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In the field of image-based drug discovery, capturing the phenotypic response of cells to various drug treatments and perturbations is a crucial step. However, existing methods require computationally extensive and complex multi-step…

Large language models (LLMs) are increasingly used to extract structured information from free-text clinical records, but prior work often focuses on single tasks, limited models, and English-language reports. We evaluated 15 open-weight…

Large language models (LLMs) have demonstrated remarkable capabilities for medical question answering and programming, but their potential for generating interpretable computable phenotypes (CPs) is under-explored. In this work, we…

机器学习 · 计算机科学 2025-08-08 Guilherme Seidyo Imai Aldeia , Daniel S. Herman , William G. La Cava

The heterogeneity of data poses a great challenge when data from different sources is to be merged for one application. Solutions for this are offered, for example, by ontology-based data management (OBDM). A challenge of OBDM is the…

信息检索 · 计算机科学 2020-05-15 Andreas Burgdorf , André Pomp , Tobias Meisen

Natural Language Processing (NLP) systems often make use of machine learning techniques that are unfamiliar to end-users who are interested in analyzing clinical records. Although NLP has been widely used in extracting information from…

人机交互 · 计算机科学 2017-07-10 Gaurav Trivedi , Phuong Pham , Wendy Chapman , Rebecca Hwa , Janyce Wiebe , Harry Hochheiser

Our objective in this study is to investigate the behavior of Boolean operators on combining annotation output from multiple Natural Language Processing (NLP) systems across multiple corpora and to assess how filtering by aggregation of…

Driven by privacy protection laws and regulations, unlearning in Large Language Models (LLMs) is gaining increasing attention. However, current research often neglects the interpretability of the unlearning process, particularly concerning…

机器学习 · 计算机科学 2025-04-10 Xiaohua Feng , Yuyuan Li , Chengye Wang , Junlin Liu , Li Zhang , Chaochao Chen

We hypothesize that large language models (LLMs) based on the transformer architecture can enable automated detection of clinical phenotype terms, including terms not documented in the HPO. In this study, we developed two types of models:…

定量方法 · 定量生物学 2023-11-10 Jingye Yang , Cong Liu , Wendy Deng , Da Wu , Chunhua Weng , Yunyun Zhou , Kai Wang

Current deep neural networks (DNNs) can easily overfit to biased training data with corrupted labels or class imbalance. Sample re-weighting strategy is commonly used to alleviate this issue by designing a weighting function mapping from…

机器学习 · 计算机科学 2019-09-30 Jun Shu , Qi Xie , Lixuan Yi , Qian Zhao , Sanping Zhou , Zongben Xu , Deyu Meng

As the immense opportunities enabled by large language models become more apparent, NLP systems will be increasingly expected to excel in real-world settings. However, in many instances, powerful models alone will not yield translational…

计算与语言 · 计算机科学 2023-11-28 Bernal Jimenez Gutierrez , Yuqing Mao , Vinh Nguyen , Kin Wah Fung , Yu Su , Olivier Bodenreider

This research was focused on the efficient collection of experimental Metal-Organic Framework (MOF) data from scientific literature to address the challenges of accessing hard-to-find data and improving the quality of information available…

材料科学 · 物理学 2024-04-23 Wonseok Lee , Yeonghun Kang , Taeun Bae , Jihan Kim

Pretrained Language Models (PLMs) have advanced Natural Language Processing (NLP) tasks significantly, but finetuning PLMs on low-resource datasets poses significant challenges such as instability and overfitting. Previous methods tackle…

计算与语言 · 计算机科学 2024-03-20 Sai Ashish Somayajula , Youwei Liang , Abhishek Singh , Li Zhang , Pengtao Xie

Multimodal language models (MLLMs) require large parameter capacity to align high-dimensional visual features with linguistic representations, making them computationally heavy and difficult to deploy efficiently. We introduce a progressive…

计算机视觉与模式识别 · 计算机科学 2025-12-10 Jawad Ibn Ahad , Maisha Rahman , Amrijit Biswas , Muhammad Rafsan Kabir , Robin Krambroeckers , Sifat Momen , Nabeel Mohammed , Shafin Rahman

Current medical image analysis systems are typically task-specific, requiring separate models for classification and segmentation, and lack the flexibility to support user-defined workflows. To address these challenges, we introduce…

计算机视觉与模式识别 · 计算机科学 2026-01-13 Shadman Sobhan , Kazi Abrar Mahmud , Abduz Zami

Large Language Models (LLMs) have demonstrated remarkable performance across various domains, including healthcare. However, their ability to effectively represent structured non-textual data, such as the alphanumeric medical codes used in…

Large Language Models (LLMs) have fundamentally transformed approaches to Natural Language Processing (NLP) tasks across diverse domains. In healthcare, accurate and cost-efficient text classification is crucial, whether for clinical notes…

计算与语言 · 计算机科学 2026-02-16 Hajar Sakai , Sarah S. Lam

In this work, we consider the medical concept normalization problem, i.e., the problem of mapping a health-related entity mention in a free-form text to a concept in a controlled vocabulary, usually to the standard thesaurus in the Unified…

计算与语言 · 计算机科学 2023-11-21 Zulfat Miftahutdinov , Elena Tutubalina

This paper presents a method for the automated collection and aggregation of unstructured data from diverse web sources, utilizing Large Language Models (LLMs). The primary challenge with existing techniques is their instability when the…

数据库 · 计算机科学 2026-04-21 Vsevolod Lazebnyi , Natalia Tereshkina , Maria Shabarina , Dmitriy Fedorov

Objective: The generalizability of clinical large language models is usually ignored during the model development process. This study evaluated the generalizability of BERT-based clinical NLP models across different clinical settings…

计算与语言 · 计算机科学 2023-03-16 Sicheng Zhou , Nan Wang , Liwei Wang , Ju Sun , Anne Blaes , Hongfang Liu , Rui Zhang

A significant amount of data held in Oncology Electronic Medical Records (EMRs) is contained in unstructured provider notes -- including but not limited to the chemotherapy (or cancer treatment) outcome, different biomarkers, the tumor's…