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Personalized medicine has received increasing attention among statisticians, computer scientists, and clinical practitioners. A major component of personalized medicine is the estimation of individualized treatment rules (ITRs). Recently,…

统计方法学 · 统计学 2015-08-14 Xin Zhou , Nicole Mayer-Hamblett , Umer Khan , Michael R. Kosorok

Personalized medicine aims to tailor treatments to individual patients, especially when people respond heterogeneously to therapies. A key objective is to learn individualized treatment rules that recommend optimal treatments from patient…

统计方法学 · 统计学 2026-03-12 Zhu Wang

One of the primary goals of statistical precision medicine is to learn optimal individualized treatment rules (ITRs). The classification-based, or machine learning-based, approach to estimating optimal ITRs was first introduced in…

统计方法学 · 统计学 2024-06-18 Sophia Yazzourh , Nikki L. B. Freeman

Dynamic treatment regimens (DTRs) are sequential decision rules tailored at each stage by potentially time-varying patient features and intermediate outcomes observed in previous stages. The complexity, patient heterogeneity and chronicity…

统计方法学 · 统计学 2016-11-09 Ying Liu , Yuanjia Wang , Michael R. Kosorok , Yingqi Zhao , Donglin Zeng

We present a novel adaptive online learning (AOL) framework to predict human movement trajectories in dynamic video scenes. Our framework learns and adapts to changes in the scene environment and generates best network weights for different…

计算机视觉与模式识别 · 计算机科学 2020-08-31 Manh Huynh , Gita Alaghband

Precision medicine is an emerging scientific topic for disease treatment and prevention that takes into account individual patient characteristics. It is an important direction for clinical research, and many statistical methods have been…

统计方法学 · 统计学 2017-02-17 Jingxiang Chen , Haoda Fu , Xuanyao He , Michael R. Kosorok , Yufeng Liu

To promote precision medicine, individualized treatment regimes (ITRs) are crucial for optimizing the expected clinical outcome based on patient-specific characteristics. However, existing ITR research has primarily focused on scenarios…

统计方法学 · 统计学 2024-02-20 Chang Wang , Lu Wang

Ordinal learning (OL) is a type of machine learning models with broad utility in health care applications such as diagnosis of different grades of a disease (e.g., mild, modest, severe) and prediction of the speed of disease progression…

机器学习 · 计算机科学 2023-12-18 Lujia Wang , Hairong Wang , Yi Su , Fleming Lure , Jing Li

Estimating optimal individualized treatment rules (ITRs) via outcome weighted learning (OWL) often relies on observed rewards that are noisy or optimistic proxies for the true latent utility. Ignoring this reward uncertainty leads to the…

机器学习 · 计算机科学 2026-04-03 Yuya Ishikawa , Shu Tamano

Many scientific questions require estimating the effects of continuous treatments. Outcome modeling and weighted regression based on the generalized propensity score are the most commonly used methods to evaluate continuous effects.…

统计方法学 · 统计学 2019-10-29 Nathan Kallus , Michele Santacatterina

Inspired by the recent successes of Inverse Optimization (IO) across various application domains, we propose a novel offline Reinforcement Learning (ORL) algorithm for continuous state and action spaces, leveraging the convex loss function…

机器学习 · 计算机科学 2026-03-19 Ioannis Dimanidis , Tolga Ok , Peyman Mohajerin Esfahani

We provide a novel characterization of augmented balancing weights, also known as automatic debiased machine learning (AutoDML). These popular doubly robust or de-biased machine learning estimators combine outcome modeling with balancing…

统计方法学 · 统计学 2024-06-07 David Bruns-Smith , Oliver Dukes , Avi Feller , Elizabeth L. Ogburn

When estimating causal effects from observational data with numerous covariates, employing penalized covariate selection can improve the estimation efficiency. Outcome-oriented covariate selection, which involves selecting covariates…

统计方法学 · 统计学 2025-01-14 Wataru Hongo , Shuji Ando , Jun Tsuchida , Takashi Sozu

This paper presents a model-free reinforcement learning (RL) algorithm to solve the risk-averse optimal control (RAOC) problem for discrete-time nonlinear systems. While successful RL algorithms have been presented to learn optimal control…

系统与控制 · 电气工程与系统科学 2021-03-29 Yuzhen Han , Majid Mazouchi , Subramanya Nageshrao , Hamidreza Modares

When applying offline reinforcement learning (RL) in healthcare scenarios, the out-of-distribution (OOD) issues pose significant risks, as inappropriate generalization beyond clinical expertise can result in potentially harmful…

机器学习 · 计算机科学 2025-05-23 Runze Yan , Xun Shen , Akifumi Wachi , Sebastien Gros , Anni Zhao , Xiao Hu

Forecast-then-optimize is a widely-used framework for decision-making problems in power systems. Traditionally, statistical losses have been employed to train forecasting models, but recent research demonstrated that improved decision…

系统与控制 · 电气工程与系统科学 2023-12-22 Haipeng Zhang , Ran Li , Mingyang Sun , Teng Fei

In modern biomedical and econometric studies, longitudinal processes are often characterized by complex time-varying associations and abrupt regime shifts that are shared across correlated outcomes. Standard functional data analysis (FDA)…

统计方法学 · 统计学 2026-01-28 Baolin Chen , Mengfei Ran

In this paper, we consider the problem of predicting unknown targets from data. We propose Online Residual Learning (ORL), a method that combines online adaptation with offline-trained predictions. At a lower level, we employ multiple…

系统与控制 · 电气工程与系统科学 2024-09-10 Anastasios Vlachos , Anastasios Tsiamis , Aren Karapetyan , Efe C. Balta , John Lygeros

Transfer learning is an emerging paradigm for leveraging multiple sources to improve the statistical inference on a single target. In this paper, we propose a novel approach named residual importance weighted transfer learning (RIW-TL) for…

统计方法学 · 统计学 2024-01-04 Junlong Zhao , Shengbin Zheng , Chenlei Leng

Offline Reinforcement Learning (RL), which operates solely on static datasets without further interactions with the environment, provides an appealing alternative to learning a safe and promising control policy. The prevailing methods…

机器学习 · 计算机科学 2025-03-18 Kun Wu , Yinuo Zhao , Zhiyuan Xu , Zhengping Che , Chengxiang Yin , Chi Harold Liu , Feiferi Feng , Jian Tang
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