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In this paper, we propose a robust method to estimate the average treatment effects in observational studies when the number of potential confounders is possibly much greater than the sample size. We first use a class of penalized…

统计方法学 · 统计学 2018-12-21 Yang Ning , Sida Peng , Kosuke Imai

Causal inference is crucial for understanding the true impact of interventions, policies, or actions, enabling informed decision-making and providing insights into the underlying mechanisms that shape our world. In this paper, we establish…

统计方法学 · 统计学 2024-03-26 Jingyue Huang , Changbao Wu , Leilei Zeng

Causal inference methods based on electronic health record (EHR) databases must simultaneously handle confounding and missing data. Vast scholarship exists aimed at addressing these two issues separately, but surprisingly few papers attempt…

统计方法学 · 统计学 2025-07-28 Luke Benz , Alexander Levis , Sebastien Haneuse

The propensity score analysis is one of the most widely used methods for studying the causal treatment effect in observational studies. This paper studies treatment effect estimation with the method of matching weights. This method…

统计方法学 · 统计学 2011-05-17 Liang Li

PURPOSE: Clinical examinations are performed on the basis of necessity. However, our decisions to investigate and document are influenced by various other factors, such as workload and preconceptions. Data missingness patterns may contain…

应用统计 · 统计学 2019-12-19 Robert O'Shea

Small area ecological studies are commonly used in epidemiology to assess the impact of area level risk factors on health outcomes when data are only available in an aggregated form. However the resulting estimates are often biased due to…

应用统计 · 统计学 2017-01-19 Yingbo Wang , Sylvia Richardson , Anna Hansell , Marta Blangiardo

Data mining and machine learning techniques such as classification and regression trees (CART) represent a promising alternative to conventional logistic regression for propensity score estimation. Whereas incomplete data preclude the…

机器学习 · 统计学 2018-07-26 Bas B. L. Penning de Vries , Maarten van Smeden , Rolf H. H. Groenwold

Missing data is a systemic problem in practical scenarios that causes noise and bias when estimating treatment effects. This makes treatment effect estimation from data with missingness a particularly tricky endeavour. A key reason for this…

机器学习 · 统计学 2023-02-27 Jeroen Berrevoets , Fergus Imrie , Trent Kyono , James Jordon , Mihaela van der Schaar

Missing data is frequently encountered in many areas of statistics. Propensity score weighting is a popular method for handling missing data. The propensity score method employs a response propensity model, but correct specification of the…

统计方法学 · 统计学 2024-03-28 Hengfang Wang , Jae Kwang Kim , Jeongseop Han , Youngjo Lee

When assessing the causal effect of a binary exposure using observational data, confounder imbalance across exposure arms must be addressed. Matching methods, including propensity score-based matching, can be used to deconfound the causal…

统计方法学 · 统计学 2024-10-01 Ernesto Ulloa-Pérez , Marco Carone , Alex Luedtke

Methods for addressing missing data have become much more accessible to applied researchers. However, little guidance exists to help researchers systematically identify plausible missing data mechanisms in order to ensure that these methods…

应用统计 · 统计学 2020-07-29 Adam Davey , Ting Dai

Inferring causal effects of treatments is a central goal in many disciplines. The potential outcomes framework is a main statistical approach to causal inference, in which a causal effect is defined as a comparison of the potential outcomes…

统计方法学 · 统计学 2018-01-04 Peng Ding , Fan Li

Electronic health records (EHR) are widely used to study clinical decisions, yet unmeasured confounding remains a persistent challenge. Proxy variables offer a potential solution. In EHR data, clinicians already record many such…

统计方法学 · 统计学 2026-03-23 Haley Colgate Kottler , Amy Cochran

Missing Not At Random (MNAR) values lead to significant biases in the data, since the probability of missingness depends on the unobserved values.They are ''not ignorable'' in the sense that they often require defining a model for the…

统计理论 · 数学 2020-06-11 Aude Sportisse , Claire Boyer , Julie Josse

Propensity score matching is commonly used to draw causal inference from observational survival data. However, its asymptotic properties have yet to be established, and variance estimation is still open to debate. We derive the statistical…

统计方法学 · 统计学 2024-12-24 Tongrong Wang , Honghe Zhao , Shu Yang , Shuhan Tang , Zhanglin Cui , Li Li , Douglas E. Faries

Patient-reported outcome (PRO) measures are increasingly collected as a means of measuring healthcare quality and value. The capability to predict such measures enables patient-provider shared decision making and the delivery of…

统计方法学 · 统计学 2023-03-01 Jaeyoung Park , Muxuan Liang , Ying-Qi Zhao , Xiang Zhong

U.S. state education agencies mark schools displaying achievement gaps between demographic subgroups as needing improvement. Some schools may have few students in these subgroups, such that average end-of-year test scores only noisily…

统计方法学 · 统计学 2025-12-10 Joshua Wasserman , Michael R. Elliott , Ben B. Hansen

We propose a multiple imputation method based on principal component analysis (PCA) to deal with incomplete continuous data. To reflect the uncertainty of the parameters from one imputation to the next, we use a Bayesian treatment of the…

统计方法学 · 统计学 2015-08-20 Vincent Audigier , François Husson , Julie Josse

Causal inference in observational studies can be challenging when confounders are subject to missingness. Generally, the identification of causal effects is not guaranteed even under restrictive parametric model assumptions when confounders…

统计方法学 · 统计学 2023-03-23 Jian Sun , Bo Fu

Propensity score methods were proposed by Rosenbaum and Rubin [Biometrika 70 (1983) 41--55] as central tools to help assess the causal effects of interventions. Since their introduction more than two decades ago, they have found wide…

统计理论 · 数学 2007-06-13 Donald B. Rubin , Richard P. Waterman