相关论文: AMPA, NMDA and GABAA receptor mediated network bur…

Neuronal networking supports complex brain functions, with neurotransmitters facilitating communication through chemical synapses. The release probability of neurotransmitters varies and is influenced by pre-synaptic neuronal activity.…

NMDA receptors are ion channels activated by the neurotransmitter glutamate in the mammalian brain and are important in synaptic function and plasticity, but are also found in extrasynaptic locations and influence neuronal excitability.…

NMDA receptors (NMDA-R) typically contribute to excitatory synaptic transmission in the central nervous system. While calcium influx through NMDA-R plays a critical role in synaptic plasticity, experimental evidence indicates that…

Collective rhythmic dynamics from neurons is vital for cognitive functions such as memory formation but how neurons self-organize to produce such activity is not well understood. Attractor-based models have been successfully implemented as…

Complexity in the temporal organization of neural systems may be a reflection of the diversity of its neural constituents. These constituents, excitatory and inhibitory neurons, comprise an invariant ratio in vivo and form the substrate for…

Trafficking of AMPA receptors in and out of synapses is crucial for synaptic plasticity. Previous studies have focused on the role of endo/exocytosis processes or that of lateral diffusion of extra-synaptic receptors. We have now directly…

All higher order central nervous systems exhibit spontaneous neural activity, though the purpose and mechanistic origin of such activity remains poorly understood. We explore the ignition and spread of collective spontaneous…

Network architecture forms a critical constraint on neuronal function. Here we examine the role of structural autapses, when a neuron synapses onto itself, in driving network-wide bursting behavior. Using a simple spiking model of neuronal…

Developing networks of neural systems can exhibit spontaneous, synchronous activities called neural bursts, which can be important in the organization of functional neural circuits. Before the network matures, the activity level of a burst…

In this report trial-to-trial variations in the synchronized responses of neural networks are offered as evidence for excitation-inhibition ratio being a dynamic variable over time scales of minutes. Synchronized network responses to…

The importance of self-feedback autaptic transmission in modulating spike-time irregularity is still poorly understood. By using a biophysical model that incorporates autaptic coupling, we here show that self-innervation of neurons…

To gain insight into the neural events responsible for visual perception of static and dynamic optical patterns, we study how neural activation spreads in arrays of inhibition-stabilized neural networks with nearest-neighbor coupling. The…

Inhibition is considered to shape neural activity, and broaden its pattern repertoire. In the sensory organs, where the anatomy of neural circuits is highly structured, lateral inhibition sharpens contrast among stimulus properties. The…

The influence of the synaptic channel properties on the stability of delayed activity maintained by recurrent neural network is studied. The duration of excitatory post-synaptic current (EPSC) is shown to be essential for the global…

Neuronal avalanches, measured in vitro and in vivo, exhibit a robust critical behaviour. Their temporal organization hides the presence of correlations. Here we present experimental measurements of the waiting time distribution between…

Inhibitory neurons play a crucial role in maintaining persistent neuronal activity. Although connected extensively through electrical synapses (gap-junctions), these neurons also exhibit interactions through chemical synapses in certain…

A widely accepted view of computations in the brain relies on population coding, where the neural ensemble firing rate is modulated in a stable manner to transmit information and perform various cognitive tasks. At the same time,…

Background: In patients with psychotic disorders, sleep spindles are reduced, supporting the hypothesis that the thalamus and glutamate receptors play a crucial etio-pathophysiological role, whose underlying mechanisms remain unknown. We…

A pre-synaptic neuron releases diffusing neurotransmitters such as glutamate that activate post-synaptic receptors. The amplitude of the post-synaptic current, mostly mediated by glutamatergic (AMPARs) receptors, is a fundamental signal…

In vitro and in vivo spiking activity clearly differ. Whereas networks in vitro develop strong bursts separated by periods of very little spiking activity, in vivo cortical networks show continuous activity. This is puzzling considering…