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Discrete-state stochastic models have become a well-established approach to describe biochemical reaction networks that are influenced by the inherent randomness of cellular events. In the last years severalmethods for accurately…

分子网络 · 定量生物学 2017-07-03 Alexander Lück , Verena Wolf

Understanding how the brain encodes stimuli has been a fundamental problem in computational neuroscience. Insights into this problem have led to the design and development of artificial neural networks that learn representations by…

神经元与认知 · 定量生物学 2025-12-04 Shubham Choudhary , Paul Masset , Demba Ba

Large language models (LLMs) can learn from a few demonstrations provided at inference time. We study this in-context learning phenomenon through the lens of Gaussian Processes (GPs). We build controlled experiments where models observe…

机器学习 · 计算机科学 2026-02-13 Elif Akata , Konstantinos Voudouris , Vincent Fortuin , Eric Schulz

Recent years have seen significant advancements in foundation models through generative pre-training, yet algorithmic innovation in this space has largely stagnated around autoregressive models for discrete signals and diffusion models for…

机器学习 · 计算机科学 2025-03-12 Jiaming Song , Linqi Zhou

Hidden Markov Models (HMMs) are foundational tools for modeling sequential data with latent Markovian structure, yet fitting them to real-world data remains computationally challenging. In this work, we show that pre-trained large language…

机器学习 · 计算机科学 2026-04-27 Yijia Dai , Zhaolin Gao , Yahya Sattar , Sarah Dean , Jennifer J. Sun

Mixture models are a fundamental tool in applied statistics and machine learning for treating data taken from multiple subpopulations. The current practice for estimating the parameters of such models relies on local search heuristics…

机器学习 · 计算机科学 2012-09-07 Animashree Anandkumar , Daniel Hsu , Sham M. Kakade

Maximum mean discrepancy (MMD) has been successfully applied to learn deep generative models for characterizing a joint distribution of variables via kernel mean embedding. In this paper, we present conditional generative moment- matching…

机器学习 · 计算机科学 2016-06-15 Yong Ren , Jialian Li , Yucen Luo , Jun Zhu

One major obstacle towards AI is the poor ability of models to solve new problems quicker, and without forgetting previously acquired knowledge. To better understand this issue, we study the problem of continual learning, where the model…

机器学习 · 计算机科学 2022-09-14 David Lopez-Paz , Marc'Aurelio Ranzato

Sequence discovery tools play a central role in several fields of computational biology. In the framework of Transcription Factor binding studies, motif finding algorithms of increasingly high performance are required to process the big…

定量方法 · 定量生物学 2014-08-27 Nicolò Colombo , Nikos Vlassis

Training deep learning neural networks often requires massive amounts of computational ressources. We propose to sequentially monitor network predictions to trigger retraining only if the predictions are no longer valid. This can reduce…

统计理论 · 数学 2026-01-30 Ansgar Steland

Energy based models (EBMs) are appealing due to their generality and simplicity in likelihood modeling, but have been traditionally difficult to train. We present techniques to scale MCMC based EBM training on continuous neural networks,…

机器学习 · 计算机科学 2020-07-01 Yilun Du , Igor Mordatch

We propose a novel approach to learning the generative neural fields represented by linear combinations of implicit basis networks. Our algorithm learns basis networks in the form of implicit neural representations and their coefficients in…

机器学习 · 计算机科学 2023-10-31 Tackgeun You , Mijeong Kim , Jungtaek Kim , Bohyung Han

The conditional moment problem is a powerful formulation for describing structural causal parameters in terms of observables, a prominent example being instrumental variable regression. A standard approach reduces the problem to a finite…

机器学习 · 计算机科学 2023-03-24 Andrew Bennett , Nathan Kallus

We present doubly stochastic gradient MCMC, a simple and generic method for (approximate) Bayesian inference of deep generative models (DGMs) in a collapsed continuous parameter space. At each MCMC sampling step, the algorithm randomly…

机器学习 · 计算机科学 2016-03-08 Chao Du , Jun Zhu , Bo Zhang

Understanding the reasons for the success of deep neural networks trained using stochastic gradient-based methods is a key open problem for the nascent theory of deep learning. The types of data where these networks are most successful,…

机器学习 · 统计学 2020-12-04 Sebastian Goldt , Marc Mézard , Florent Krzakala , Lenka Zdeborová

Probabilistic graphical models (PGMs) are widely used to discover latent structure in data, but their success hinges on selecting an appropriate model design. In practice, model specification is difficult and often requires iterative…

机器学习 · 计算机科学 2026-04-08 Kevin Zhang , Yixin Wang

We develop a generalized method of moments (GMM) approach for fast parameter estimation in a new class of Dirichlet latent variable models with mixed data types. Parameter estimation via GMM has been demonstrated to have computational and…

统计理论 · 数学 2016-03-24 Shiwen Zhao , Barbara E. Engelhardt , Sayan Mukherjee , David B. Dunson

Goal Recognition (GR) is the problem of recognizing an agent's objectives based on observed actions. Recent data-driven approaches for GR alleviate the need for costly, manually crafted domain models. However, these approaches can only…

人工智能 · 计算机科学 2025-05-21 Matan Shamir , Reuth Mirsky

Learning the intents of an agent, defined by its goals or motion style, is often extremely challenging from just a few examples. We refer to this problem as task concept learning and present our approach, Few-Shot Task Learning through…

人工智能 · 计算机科学 2025-01-14 Aviv Netanyahu , Yilun Du , Antonia Bronars , Jyothish Pari , Joshua Tenenbaum , Tianmin Shu , Pulkit Agrawal

Training deep neural networks is challenging. To accelerate training and enhance performance, we propose PadamP, a novel optimization algorithm. PadamP is derived by applying the adaptive estimation of the p-th power of the second-order…

最优化与控制 · 数学 2025-03-14 Yongqi Li , Xiaowei Zhang