相关论文: Parallel Protein Community Detection in Large-scal…

A wide range of complex systems can be modeled as networks with corresponding constraints on the edges and nodes, which have been extensively studied in recent years. Nowadays, with the progress of information technology, systems that…

The analysis of temporal networks has a wide area of applications in a world of technological advances. An important aspect of temporal network analysis is the discovery of community structures. Real data networks are often very large and…

Community detection is the task of discovering groups of nodes sharing similar patterns within a network. With recent advancements in deep learning, methods utilizing graph representation learning and deep clustering have shown great…

We present a method that compares the protein interaction networks of two species to detect functionally similar (conserved) protein modules between them. The method is based on an algorithm we developed to identify matching subgraphs…

Mitochondrial diseases are largely caused by dysfunction in mitochondrial proteins. However, annotations of human mitochondrial proteins are scattered across various public databases and individual studies. To facilitate research aimed at…

Graph clustering and community detection are central problems in modern data mining. The increasing need for analyzing billion-scale data calls for faster and more scalable algorithms for these problems. There are certain trade-offs between…

Community detection is an important research topic in complex networks. We present the employment of a genetic algorithm to detect communities in complex networks which is based on optimizing network modularity. It does not need any prior…

Structural information about protein-protein interactions, often missing at the interactome scale, is important for mechanistic understanding of cells and rational discovery of therapeutics. Protein docking provides a computational…

As in many other scientific domains, we face a fundamental problem when using machine learning to identify proteins from mass spectrometry data: large ground truth datasets mapping inputs to correct outputs are extremely difficult to…

A common and important problem arising in the study of networks is how to divide the vertices of a given network into one or more groups, called communities, in such a way that vertices of the same community are more interconnected than…

Nowadays, networks are almost ubiquitous. In the past decade, community detection received an increasing interest as a way to uncover the structure of networks by grouping nodes into communities more densely connected internally than…

Community detection in multi-layer undirected networks has attracted considerable attention in recent years. However, multi-layer directed networks are common in the real world, and existing community detection methods often either ignore…

The comparison of computer generated protein structural models is an important element of protein structure prediction. It has many uses including model quality evaluation, selection of the final models from a large set of candidates or…

Network communities represent mesoscopic structure for understanding the organization of real-world networks, where nodes often belong to multiple communities and form overlapping community structure in the network. Due to non-triviality in…

Networks are commonly used to model complex systems. The different entities in the system are represented by nodes of the network and their interactions by edges. In most real life systems, the different entities may interact in different…

We developed an explainable deep learning framework integrating protein-protein interaction (PPI) network centrality metrics with node embeddings for cancer therapeutic target prioritization. A high-confidence PPI network was constructed…

An algorithm for the detection of overlapping natural communities in networks was proposed by Lancichinetti, Fortunato, and Kertesz (LFK) last year. The LFK algorithm constructs natural communities of (in principle) all nodes of a graph by…

Motivation: Assigning statistical significance accurately has become increasingly important as meta data of many types, often assembled in hierarchies, are constructed and combined for further biological analyses. Statistical inaccuracy of…

Infections depend on interactions between pathogen and host proteins, but comprehensively mapping these interactions is challenging and labor intensive. Many biological networks have hierarchical, scale-free structure, so we developed a…

Mining complex data in the form of networks is of increasing interest in many scientific disciplines. Network communities correspond to densely connected subnetworks, and often represent key functional parts of real-world systems. In this…