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Animal behaviors are sometimes decomposable into discrete, stereotyped elements. In one model, such behaviors are triggered by specific commands; in the extreme case, the discreteness of behavior is traced to the discreteness of action…

神经元与认知 · 定量生物学 2009-12-31 Greg J. Stephens , William S. Ryu , William Bialek

The nematode Caenorhabditis elegans responds to an impressive range of chemical, mechanical and thermal stimuli and is extensively used to investigate the molecular mechanisms that mediate chemosensation, mechanotransduction and…

其他定量生物学 · 定量生物学 2008-02-21 George D. Tsibidis , Nektarios Tavernarakis

The 1mm roundworm C. elegans is a model organism used in many sub-areas of biology to investigate different types of biological processes. In order to complement the n-vivo analysis with computer-based investigations, several methods have…

定量方法 · 定量生物学 2025-10-02 Nemanja Antonic , Monika Scholz , Aymeric Vellinger , Euphrasie Ramahefarivo , Elio Tuci

To establish the relationship between locomotory behavior and dynamics of neural circuits in the nematode C. elegans we combined molecular and theoretical approaches. In particular, we quantitatively analyzed the motion of C. elegans with…

神经元与认知 · 定量生物学 2008-06-10 Jan Karbowski , Gary Schindelman , Chris J. Cronin , Adeline Seah , Paul W. Sternberg

The nematode Caenorhabditis elegans, with information on neural connectivity, three-dimensional position and cell linage provides a unique system for understanding the development of neural networks. Although C. elegans has been widely…

生物物理 · 物理学 2011-01-17 Sreedevi Varier , Marcus Kaiser

The dynamics of complex systems generally include high-dimensional, non-stationary and non-linear behavior, all of which pose fundamental challenges to quantitative understanding. To address these difficulties we detail a new approach based…

定量方法 · 定量生物学 2020-09-11 Antonio Carlos Costa , Tosif Ahamed , Greg J. Stephens

The emerging field of optogenetics allows for optical activation or inhibition of neurons and other tissue in the nervous system. In 2005 optogenetic proteins were expressed in the nematode C. elegans for the first time. Since then, C.…

神经元与认知 · 定量生物学 2013-05-13 Steven J. Husson , Alexander Gottschalk , Andrew M. Leifer

To maximize future rewards in this ever-changing world, animals must be able to discover the temporal structure of stimuli and then anticipate or act correctly at the right time. How the animals perceive, maintain, and use time intervals…

神经元与认知 · 定量生物学 2020-07-08 Zedong Bi , Changsong Zhou

{\it Caenorhabditis elegans} nematode worms are the only animals with the known detailed neural connectivity diagram, well characterized genomics, and relatively simple quantifiable behavioral output. With this in mind, many researchers…

神经元与认知 · 定量生物学 2019-10-17 Jan Karbowski

How do we capture the breadth of behavior in animal movement, from rapid body twitches to aging? Using high-resolution videos of the nematode worm $C. elegans$, we show that a single dynamics connects posture-scale fluctuations with…

生物物理 · 物理学 2024-09-02 Antonio C. Costa , Tosif Ahamed , David Jordan , Greg J. Stephens

An organism's ability to move freely is a fundamental behaviour in the animal kingdom. To understand animal locomotion requires a characterisation of the material properties, as well as the biomechanics and physiology. We present a…

生物物理 · 物理学 2017-02-17 Netta Cohen , Thomas Ranner

C. elegans is commonly used in neuroscience for behaviour analysis because of it's compact nervous system with well-described connectivity. Localizing the animal and distinguishing between its head and tail are important tasks to track the…

计算机视觉与模式识别 · 计算机科学 2020-01-14 Mansi Ranjit Mane , Aniket Anand Deshmukh , Adam J. Iliff

1. Spatial memory plays a role in the way animals perceive their environments, resulting in memory-informed movement patterns that are observable to ecologists. Developing mathematical techniques to understand how animals use memory in…

定量方法 · 定量生物学 2022-02-17 Peter R. Thompson , Andrew E. Derocher , Mark A. Edwards , Mark A. Lewis

Organisms move through the world by changing their shape, and here we explore the mapping from shape space to movements in the nematode C. elegans as it crawls on a planar agar surface. We characterize the statistics of the trajectories…

神经元与认知 · 定量生物学 2016-01-05 Greg J Stephens , Bethany Johnson-Kerner , William Bialek , William S Ryu

Temporal resolution of visual information processing is thought to be an important factor in predator-prey interactions, shaped in the course of evolution by animals' ecology. Here I show that light can be considered to have a dual role of…

神经元与认知 · 定量生物学 2019-10-25 Bartosz Jura

Time perception - how humans and animals perceive the passage of time - forms the basis for important cognitive skills such as decision-making, planning, and communication. In this work, we propose a framework for examining the mechanisms…

系统与控制 · 电气工程与系统科学 2023-11-08 Inês Lourenço , Robert Mattila , Rodrigo Ventura , Bo Wahlberg

The nematode Caenorhabditis elegans is a well-known model organism used to investigate fundamental questions in biology. Motility assays of this small roundworm are designed to study the relationships between genes and behavior. Commonly,…

计算机视觉与模式识别 · 计算机科学 2015-05-19 Raphael Sznitman , Manaswi Gupta , Gregory D. Hager , Paulo E. Arratia , Josue Sznitman

Understanding physical rules underlying collective motions requires perturbation of controllable parameters in self-propelled particles. However, controlling parameters in animals is generally not easy, which makes collective behaviours of…

生物物理 · 物理学 2019-01-31 Takuma Sugi , Hiroshi Ito , Masaki Nishimura , Ken H. Nagai

We study external, electrical perturbations and their responses in the brain dynamic network of the \textit{Caenorhabditis elegans} soil worm, given by the connectome of its large somatic nervous system. Our analysis is inspired by a…

神经元与认知 · 定量生物学 2016-02-17 Chris G. Antonopoulos

Biological circuits such as neural or gene regulation networks use internal states to map sensory input to an adaptive repertoire of behavior. Characterizing this mapping is a major challenge for systems biology, and though experiments that…

神经元与认知 · 定量生物学 2022-10-12 Edward D. Lee , Xiaowen Chen , Bryan C. Daniels