相关论文: PyBioNetFit and the Biological Property Specificat…

We present PrismSSL, a Python library that unifies state-of-the-art self-supervised learning (SSL) methods across audio, vision, graphs, and cross-modal settings in a single, modular codebase. The goal of the demo is to show how researchers…

In an effort to catalog insect biodiversity, we propose a new large dataset of hand-labelled insect images, the BIOSCAN-Insect Dataset. Each record is taxonomically classified by an expert, and also has associated genetic information…

The problem of inferring proteins from complex peptide samples in shotgun proteomic workflow sets extreme demands on computational resources. This is exacerbated by the fact that, in general, a given protein cannot be defined by a fixed…

To facilitate flexible and efficient structural bioinformatics analyses, new functionality for three-dimensional structure processing and analysis has been introduced into PyCogent -- a popular feature-rich framework for sequence-based…

We address the problem of parameter estimation in models of systems biology from noisy observations. The models we consider are characterized by simultaneous deterministic nonlinear differential equations whose parameters are either taken…

Progress in anatomical 3D shape classification is limited by the complexity of mesh data and the lack of standardized benchmarks, highlighting the need for robust learning methods and reproducible evaluation. We introduce two key steps…

Context and motivation: Software Product Lines (SPL) enable the creation of software product families with shared core components using feature models to model variability. Choosing features from a feature model to generate a product may…

We present an automated framework for solidifying the cohesion between software specifications, their dependently typed models, and implementation at compile time. Model Checking and type checking are currently separate techniques for…

Protein language models (pLMs) have recently gained significant attention for their ability to uncover relationships between sequence, structure, and function from evolutionary statistics, thereby accelerating therapeutic drug discovery.…

While effective, the backpropagation (BP) algorithm exhibits limitations in terms of biological plausibility, computational cost, and suitability for online learning. As a result, there has been a growing interest in developing alternative…

Protein language models have shown remarkable success in learning biological information from protein sequences. However, most existing models are limited by either autoencoding or autoregressive pre-training objectives, which makes them…

Biological regulatory networks can be represented by computational models, which allow the study and analysis of biological behaviours, therefore providing a better understanding of a given biological process. However, as new information is…

We investigate the parameterized complexity of Bayesian Network Structure Learning (BNSL), a classical problem that has received significant attention in empirical but also purely theoretical studies. We follow up on previous works that…

The rapid growth of scientific software has created practical barriers for bioinformatics research. Although powerful statistical, artificial intelligence (AI)-based methods are now widely available, their effective use is often hindered by…

Despite the widespread success of self-supervised learning via masked language models (MLM), accurately capturing fine-grained semantic relationships in the biomedical domain remains a challenge. This is of paramount importance for…

Can language models read biomedical texts and explain the biomedical mechanisms discussed? In this work we introduce a biomedical mechanism summarization task. Biomedical studies often investigate the mechanisms behind how one entity (e.g.,…

Protein retrieval, which targets the deconstruction of the relationship between sequences, structures and functions, empowers the advancing of biology. Basic Local Alignment Search Tool (BLAST), a sequence-similarity-based algorithm, has…

Large language models (LLMs) have demonstrated remarkable capabilities across diverse domains, but their heavy resource demands make quantization-reducing precision to lower-bit formats-critical for efficient serving. While many…

Behavioral models are the key enablers for behavioral analysis of Software Product Lines (SPL), including testing and model checking. Active model learning comes to the rescue when family behavioral models are non-existent or outdated. A…

The application of Natural Language Processing (NLP) has achieved a high level of relevance in several areas. In the field of software engineering (SE), NLP applications are based on the classification of similar texts (e.g. software…