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Mixed Models for Repeated Measures (MMRMs) are ubiquitous when analyzing outcomes of clinical trials. However, the linearity of the fixed-effect structure in these models largely restrict their use to estimating treatment effects that are…

统计方法学 · 统计学 2023-01-23 Lars Lau Raket

Recent advances in deep learning have led to interest in training deep learning models on longitudinal healthcare records to predict a range of medical events, with models demonstrating high predictive performance. Predictive performance is…

机器学习 · 计算机科学 2022-11-23 Lin Lee Cheong , Tesfagabir Meharizghi , Wynona Black , Yang Guang , Weilin Meng

Deep learning methods have shown promising performance in fault diagnosis for multimode process. Most existing studies assume that the collected health state categories from different operating modes are identical. However, in real…

机器学习 · 计算机科学 2025-10-30 Guangqiang Li , M. Amine Atoui , Xiangshun Li

Multivariate dynamical processes can often be intuitively described by a weighted connectivity graph between components representing each individual time-series. Even a simple representation of this graph as a Pearson correlation matrix may…

机器学习 · 计算机科学 2022-02-15 Usman Mahmood , Zening Fu , Vince Calhoun , Sergey Plis

When we deploy machine learning models in high-stakes medical settings, we must ensure these models make accurate predictions that are consistent with known medical science. Inherently interpretable networks address this need by explaining…

计算机视觉与模式识别 · 计算机科学 2021-10-06 Alina Jade Barnett , Fides Regina Schwartz , Chaofan Tao , Chaofan Chen , Yinhao Ren , Joseph Y. Lo , Cynthia Rudin

Stochastic infectious disease models capture uncertainty in public health outcomes and have become increasingly popular in epidemiological practice. However, calibrating these models to observed data is challenging with existing methods for…

统计方法学 · 统计学 2024-12-18 Prayag Chatha , Fan Bu , Jeffrey Regier , Evan Snitkin , Jon Zelner

Transformer-based models have become state-of-the-art tools in various machine learning tasks, including time series classification, yet their complexity makes understanding their internal decision-making challenging. Existing…

机器学习 · 计算机科学 2025-11-27 Matīss Kalnāre , Sofoklis Kitharidis , Thomas Bäck , Niki van Stein

For many complex diseases, there is a wide variety of ways in which an individual can manifest the disease. The challenge of personalized medicine is to develop tools that can accurately predict the trajectory of an individual's disease,…

机器学习 · 统计学 2016-01-22 Peter Schulam , Suchi Saria

Multiple Sclerosis (MS) is a chronic disease characterized by progressive or alternate impairment of neurological functions (motor, sensory, visual, and cognitive). Predicting disease progression with a probabilistic and time-dependent…

Computational models that forecast the progression of Alzheimer's disease at the patient level are extremely useful tools for identifying high risk cohorts for early intervention and treatment planning. The state-of-the-art work in this…

机器学习 · 计算机科学 2019-12-30 Surya Teja Devarakonda , Joie Yeahuay Wu , Yi Ren Fung , Madalina Fiterau

Deep learning has enabled breakthroughs in automated diagnosis from medical imaging, with many successful applications in ophthalmology. However, standard medical image classification approaches only assess disease presence at the time of…

计算机视觉与模式识别 · 计算机科学 2024-07-31 Gregory Holste , Mingquan Lin , Ruiwen Zhou , Fei Wang , Lei Liu , Qi Yan , Sarah H. Van Tassel , Kyle Kovacs , Emily Y. Chew , Zhiyong Lu , Zhangyang Wang , Yifan Peng

We propose an attention-based method that aggregates local image features to a subject-level representation for predicting disease severity. In contrast to classical deep learning that requires a fixed dimensional input, our method operates…

计算机视觉与模式识别 · 计算机科学 2018-07-02 Sumedha Singla , Mingming Gong , Siamak Ravanbakhsh , Frank Sciurba , Barnabas Poczos , Kayhan N. Batmanghelich

Recently several deep learning based models have been proposed for end-to-end learning of dialogs. While these models can be trained from data without the need for any additional annotations, it is hard to interpret them. On the other hand,…

人工智能 · 计算机科学 2018-11-05 Dhiraj Madan , Dinesh Raghu , Gaurav Pandey , Sachindra Joshi

Recent advances in deep learning have enabled the development of automated frameworks for analysing medical images and signals, including analysis of cervical cancer. Many previous works focus on the analysis of isolated cervical cells, or…

计算机视觉与模式识别 · 计算机科学 2024-03-06 Ruiqi Wang , Mohammad Ali Armin , Simon Denman , Lars Petersson , David Ahmedt-Aristizabal

Multivariate time series (MTS) are ubiquitous in domains such as healthcare, climate science, and industrial monitoring, but their high dimensionality, limited labeled data, and non-stationary nature pose significant challenges for…

机器学习 · 计算机科学 2025-09-09 Jia Wang , Xiao Wang , Chi Zhang

Interpretability is often an essential requirement in medical imaging. Advanced deep learning methods are required to address this need for explainability and high performance. In this work, we investigate whether additional information…

计算机视觉与模式识别 · 计算机科学 2026-02-25 Luisa Gallee , Meinrad Beer , Michael Goetz

Sleep disorders have a major impact on both lifestyle and health. Effective sleep disorder prediction from lifestyle and physiological data can provide essential details for early intervention. This research utilizes three deep time series…

机器学习 · 计算机科学 2024-12-30 Pegah Ahadian , Wei Xu , Sherry Wang , Qiang Guan

Dynamical systems running on the top of complex networks has been extensively investigated for decades. But this topic still remains among the most relevant issues in complex network theory due to its range of applicability. The contact…

物理与社会 · 物理学 2021-02-03 Angélica S. Mata

Accurate diagnosis of Parkinson disease, especially in its early stages, can be a challenging task. The application of machine learning techniques helps improve the diagnostic accuracy of Parkinson disease detection but only few studies…

机器学习 · 计算机科学 2024-12-25 Majid Ali , Hina Shakir , Asia Samreen , Sohaib Ahmed

We present a systematic study of medical-domain interpretability in Large Language Models (LLMs). We study how the LLMs both represent and process medical knowledge through four different interpretability techniques: (1) UMAP projections of…

机器学习 · 计算机科学 2026-02-24 Razvan Marinescu , Victoria-Elisabeth Gruber , Diego Fajardo