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Confinement and wall effects are known to affect the kinematics and propulsive characteristics of swimming microorganisms. When a solid body is dragged through a viscous fluid at constant velocity, the presence of a wall increases fluid…

生物物理 · 物理学 2010-10-29 Arthur A. Evans , Eric Lauga

Previously published experimental work by other authors has shown that certain motile marine bacteria are able to track free swimming algae by executing a zigzag path and steering toward the algae at each turn. Here, we propose that the…

细胞行为 · 定量生物学 2008-06-05 Janos Tobias Locsei , Timothy J Pedley

Bacterial conglomerates such as biofilms and microcolonies are ubiquitous in nature and play an important role in industry and medicine. In contrast to well-mixed, diluted cultures routinely used in microbial research, bacteria in a…

生物物理 · 物理学 2017-01-13 Fred F. Farrell , Matti Gralka , Oskar Hallatschek , Bartlomiej Waclaw

Locomotion is essential for living cells. It enables bacteria and algae to explore space for food, cancer to spread, and immune system to fight infections. Motile cells display trajectories of intriguing complexity, from regular (e.g.…

软凝聚态物质 · 物理学 2021-12-28 C. Misbah , M. S. Rizvi , W. F. Hu , T. S. Lin , S. Rafai , A. Farutin

Despite being of vital importance to the immune system, the mechanism by which cells engulf relatively large solid particles during phagocytosis is still poorly understood. From movies of neutrophil phagocytosis of polystyrene beads, we…

细胞行为 · 定量生物学 2014-10-28 David M. Richards , Robert G. Endres

Interaction between active materials and the boundaries of geometrical confinement is key to many emergent phenomena in active systems. For living active matter consisting of animal cells or motile bacteria, the confinement boundary is…

软凝聚态物质 · 物理学 2022-08-29 Haoran Xu , Mehrana R. Nejad , Julia M. Yeomans , Yilin Wu

Bacterial flagellar motor (BFM) is one of the ion-driven molecular machines, which drives the rotation of flagellar filaments and enable bacteria to swim in viscous solutions. Understanding its mechanism is one challenge in biophysics.…

生物物理 · 物理学 2015-03-06 Yunxin Zhang

Swimming microbes, such as bacteria and algae, live in diverse habitats including soil, ocean and human body which are characterized by structural boundaries and heterogeneous fluid flows. Although much progress has been made in…

生物物理 · 物理学 2022-02-16 Kejie Chen , Kairong Qin

Bacteria such as Escherichia coli move about in a series of runs and tumbles: while a run state (straight motion) entails all the flagellar motors spinning in counterclockwise mode, a tumble is caused by a shift in the state of one or more…

定量方法 · 定量生物学 2020-01-08 C. S. Renadheer , Ushasi Roy , Manoj Gopalakrishnan

The interaction between nano- or micro-sized particles and cell membranes is of crucial importance in many biological and biomedical applications such as drug and gene delivery to cells and tissues. During their cellular uptake, the…

We examine the budding of a nanoscale particle through a lipid bilayer using molecular dynamics simulations, free energy calculations, and an elastic theory, with the aim of determining the extent to which equilibrium elasticity theory can…

亚细胞过程 · 定量生物学 2012-02-22 Teresa Ruiz-Herrero , Enrique Velasco , Michael F. Hagan

Bacteria often traverse confined spaces to perform critical functions in symbiosis, infection, drug delivery, and soil bioremediation. While the canonical run-and-tumble strategy enables exploration, its reliance on constant sensing and…

生物物理 · 物理学 2026-03-04 Viet Sang Doan , Ali Nikkhah , Sangwoo Shin

To initiate tumbling of an E. coli, one of the helical flagella reverses its sense of rotation. It then transforms from its normal form first to the transient semicoiled state and subsequently to the curly-I state. The dynamics of…

生物物理 · 物理学 2016-02-23 Tapan Chandra Adhyapak , Holger Stark

Cilia and flagella are essential building blocks for biological fluid transport and locomotion at the micron scale. They often beat in synchrony and may transition between different synchronization modes in the same cell type. Here, we…

流体动力学 · 物理学 2018-02-14 Hanliang Guo , Lisa Fauci , Michael Shelley , Eva Kanso

Many microorganisms propel through complex media by deformations of their flagella. The beat is thought to emerge from interactions between forces of the surrounding fluid, passive elastic response from deformations of the flagellum, and…

流体动力学 · 物理学 2024-01-23 Kathryn G. Link , Robert D. Guy , Becca Thomases , Paulo E. Arratia

We quantitatively study the transport of E. coli near the walls of confined microfluidic channels, and in more detail along the edges formed by the interception of two perpendicular walls. Our experiments establish the connection between…

Many microorganisms and artificial microswimmers use helical appendages in order to generate locomotion. Though often rotated so as to produce thrust, some species of bacteria such Spiroplasma, Rhodobacter sphaeroides and Spirochetes induce…

生物物理 · 物理学 2018-10-23 Lyndon Koens , Hang Zhang , Martin Moeller , Ahmed Mourran , Eric Lauga

Within the germinal center in follicles, B-cells proliferate, mutate and differentiate, while being submitted to a powerful selection~: a micro-evolutionary mechanism at the heart of adaptive immunity. A new foreign pathogen is confronted…

概率论 · 数学 2016-02-12 Irene Balelli , Vuk Milisic , Gilles Wainrib

Left-right axis specification establishes embryonic laterality through asymmetric signaling cascades originating at the cellular scale. We previously reported the presence of a directionality bias in confined pairs of endothelial (and…

细胞行为 · 定量生物学 2026-03-31 Egun Im , Ghina Badih , Laetitia Kurzawa , Andreas Buttenschön , Calina Copos

The persistent dynamics of active particles makes them explore extended portions of an obstacle's boundary during collisions. From impact to escape, the net applied forces depend on the curvature of the wall and increase in the presence of…

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