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Cryo-electron tomography (cryo-ET) provides direct 3D visualization of macromolecules inside the cell, enabling analysis of their in situ morphology. This morphology can be regarded as an SE(3)-invariant, denoised volumetric representation…

计算机视觉与模式识别 · 计算机科学 2026-01-06 Mostofa Rafid Uddin , Mahek Vora , Qifeng Wu , Muyuan Chen , Min Xu

Automatic segmentation of medical images is an important task for many clinical applications. In practice, a wide range of anatomical structures are visualised using different imaging modalities. In this paper, we investigate whether a…

计算机视觉与模式识别 · 计算机科学 2017-04-12 Pim Moeskops , Jelmer M. Wolterink , Bas H. M. van der Velden , Kenneth G. A. Gilhuijs , Tim Leiner , Max A. Viergever , Ivana Išgum

Cryo-electron tomography (Cryo-ET) is a powerful tool in structural biology for 3D visualization of cells and biological systems at resolutions sufficient to identify individual proteins in situ. The measurements are collected by tilting…

信号处理 · 电气工程与系统科学 2025-09-03 Vinith Kishore , Valentin Debarnot , AmirEhsan Khorashadizadeh , Ivan Dokmanić

Cryo-electron microscopy (cryo-EM) is a powerful technique for determining the structure of proteins and other macromolecular complexes at near-atomic resolution. In single particle cryo-EM, the central problem is to reconstruct the…

定量方法 · 定量生物学 2020-02-18 Ellen D. Zhong , Tristan Bepler , Joseph H. Davis , Bonnie Berger

Background: Single-particle cryo-electron microscopy (cryo-EM) has become a popular tool for structural determination of biological macromolecular complexes. High-resolution cryo-EM reconstruction often requires hundreds of thousands of…

数据分析、统计与概率 · 物理学 2017-09-05 Yanan Zhu , Qi Ouyang , Youdong Mao

Transforming in-situ transmission electron microscopy (TEM) imaging into a tool for spatially-resolved operando characterization of solid-state reactions requires automated, high-precision semantic segmentation of dynamically evolving…

图像与视频处理 · 电气工程与系统科学 2025-07-23 Yushuo Niu , Tianyu Li , Yuanyuan Zhu , Qian Yang

Cellular electron cryo-tomography enables the 3D visualization of cellular organization in the near-native state and at submolecular resolution. However, the contents of cellular tomograms are often complex, making it difficult to…

定量方法 · 定量生物学 2017-12-29 Xiangrui Zeng , Miguel Ricardo Leung , Tzviya Zeev-Ben-Mordehai , Min Xu

In image-assisted minimally invasive surgeries (MIS), understanding surgical scenes is vital for real-time feedback to surgeons, skill evaluation, and improving outcomes through collaborative human-robot procedures. Within this context, the…

计算机视觉与模式识别 · 计算机科学 2024-12-13 Mithun Parab , Pranay Lendave , Jiyoung Kim , Thi Quynh Dan Nguyen , Palash Ingle

Determining the 3D structures of biological molecules is a key problem for both biology and medicine. Electron Cryomicroscopy (Cryo-EM) is a promising technique for structure estimation which relies heavily on computational methods to…

机器学习 · 统计学 2015-01-29 Ali Punjani , Marcus A. Brubaker

Half of wavefunction information is undetected by conventional transmission electron microscopy (CTEM) as only the intensity, and not the phase, of an image is recorded. Following successful applications of deep learning to optical hologram…

图像与视频处理 · 电气工程与系统科学 2020-01-31 Jeffrey M. Ede , Jonathan J. P. Peters , Jeremy Sloan , Richard Beanland

We introduce a framework for recovering an image from its rotationally and translationally invariant features based on autocorrelation analysis. This work is an instance of the multi-target detection statistical model, which is mainly used…

图像与视频处理 · 电气工程与系统科学 2022-03-03 Nicholas F. Marshall , Ti-Yen Lan , Tamir Bendory , Amit Singer

We propose a 3D convolutional neural network to simultaneously segment and detect cell nuclei in confocal microscopy images. Mirroring the co-dependency of these tasks, our proposed model consists of two serial components: the first part…

图像与视频处理 · 电气工程与系统科学 2018-09-07 Sundaresh Ram , Vicky T. Nguyen , Kirsten H. Limesand , Mert R. Sabuncu

Magnetic resonance imaging (MRI) acquisition, reconstruction, and segmentation are usually processed independently in the conventional practice of MRI workflow. It is easy to notice that there are significant relevances among these tasks…

图像与视频处理 · 电气工程与系统科学 2021-05-17 Zhiwen Wang , Wenjun Xia , Zexin Lu , Yongqiang Huang , Yan Liu , Hu Chen , Jiliu Zhou , Yi Zhang

Single-particle cryo-electron microscopy (cryo-EM) has recently joined X-ray crystallography and NMR spectroscopy as a high-resolution structural method to resolve biological macromolecules. In a cryo-EM experiment, the microscope produces…

信息论 · 计算机科学 2022-10-28 Tamir Bendory , Nicolas Boumal , William Leeb , Eitan Levin , Amit Singer

Automating tissue segmentation and tumor detection in histopathology images of colorectal cancer (CRC) is an enabler for faster diagnostic pathology workflows. At the same time it is a challenging task due to low availability of public…

图像与视频处理 · 电气工程与系统科学 2023-04-07 Lydia A. Schoenpflug , Maxime W. Lafarge , Anja L. Frei , Viktor H. Koelzer

Cryogenic electron microscopy (cryo-EM) provides images from different copies of the same biomolecule in arbitrary orientations. Here, we present an end-to-end unsupervised approach that learns individual particle orientations from cryo-EM…

图像与视频处理 · 电气工程与系统科学 2021-07-08 Youssef S. G. Nashed , Frederic Poitevin , Harshit Gupta , Geoffrey Woollard , Michael Kagan , Chuck Yoon , Daniel Ratner

Piece-wise 3D planar reconstruction provides holistic scene understanding of man-made environments, especially for indoor scenarios. Most recent approaches focused on improving the segmentation and reconstruction results by introducing…

计算机视觉与模式识别 · 计算机科学 2022-02-01 Yaxu Xie , Fangwen Shu , Jason Rambach , Alain Pagani , Didier Stricker

Discovering the 3D atomic structure of molecules such as proteins and viruses is a fundamental research problem in biology and medicine. Electron Cryomicroscopy (Cryo-EM) is a promising vision-based technique for structure estimation which…

计算机视觉与模式识别 · 计算机科学 2016-11-18 Marcus A. Brubaker , Ali Punjani , David J. Fleet

Cryo-electron microscopy (cryo-EM) has revolutionized structural biology by enabling near-atomic-level visualization of biomolecular assemblies. However, the exponential growth in cryo-EM data throughput and complexity, coupled with diverse…

定量方法 · 定量生物学 2026-02-25 Weining Fu , Kai Shu , Kui Xu , Qiangfeng Cliff Zhang

In real-world applications, dynamic scenarios require the models to possess the capability to learn new tasks continuously without forgetting the old knowledge. Experience-Replay methods store a subset of the old images for joint training.…

计算机视觉与模式识别 · 计算机科学 2024-03-13 Xinyuan Gao , Songlin Dong , Yuhang He , Xing Wei , Yihong Gong