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Ontology matching (OM) plays an essential role in enabling semantic interoperability and integration across heterogeneous knowledge sources, particularly in the biomedical domain which contains numerous complex concepts related to diseases…

人工智能 · 计算机科学 2026-04-03 Yiping Song , Jiaoyan Chen , Renate A. Schmidt

Gene expression is a cellular process that plays a fundamental role in human phenotypical variations and diseases. Despite advances of deep learning models for gene expression prediction, recent benchmarks have revealed their inability to…

细胞行为 · 定量生物学 2024-10-04 Edouardo Honig , Huixin Zhan , Ying Nian Wu , Zijun Frank Zhang

Alignment of large language models (LLMs) with human preferences typically relies on supervised reward models or external judges that demand abundant annotations. However, in fields that rely on professional knowledge, such as medicine and…

人工智能 · 计算机科学 2025-11-18 Yiyang Zhao , Huiyu Bai , Xuejiao Zhao

Neural network models of real-world systems, such as industrial processes, made from sensor data must often rely on incomplete data. System states may not all be known, sensor data may be biased or noisy, and it is not often known which…

神经与进化计算 · 计算机科学 2007-06-08 Donald A. Sofge , David L. Elliott

Here we propose an evolutionary algorithm that self modifies its operators at the same time that candidate solutions are evolved. This tackles convergence and lack of diversity issues, leading to better solutions. Operators are represented…

神经与进化计算 · 计算机科学 2017-12-19 Andres Felipe Cruz Salinas , Jonatan Gomez Perdomo

We analyse the search behaviour of genetic programming for symbolic regression in practically relevant but limited settings, allowing exhaustive enumeration of all solutions. This enables us to quantify the success probability of finding…

神经与进化计算 · 计算机科学 2026-03-30 Gabriel Kronberger , Fabricio Olivetti de Franca , Harry Desmond , Deaglan J. Bartlett , Lukas Kammerer

Fine-tuning Large Language Models (LLMs) has become a crucial technique for adapting pre-trained models to downstream tasks. However, the enormous size of LLMs poses significant challenges in terms of computational complexity and resource…

计算与语言 · 计算机科学 2024-10-28 Yifei Zhang , Hao Zhu , Aiwei Liu , Han Yu , Piotr Koniusz , Irwin King

Semantic GP is a promising approach that introduces semantic awareness during genetic evolution. This paper presents a new Semantic GP approach based on Dynamic Target (SGP-DT) that divides the search problem into multiple GP runs. The…

神经与进化计算 · 计算机科学 2020-02-03 Stefano Ruberto , Valerio Terragni , Jason H. Moore

Finding biologically plausible alternatives to back-propagation of errors is a fundamentally important challenge in artificial neural network research. In this paper, we propose a learning algorithm called error-driven Local Representation…

神经与进化计算 · 计算机科学 2018-11-19 Alexander G. Ororbia , Ankur Mali

Designing functional transition metal complexes (TMCs) faces challenges due to the vast search space of metals and ligands, requiring efficient optimization strategies. Traditional genetic algorithms (GAs) are commonly used, employing…

化学物理 · 物理学 2024-10-25 Jieyu Lu , Zhangde Song , Qiyuan Zhao , Yuanqi Du , Yirui Cao , Haojun Jia , Chenru Duan

Fine-tuned Large Language Models (LLMs) often suffer from overconfidence and poor calibration, particularly when fine-tuned on small datasets. To address these challenges, we propose a simple combination of Low-Rank Adaptation (LoRA) with…

计算与语言 · 计算机科学 2024-07-23 Emre Onal , Klemens Flöge , Emma Caldwell , Arsen Sheverdin , Vincent Fortuin

While linear mixed model (LMM) has shown a competitive performance in correcting spurious associations raised by population stratification, family structures, and cryptic relatedness, more challenges are still to be addressed regarding the…

机器学习 · 计算机科学 2023-02-15 Wenting Ye , Xiang Liu , Tianwei Yue , Wenping Wang

Transformer Semantic Genetic Programming (TSGP) is a semantic search approach that uses a pre-trained transformer model as a variation operator to generate offspring programs with high semantic similarity to a given parent. Unlike other…

机器学习 · 计算机科学 2026-05-01 Philipp Anthes , Dominik Sobania , Franz Rothlauf

Meta-learning models, or models that learn to learn, have been a long-desired target for their ability to quickly solve new tasks. Traditional meta-learning methods can require expensive inner and outer loops, thus there is demand for…

神经与进化计算 · 计算机科学 2021-03-12 Kevin Frans , Olaf Witkowski

Large Language Models (LLMs) are increasingly adopted as conversational assistants in genomics, where they are mainly used to reason over biological knowledge, annotations, and analysis outputs through natural language interfaces. However,…

基因组学 · 定量生物学 2026-04-08 Weicai Long , Yusen Hou , Junning Feng , Houcheng Su , Shuo Yang , Donglin Xie , Yanlin Zhang

Many real world problems are NP-Hard problems are a very large part of them can be represented as graph based problems. This makes graph theory a very important and prevalent field of study. In this work a new bio-inspired meta-heuristics…

神经与进化计算 · 计算机科学 2013-10-15 Chiranjib Sur , Anupam Shukla

This paper discusses scalability of standard genetic programming (GP) and the probabilistic incremental program evolution (PIPE). To investigate the need for both effective mixing and linkage learning, two test problems are considered:…

神经与进化计算 · 计算机科学 2007-05-23 Radovan Ondas , Martin Pelikan , Kumara Sastry

Generative AI (GenAI) models, particularly large language models (LLMs), have transformed multiple domains, including natural language processing, software analysis, and code understanding. Their ability to analyze and generate code has…

软件工程 · 计算机科学 2025-11-18 Mohammad Meymani , Hamed Jelodar , Parisa Hamedi , Roozbeh Razavi-Far , Ali A. Ghorbani

Genomic signal processing has been used successfully in bioinformatics to analyze biomolecular sequences and gain varied insights into DNA structure, gene organization, protein binding, sequence evolution, etc. But challenges remain in…

基因组学 · 定量生物学 2022-11-04 Saish Jaiswal , Shreya Nema , Hema A Murthy , Manikandan Narayanan

Combining existing pre-trained expert LLMs is a promising avenue for scalably tackling large-scale and diverse tasks. However, selecting task-level experts is often too coarse-grained, as heterogeneous tasks may require different expertise…

计算与语言 · 计算机科学 2025-07-22 Justin Chih-Yao Chen , Sukwon Yun , Elias Stengel-Eskin , Tianlong Chen , Mohit Bansal
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