件工程 · 计算机科学 2018-02-22 Prashanta Saha , Upulee Kanewala

Unsupervised machine learning is the training of an artificial intelligence system using information that is neither classified nor labeled, with a view to modeling the underlying structure or distribution in a dataset. Since unsupervised…

软件工程 · 计算机科学 2020-03-18 Xiaoyuan Xie , Zhiyi Zhang , Tsong Yueh Chen , Yang Liu , Pak-Lok Poon , Baowen Xu

Metamorphic testing seeks to validate software in the absence of test oracles. Our application domain is ocean modeling, where test oracles often do not exist, but where symmetries of the simulated physical systems are known. In this short…

软件工程 · 计算机科学 2020-09-04 Dilip J. Hiremath , Martin Claus , Wilhelm Hasselbring , Willi Rath

In many industrial domains, the Functional Mock-up Interface (FMI) is used to exchange simulation models as Functional Mock-up Units (FMUs) across different partners using various modelling tools. This opens up the possibilities for…

The remarkable success of AlphaFold2 in providing accurate atomic-level prediction of protein structures from their amino acid sequence has transformed approaches to the protein folding problem. However, its core paradigm of mapping one…

应用统计 · 统计学 2025-12-12 Yongkai Chen , Samuel WK Wong , SC Kou

This paper presents a data-driven framework to improve the trustworthiness of US tax preparation software systems. Given the legal implications of bugs in such software on its users, ensuring compliance and trustworthiness of tax…

软件工程 · 计算机科学 2023-02-14 Saeid Tizpaz-Niari , Verya Monjezi , Morgan Wagner , Shiva Darian , Krystia Reed , Ashutosh Trivedi

Security testing aims at verifying that the software meets its security properties. In modern Web systems, however, this often entails the verification of the outputs generated when exercising the system with a very large set of inputs.…

软件工程 · 计算机科学 2023-03-09 Nazanin Bayati Chaleshtari , Fabrizio Pastore , Arda Goknil , Lionel C. Briand

Accurately modeling the protein fitness landscapes holds great importance for protein engineering. Recently, due to their capacity and representation ability, pre-trained protein language models have achieved state-of-the-art performance in…

生物大分子 · 定量生物学 2024-02-06 Ziyi Zhou , Liang Zhang , Yuanxi Yu , Mingchen Li , Liang Hong , Pan Tan

Metamorphic testing seeks to verify software in the absence of test oracles. Our application domain is ocean system modeling, where test oracles rarely exist, but where symmetries of the simulated physical systems are known. The input data…

软件工程 · 计算机科学 2021-03-18 Dilip Jagadeeshwarswamy Hiremath , Martin Claus , Wilhelm Hasselbring , Willi Rath

With the sharp rise in software dependability and failure cost, high quality has been in great demand. However, guaranteeing high quality in software systems which have grown in size and complexity coupled with the constraints imposed on…

软件工程 · 计算机科学 2016-01-08 Bassey Isong , Obeten Ekabua

Proteins exist as a dynamic ensemble of multiple conformations, and these motions are often crucial for their functions. However, current structure prediction methods predominantly yield a single conformation, overlooking the conformational…