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Confocal laser scanning microscopy (CLSM) stands out as one of the most widely used microscopy techniques, thanks to its three-dimensional imaging capability and its sub-diffraction spatial resolution, achieved through the closure of a…

Oral Squamous Cell Carcinoma (OSCC) is a common type of cancer of the oral epithelium. Despite their high impact on mortality, sufficient screening methods for early diagnosis of OSCC often lack accuracy and thus OSCCs are mostly diagnosed…

Confocal microscopy has long been a cornerstone technique for visualizing complex interactions and processes within cellular structures. However, achieving super-resolution imaging of multiple organelles and their interactions…

光学 · 物理学 2025-08-19 Qinglin Chen , Luwei Wang , Jia Li , Dan Shao , Xiaoyu Weng , Liwei Liu , Dayong Jin , Junle Qu

Deep learning has emerged as a powerful artificial intelligence tool to interpret medical images for a growing variety of applications. However, the paucity of medical imaging data with high-quality annotations that is necessary for…

计算机视觉与模式识别 · 计算机科学 2018-10-02 Faisal Mahmood , Richard Chen , Sandra Sudarsky , Daphne Yu , Nicholas J. Durr

We study the performance of CLAIRE -- a diffeomorphic multi-node, multi-GPU image-registration algorithm, and software -- in large-scale biomedical imaging applications with billions of voxels. At such resolutions, most existing software…

计算机视觉与模式识别 · 计算机科学 2022-09-20 Naveen Himthani , Malte Brunn , Jae-Youn Kim , Miriam Schulte , Andreas Mang , George Biros

In computer-aided diagnosis (CAD) focused on microscopy, denoising improves the quality of image analysis. In general, the accuracy of this process may depend both on the experience of the microscopist and on the equipment sensitivity and…

图像与视频处理 · 电气工程与系统科学 2021-05-04 Fabio Hernán Gil Zuluaga , Francesco Bardozzo , Jorge Iván Ríos Patiño , Roberto Tagliaferri

In recent years, endomicroscopy has become increasingly used for diagnostic purposes and interventional guidance. It can provide intraoperative aids for real-time tissue characterization and can help to perform visual investigations aimed…

计算机视觉与模式识别 · 计算机科学 2019-02-07 Daniele Ravì , Agnieszka Barbara Szczotka , Stephen P Pereira , Tom Vercauteren

This work proposes a green learning (GL) approach to restore medical images. Without loss of generality, we use low-dose computed tomography (LDCT) images as examples. LDCT images are susceptible to noise and artifacts, where the imaging…

计算机视觉与模式识别 · 计算机科学 2026-02-24 Wei Wang , Yixing Wu , C. -C. Jay Kuo

Endoscopy is the most widely used imaging technique for the diagnosis of cancerous lesions in hollow organs. However, endoscopic images are often affected by illumination artefacts: image parts may be over- or underexposed according to the…

Intra-operative measurements of tissue shape and multi/ hyperspectral information have the potential to provide surgical guidance and decision making support. We report an optical probe based system to combine sparse hyperspectral…

计算机视觉与模式识别 · 计算机科学 2017-06-22 Jianyu Lin , Neil T. Clancy , Yang Hu , Ji Qi , Taran Tatla , Danail Stoyanov , Lena Maier-Hein , Daniel S. Elson

Confocal microscopy is the standard approach for obtaining volumetric images of a sample with high axial and lateral resolution, especially when dealing with scattering samples. Unfortunately, a confocal microscope is quite expensive…

In this study, we address the key challenges concerning the accuracy and effectiveness of depth estimation for endoscopic imaging, with a particular emphasis on real-time inference and the impact of light reflections. We propose a novel…

计算机视觉与模式识别 · 计算机科学 2024-02-14 Yangke Li

Object segmentation and structure localization are important steps in automated image analysis pipelines for microscopy images. We present a convolution neural network (CNN) based deep learning architecture for segmentation of objects in…

计算机视觉与模式识别 · 计算机科学 2019-01-24 Shan E Ahmed Raza , Linda Cheung , Muhammad Shaban , Simon Graham , David Epstein , Stella Pelengaris , Michael Khan , Nasir M. Rajpoot

Super-resolution reconstruction techniques entail the utilization of software algorithms to transform one or more sets of low-resolution images captured from the same scene into high-resolution images. In recent years, considerable…

计算机视觉与模式识别 · 计算机科学 2024-08-02 Hao Yan , Zixiang Wang , Zhengjia Xu , Zhuoyue Wang , Zhizhong Wu , Ranran Lyu

Estimating disease severity from endoscopic images is essential in assessing ulcerative colitis, where the Mayo Endoscopic Subscore (MES) is widely used to grade inflammation. However, MES classification remains challenging due to label…

计算机视觉与模式识别 · 计算机科学 2025-08-20 Zeynep Ozdemir , Hacer Yalim Keles , Omer Ozgur Tanriover

This paper presents Contrastive Reconstruction, ConRec - a self-supervised learning algorithm that obtains image representations by jointly optimizing a contrastive and a self-reconstruction loss. We showcase that state-of-the-art…

计算机视觉与模式识别 · 计算机科学 2022-02-23 Jonas Dippel , Steffen Vogler , Johannes Höhne

Deep learning (DL) has arguably emerged as the method of choice for the detection and segmentation of biological structures in microscopy images. However, DL typically needs copious amounts of annotated training data that is for biomedical…

图像与视频处理 · 电气工程与系统科学 2020-03-20 Mangal Prakash , Tim-Oliver Buchholz , Manan Lalit , Pavel Tomancak , Florian Jug , Alexander Krull

The segmentation of endoscopic images plays a vital role in computer-aided diagnosis and treatment. The advancements in deep learning have led to the employment of numerous models for endoscopic tumor segmentation, achieving promising…

计算机视觉与模式识别 · 计算机科学 2025-02-03 Lingcong Cai , Yun Li , Xiaomao Fan , Kaixuan Song , Ruxin Wang , Wenbin Lei

Fluorescence microscopy has enabled a dramatic development in modern biology by visualizing biological organisms with micrometer scale resolution. However, due to the diffraction limit, sub-micron/nanometer features are difficult to…

图像与视频处理 · 电气工程与系统科学 2021-03-10 Varun Mannam , Yide Zhang , Xiaotong Yuan , Scott Howard

Pulmonary optical endomicroscopy (POE) is an imaging technology in real time. It allows to examine pulmonary alveoli at a microscopic level. Acquired in clinical settings, a POE image sequence can have as much as 25% of the sequence being…

计算机视觉与模式识别 · 计算机科学 2021-04-20 Thibaud Brochet , Jerome Lapuyade-Lahorgue , Sebastien Bougleux , Mathieu Salaun , Su Ruan