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Nanoparticle drug carriers play an important role in facilitating efficient targeted drug delivery, i.e., improving treatment success and reducing drug costs and side effects. However, the mobility of nanoparticle drug carriers poses a…

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, highlighting the urgent need for advanced therapeutic strategies. Nanoparticle-based drug delivery systems have emerged as a promising approach to…

Nanocarriers are nanosized materials commonly used for targeted-oriented delivery of active compounds, including antimicrobials and small-molecular drugs. They equally represent fundamental and engineering challenges since sophisticated…

软凝聚态物质 · 物理学 2021-01-19 François Sicard , Jhoan Toro-Mendoza

This paper considers the scenario of a targeted drug delivery system, which consists of deploying a number of biological nanomachines close to a biological target (e.g. a tumor), able to deliver drug molecules in the diseased area. Suitably…

新兴技术 · 计算机科学 2018-08-14 Mauro Femminella , Gianluca Reali , Athanasios V. Vasilakos

Effective and controlled drug delivery systems with on-demand release abilities and biocompatible properties receive enormous attention for biomedical applications. Here, we describe a novel inorganic-organic hybrid material with a…

软凝聚态物质 · 物理学 2015-09-09 Stefan Datz , Hanna Engelke , Constantin v. Schirnding , Linh Nguyen , Thomas Bein

Molecular communications is a promising framework for the design of controlled-release drug delivery systems. Under this framework, drug carriers, diseased cells, and the channel are modeled as transmitters, absorbing receivers, and…

Recently, bacterial nanocellulose (BNC), a biological material produced by non-pathogenic bacteria that possesses excellent material properties for various medical applications, has received increased interest as a carrier system for drug…

信号处理 · 电气工程与系统科学 2026-03-03 Sebastian Lotter , Marco Seiter , Maryam Pirmoradi , Lukas Brand , Dagmar Fischer , Robert Schober

Thermoresponsive hydrogels have been studied intensively for creating smart drug carriers and controlled drug delivery. Understanding the drug release kinetics and corresponding transport mechanisms of nanoparticles (NPs) in a…

软凝聚态物质 · 物理学 2020-05-12 Yi Wang , Zhen Li , Jie Ouyang , George Em Karniadakis

Drug delivery devices based on nanocomposite membranes containing thermoresponsive nanogels and superparamagnetic nanoparticles have been demonstrated to provide reversible, on-off drug release upon application (and removal) of an…

Hydrophobically modified magnetic nanoparticles (MNPs) were encapsulated within the membrane of poly(trimethylene carbonate)-b-poly(L-glutamic acid) (PTMC-b-PGA) block copolymer vesicles using a nanoprecipitation process. This formulation…

The determination of hydrogenous content in commercial cargoes is an important challenge in cargo security. Prior work has shown the feasibility of hydrogenous cargo classification in radiographic applications. This result was achieved by…

仪器与探测器 · 物理学 2019-10-23 Jill Rahon , Areg Danagoulian

Colorectal cancer (CRC) continues to be a significant global health burden, prompting the need for more effective and targeted therapeutic strategies. Nanoparticle-based drug delivery systems have emerged as a promising approach to address…

其他定量生物学 · 定量生物学 2024-09-10 Mahadi Hasan , Camryn Grace Evett , Jack Burton

The nuclear pore supports molecular communication between cytoplasm and nucleus in eukaryotic cells. Selective transport of proteins is mediated by soluble receptors, whose regulation by the small GTPase Ran leads to cargo accumulation in,…

亚细胞过程 · 定量生物学 2009-03-17 R. B. Kopito , M. Elbaum

We present an electrophoretic platform based on 3D hollow nanoelectrodes capable of controlling and quantifying the intracellular delivery of single nanoparticles in single selected cells by surface-enhanced Raman spectroscopy (SERS). The…

Effective and controlled drug delivery systems with on-demand release and targeting abilities have received enormous attention for biomedical applications. Here, we describe a novel enzyme-based cap system for mesoporous silica…

A novel concept of nano-scaled interwoven templates for drug delivery with alternating hydro- and lipophilicity properties is introduced. They are built from cellulose and peptide hydrogel in tandem, and characterized by a nano-stacked…

Experimental investigations of hydrophobic/water interfaces often return controversial results, possibly due to the unknown role of gas accumulation at the interfaces. Here, during advanced atomic force microscopy of the initial evolution…

介观与纳米尺度物理 · 物理学 2015-12-29 Ing-Shouh Hwang , Chung-Kai Fang , Hsien-Chen Ko , Chih-Wen Yang , Yi-Hsien Lu

Bottom-up production of semiconductor nanomaterials is often accompanied by inhomogeneity resulting in a spread in electronic properties which may be influenced by the nanoparticle geometry, crystal quality, stoichiometry or doping. Using…

The effect of sequence heterogeneity on polynucleotide translocation across a pore and on simple models of molecular motors such as helicases, DNA polymerase/exonuclease and RNA polymerase is studied in detail. Pore translocation of RNA or…

统计力学 · 物理学 2009-11-10 Yariv Kafri , David K. Lubensky , David R. Nelson

Drug delivery systems represent a promising strategy to treat cancer and to overcome the side effects of chemotherapy. In particular, polymeric nanocontainers have attracted major interest because of their structural and morphological…

医学物理 · 物理学 2020-01-10 G. Pontrelli , G. Toniolo , S. McGinty , D. Peri , S. Succi , C. Chatgilialoglu
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