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Cancer pathological analysis requires modeling tumor heterogeneity across multiple modalities, primarily through transcriptomics and whole slide imaging (WSI), along with their spatial relations. On one hand, bulk transcriptomics and WSI…

机器学习 · 计算机科学 2026-03-17 Jingkun Yu , Guangkai Shang , Changtao Li , Xun Gong , Tianrui Li , Yazhou He , Zhipeng Luo

Significance: Diffuse in-vivo Flow Cytometry (DiFC) is an emerging fluorescence sensing method to non-invasively detect labeled circulating cells in-vivo. However, due to Signal-to-Noise Ratio (SNR) constraints largely attributed to…

医学物理 · 物理学 2023-08-04 Giles Blaney , Fernando Ivich , Angelo Sassaroli , Mark Niedre , Sergio Fantini

We propose a method to accurately obtain the ratio of tumor cells over an entire histological slide. We use deep fully convolutional neural network models trained to detect and classify cells on images of H&E-stained tissue sections.…

图像与视频处理 · 电气工程与系统科学 2021-01-29 Eric Cosatto , Kyle Gerard , Hans-Peter Graf , Maki Ogura , Tomoharu Kiyuna , Kanako C. Hatanaka , Yoshihiro Matsuno , Yutaka Hatanaka

Traditional fluorescence staining is phototoxic to live cells, slow, and expensive; thus, the subcellular structure prediction (SSP) from transmitted light (TL) images is emerging as a label-free, faster, low-cost alternative. However,…

计算机视觉与模式识别 · 计算机科学 2024-07-04 Jintu Zheng , Yi Ding , Qizhe Liu , Yi Cao , Ying Hu , Zenan Wang

Intelligent reflecting surface (IRS) has drawn a lot of attention recently as a promising new solution to achieve high spectral and energy efficiency for future wireless networks. By utilizing massive low-cost passive reflecting elements,…

信息论 · 计算机科学 2022-10-17 Ming-Min Zhao , Qingqing Wu , Min-Jian Zhao , Rui Zhang

Identifying concentrations of components from an observed mixture is a fundamental problem in signal processing. It has diverse applications in fields ranging from hyperspectral imaging to denoising biomedical sensors. This paper focuses on…

计算工程、金融与科学 · 计算机科学 2016-11-17 Shahin Mohammadi , Neta Zuckerman , Andrea Goldsmith , Ananth Grama

Tissue oxygenation and perfusion can be an indicator for organ viability during minimally invasive surgery, for example allowing real-time assessment of tissue perfusion and oxygen saturation. Multispectral imaging is an optical modality…

计算机视觉与模式识别 · 计算机科学 2017-06-23 Geoffrey Jones , Neil T Clancy , Xiaofei Du , Maria Robu , Simon Arridge , Daniel S Elson , Danail Stoyanov

Resistive Pulse Sensing (RPS) is a key label-free technology to measure particles and single-cell size distribution. As a growing corpus of evidence supports that cancer cells exhibit distinct mechanical phenotypes from healthy cells,…

生物物理 · 物理学 2020-04-01 Antoine Riaud , Anh L. P. Thai , Wei Wang , Valerie Taly

Segmenting tumors in histological images is vital for cancer diagnosis. While fully supervised models excel with pixel-level annotations, creating such annotations is labor-intensive and costly. Accurate histopathology image segmentation…

计算机视觉与模式识别 · 计算机科学 2024-07-16 Yinsheng He , Xingyu Li , Roger J. Zemp

The estimation and monitoring of SpO2 are crucial for assessing lung function and treating chronic pulmonary diseases. The COVID-19 pandemic has highlighted the importance of early detection of changes in SpO2, particularly in asymptomatic…

计算机视觉与模式识别 · 计算机科学 2023-05-01 Rohit Sharma , Abhinav Gupta , Arnav Gupta , Bo Li

Purpose: To introduce a novel deep learning method for Robust and Accelerated Reconstruction (RoAR) of quantitative and B0-inhomogeneity-corrected R2* maps from multi-gradient recalled echo (mGRE) MRI data. Methods: RoAR trains a…

图像与视频处理 · 电气工程与系统科学 2020-05-15 Max Torop , Satya VVN Kothapalli , Yu Sun , Jiaming Liu , Sayan Kahali , Dmitriy A. Yablonskiy , Ulugbek S. Kamilov

Despite recent advances in the field of Oncoimmunology, the success potential of immunomodulatory therapies against cancer remains to be elucidated. One of the reasons is the lack of understanding on the complex interplay between tumor…

组织与器官 · 定量生物学 2015-07-24 A. I. Reppas , J. C. L. Alfonso , H. Hatzikirou

Estimating parameters and properties of various materials without causing damage to the material under test (MUT) is important in many applications. Thus, in this letter, we address this by wireless sensing. Here, the accuracy of the…

信号处理 · 电气工程与系统科学 2020-10-29 Udaya S. K. P. Miriya Thanthrige , Jan Barowski , Ilona Rolfes , Daniel Erni , Thomas Kaiser , Aydin Sezgin

Objective: Clinical implementation of deformable image registration (DIR) requires voxel-based spatial accuracy metrics such as manually identified landmarks, which are challenging to implement for highly mobile gastrointestinal (GI)…

In radial fast spin-echo MRI, a set of overlapping spokes with an inconsistent T2 weighting is acquired, which results in an averaged image contrast when employing conventional image reconstruction techniques. This work demonstrates that…

医学物理 · 物理学 2016-03-02 Kai Tobias Block , Martin Uecker , Jens Frahm

Positron emission tomography (PET) scans expose patients to radiation, which can be mitigated by reducing the dose, albeit at the cost of diminished quality. This makes low-dose (LD) PET recovery an active research area. Previous studies…

图像与视频处理 · 电气工程与系统科学 2026-03-11 Ghulam Nabi Ahmad Hassan Yar , Himashi Peiris , Victoria Mar , Cameron Dennis Pain , Zhaolin Chen

Ultrasound computed tomography (USCT) quantifies acoustic tissue properties such as the speed-of-sound (SOS). Although full-waveform inversion (FWI) is an effective method for accurate SOS reconstruction, it can be computationally…

图像与视频处理 · 电气工程与系统科学 2024-10-15 Gangwon Jeong , Fu Li , Trevor M. Mitcham , Umberto Villa , Nebojsa Duric , Mark A. Anastasio

Advanced diffusion models have made notable progress in text-to-image compositional generation. However, it is still a challenge for existing models to achieve text-image alignment when confronted with complex text prompts. In this work, we…

计算机视觉与模式识别 · 计算机科学 2025-05-07 Chang Xie , Chenyi Zhuang , Pan Gao

Multiplexed immuno-fluorescence tissue imaging, allowing simultaneous detection of molecular properties of cells, is an essential tool for characterizing the complex cellular mechanisms in translational research and clinical practice. New…

In wireless communication systems, dual-polarized (DP) instead of single-polarized (SP) multiple-input multiple-output (MIMO) transmission is used to improve the spectral efficiency under certain conditions on the channel and the…

信息论 · 计算机科学 2013-09-13 Adrian Ispas , Xitao Gong , Christian Schneider , Gerd Ascheid , Reiner Thomä