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Foundation models have shown remarkable success in fitting biological visual systems; however, their black-box nature inherently limits their utility for understanding brain function. Here, we peek inside a SOTA foundation model of neural…

神经元与认知 · 定量生物学 2025-12-10 Johannes Bertram , Luciano Dyballa , T. Anderson Keller , Savik Kinger , Steven W. Zucker

Understanding the modularity of fMRI-derived brain networks or connectomes can inform the study of brain function organization. However, fMRI connectomes additionally involve negative edges, which are not rigorously accounted for by…

Partial synchronization plays a crucial role in the functioning of neuronal networks: selective, coordinated activation of neurons enables information processing that flexibly adapts to a changing computational context. Since the structure…

神经元与认知 · 定量生物学 2025-06-17 Daniil Radushev , Olesia Dogonasheva , Boris Gutkin , Denis Zakharov

Understanding the relationship between the dynamics of neural processes and the anatomical substrate of the brain is a central question in neuroscience. On the one hand, modern neuroimaging technologies, such as diffusion tensor imaging,…

Patterns of brain activity are associated with different brain processes and can be used to identify different brain states and make behavioral predictions. However, the relevant features are not readily apparent and accessible. To mine…

Higher brain function relies upon the ability to flexibly integrate information across specialized communities of brain regions, however it is unclear how this mechanism manifests over time. In this study, we use time-resolved network…

Experiments that study neural encoding of stimuli at the level of individual neurons typically choose a small set of features present in the world --- contrast and luminance for vision, pitch and intensity for sound --- and assemble a…

机器学习 · 统计学 2016-11-22 Xin , Chen , Jeffrey M Beck , John M Pearson

The identification of unlabelled neuronal electric signals is one of the most challenging open problems in neuroscience, widely known as Spike Sorting. Motivated to solve this problem, we propose a model-based approach within the mixture…

应用统计 · 统计学 2022-03-14 Alejandro Rodríguez-Collado , Cristina Rueda

Background: Current neuronal monitoring techniques, such as calcium imaging and multi-electrode arrays, enable recordings of spiking activity from hundreds of neurons simultaneously. Of primary importance in systems neuroscience is the…

神经元与认知 · 定量生物学 2014-11-11 Yazan N. Billeh , Michael T. Schaub , Costas A. Anastassiou , Mauricio Barahona , Christof Koch

Functional magnetic resonance imaging (fMRI) aims to locate activated regions in human brains when specific tasks are performed. The conventional tool for analyzing fMRI data applies some variant of the linear model, which is restrictive in…

统计理论 · 数学 2008-08-08 Chunming Zhang , Tao Yu

Scientific studies have shown that non-conscious stimuli and representations influence information processing during conscious experience. In the light of such evidence, questions about potential functional links between non-conscious brain…

神经元与认知 · 定量生物学 2018-05-24 Birgitta Dresp-Langley

In the fields of computation and neuroscience, much is still unknown about the underlying computations that enable key cognitive functions including learning, memory, abstraction and behavior. This paper proposes a mathematical and…

人工智能 · 计算机科学 2025-01-14 Jeet Singh

Population-wide oscillations are ubiquitously observed in mesoscopic signals of cortical activity. In these network states a global oscillatory cycle modulates the propensity of neurons to fire. Synchronous activation of neurons has been…

神经元与认知 · 定量生物学 2017-07-04 Tobias Kühn , Moritz Helias

Functional magnetic resonance imaging (fMRI) has provided invaluable insight into our understanding of human behavior. However, large inter-individual differences in both brain anatomy and functional localization after anatomical alignment…

应用统计 · 统计学 2021-11-03 Guoqing Wang , Abhirup Datta , Martin A. Lindquist

Sensory perception originates from the responses of sensory neurons, which react to a collection of sensory signals linked to various physical attributes of a singular perceptual object. Unraveling how the brain extracts perceptual…

神经元与认知 · 定量生物学 2025-10-27 Zhichao Zhu , Yang Qi , Wenlian Lu , Jianfeng Feng

In the last century, most sensorimotor studies of cortical neurons relied on average firing rates. Rate coding is efficient for fast sensorimotor processing that occurs within a few seconds. Much less is known about the neural mechanisms…

神经元与认知 · 定量生物学 2026-05-01 Terrence J. Sejnowski

Fluorescence is a powerful mean to probe information processing in the mammalian brain. However, neuronal tissues are highly heterogeneous and thus opaque to light. A wide set of non-invasive or invasive techniques for scattered light…

光学 · 物理学 2020-05-11 Claudio Moretti , Sylvain Gigan

Converging evidence indicates that the heterogeneity of cognitive profiles may arise through detectable alternations in brain functions. Particularly, brain functional connectivity, measured under resting and cognitive states, characterizes…

应用统计 · 统计学 2023-02-22 Tianqi Chen , Chichun Tan , Hongyu Zhao , Todd Constable , Sarah Yip , Yize Zhao

In the past five years, the use of generative and foundational AI systems has greatly improved the decoding of brain activity. Visual perception, in particular, can now be decoded from functional Magnetic Resonance Imaging (fMRI) with…

图像与视频处理 · 电气工程与系统科学 2024-03-15 Yohann Benchetrit , Hubert Banville , Jean-Rémi King

Community detection for time series without prior knowledge poses an open challenge within complex networks theory. Traditional approaches begin by assessing time series correlations and maximizing modularity under diverse null models.…

社会与信息网络 · 计算机科学 2023-11-13 Marco Gregnanin , Johannes De Smedt , Giorgio Gnecco , Maurizio Parton