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Intracellular transport of organelles is fundamental to cell function and health. The mounting evidence suggests that this transport is in fact anomalous. However, the reasons for the anomaly is still under debate. We examined experimental…

亚细胞过程 · 定量生物学 2018-12-10 Nickolay Korabel , Thomas A. Waigh , Sergei Fedotov , Viki J. Allan

The cargo motion in living cells transported by two species of motor protein with different intrinsic directionality is discussed in this study. Similar to single motor movement, cargo steps forward and backward along microtubule…

生物物理 · 物理学 2015-03-06 Yunxin Zhang

Molecular motors are specialized proteins which perform active, directed transport of cellular cargoes on cytoskeletal filaments. In many cases, cargo motion powered by motor proteins is found to be bidirectional, and may be viewed as a…

亚细胞过程 · 定量生物学 2015-06-16 Deepak Bhat , Manoj Gopalakrishnan

In intracellular transports, motor proteins transport macromolecules as cargos to desired locations by moving on biopolymers such as microtubules. Recent experiments suggest that cargos that can associate motor proteins during their…

生物物理 · 物理学 2023-07-04 Sutapa Mukherji , Dhruvi K. Patel

Intracellular transport of cargoes in the cell is essential for the organization and functioning cells, especially those that are large and elongated. The cytoskeletal networks inside large cells can be highly complex, and this cytoskeletal…

生物物理 · 物理学 2023-08-04 Nimisha Krishnan , Niranjan Sarpangala , Maria Gamez , Ajay Gopinathan , Jennifer L Ross

Cellular cargo can be bound to cytoskeletal filaments by one or multiple active or passive molecular motors. Recent experiments have shown that the presence of auxiliary, nondriving motors, results in an enhanced processivity of the cargo,…

生物大分子 · 定量生物学 2019-03-27 Filippo Posta , Maria R. D'Orsogna , Tom Chou

Memory effects, sometimes, can not be neglected. In the framework of continuous time random walk, memory effect is modeled by the correlated waiting times. In this paper, we derive the two-point probability distribution of the stochastic…

统计力学 · 物理学 2019-01-23 Yao Chen , Xudong Wang , Weihua Deng

In cellular vortical flows, namely arrays of counter-rotating vortices, short but flexible filaments can show simple random walks through their stretch-coil interactions with flow stagnation points. Here, we study the dynamics of semi-rigid…

软凝聚态物质 · 物理学 2021-08-18 Shi-Yuan Hu , Jun-Jun Chu , Michael J. Shelley , Jun Zhang

We have studied a random walk model based on majority rule. At a given instant, the moving direction of a cargo is determined by motor coordination mediated by a tug-of-war mechanism between two kinds of competing motor proteins. We have…

生物物理 · 物理学 2018-01-03 Hyungseok Chad Moon , Kyungsun Moon

Single kinesin molecular motors can processively move along a microtubule (MT) a few micrometers on average before dissociating. However, cellular length scales over which transport occurs are several hundred microns and more. Why seemingly…

亚细胞过程 · 定量生物学 2019-08-21 Keshav B. Patel , Shengtan Mao , M. Gregory Forest , Samuel K. Lai , Jay M. Newby

The transport of cargo particles which are pulled by several molecular motors in a cooperative manner is studied theoretically. The transport properties depend primarily on the maximal number, $N$, of motor molecules that may pull…

亚细胞过程 · 定量生物学 2007-05-23 Stefan Klumpp , Reinhard Lipowsky

Inside cells, cargos such as vesicles and organelles are transported by molecular motors to their correct locations via active motion on cytoskeletal tracks and passive, Brownian diffusion. During the transportation of cargos, motor-cargo…

软凝聚态物质 · 物理学 2018-04-10 Supravat Dey , Kevin Ching , Moumita Das

L\'evy walks are continuous time random walks with spatio-temporal coupling of jump lengths and waiting times, often used to model superdiffusive spreading processes such as animals searching for food, tracer motion in weakly chaotic…

统计力学 · 物理学 2019-03-27 Bartłomiej Dybiec , Karol Capała , Aleksei Chechkin , Ralf Metzler

Dynein motors exhibit catch bonding, where the unbinding rate of the motors from microtubule filaments decreases with increasing opposing load. The implications of this catch bond on the transport properties of dynein-driven cargo are yet…

生物物理 · 物理学 2023-11-17 Naren Sundararajan , Sougata Guha , Sudipto Muhuri , Mithun K. Mitra

We consider nonequilibrium transport in a simple chain of identical mechanical cells in which particles move around. In each cell, there is a rotating disc, with which these particles interact, and this is the only interaction in the model.…

统计力学 · 物理学 2008-07-15 Jean-Pierre Eckmann , Carlos Mejia-Monasterio , Emmanuel Zabey

Intracellular transport is mediated by molecular motors that pull cargos along cytoskeletal filaments. Many cargos move bidirectionally and are transported by two teams of motors which move into opposite directions along the filament. We…

生物物理 · 物理学 2008-12-16 Melanie J. I. Muller , Stefan Klumpp , Reinhard Lipowsky

Intracellular components explore the cytoplasm via active motor-driven transport in conjunction with passive diffusion. We model the motion of organelles in narrow tubular cells using analytical techniques and numerical simulations to study…

生物物理 · 物理学 2018-04-11 Saurabh Mogre , Elena F. Koslover

The purpose of this paper is to implement a random death process into a persistent random walk model which produces subballistic superdiffusion (L\'{e}vy walk). We develop a Markovian model of cell motility with the extra residence variable…

统计力学 · 物理学 2015-05-20 Sergei Fedotov , Abby Tan , Andrey Zubarev

The ensemble properties and time-averaged observables of a memory-induced diffusive-superdiffusive transition are studied. The model consists in a random walker whose transitions in a given direction depend on a weighted linear combination…

统计力学 · 物理学 2017-05-11 Adrian A. Budini

Active cellular transport is a fundamental mechanism for protein and vesicle delivery, cell cycle and molecular degradation. Viruses can hijack the transport system and use it to reach the nucleus. Most transport processes consist of…

定量方法 · 定量生物学 2009-11-13 T. Lagache , D. Holcman
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