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Segmentation of lymphoma lesions is challenging due to their varied sizes and locations in whole-body PET scans. This work presents a fully-automated segmentation technique using a multi-center dataset of diffuse large B-cell lymphoma…

Accurate segmentation of macular edema, a hallmark pathological feature in vision-threatening conditions such as age-related macular degeneration and diabetic macular edema, is essential for clinical diagnosis and management. To overcome…

Accurate segmentation for medical images is important for clinical diagnosis. Existing automatic segmentation methods are mainly based on fully supervised learning and have an extremely high demand for precise annotations, which are very…

A fully automatic technique for segmenting the liver and localizing its unhealthy tissues is a convenient tool in order to diagnose hepatic diseases and assess the response to the according treatments. In this work we propose a method to…

The ability to extrapolate gene expression dynamics in living single cells requires robust cell segmentation, and one of the challenges is the amorphous or irregularly shaped cell boundaries. To address this issue, we modified the U-Net…

Recently, the state-of-art models for medical image segmentation is U-Net and their variants. These networks, though succeeding in deriving notable results, ignore the practical problem hanging over the medical segmentation field:…

Deep neural networks (DNNs) have been widely used for medical image analysis. However, the lack of access a to large-scale annotated dataset poses a great challenge, especially in the case of rare diseases, or new domains for the research…

Deep convolutional neural network (CNN) achieves remarkable performance for medical image analysis. UNet is the primary source in the performance of 3D CNN architectures for medical imaging tasks, including brain tumor segmentation. The…

We present a cascade deep neural network to segment retinal vessels in volumetric optical coherence tomography (OCT). Two types of knowledge are infused into the network for confining the searching regions. (1) Histology. The retinal…

Pathological diagnosis is the gold standard for cancer diagnosis, but it is labor-intensive, in which tasks such as cell detection, classification, and counting are particularly prominent. A common solution for automating these tasks is…

Nucleus image segmentation is a crucial step in the analysis, pathological diagnosis, and classification, which heavily relies on the quality of nucleus segmentation. However, the complexity of issues such as variations in nucleus size,…

The presence of drusen is the main hallmark of early/intermediate age-related macular degeneration (AMD). Therefore, automated drusen segmentation is an important step in image-guided management of AMD. There are two common approaches to…

Residual network (ResNet) and densely connected network (DenseNet) have significantly improved the training efficiency and performance of deep convolutional neural networks (DCNNs) mainly for object classification tasks. In this paper, we…

Deep Neural Networks (DNN) have been widely used to carry out segmentation tasks in both electron and light microscopy. Most DNNs developed for this purpose are based on some variation of the encoder-decoder type U-Net architecture, in…

Automated brain tumour segmentation has the potential of making a massive improvement in disease diagnosis, surgery, monitoring and surveillance. However, this task is extremely challenging. Here, we describe our automated segmentation…

Segmentation of the airway tree from chest computed tomography (CT) images is critical for quantitative assessment of airway diseases including bronchiectasis and chronic obstructive pulmonary disease (COPD). However, obtaining an accurate…

Until now, in the wake of the COVID-19 pandemic in 2019, lung diseases, especially diseases such as lung cancer and chronic obstructive pulmonary disease (COPD), have become an urgent global health issue. In order to mitigate the goal…

Projection map (PM) from optical coherence tomography (OCT) B-scan is an important tool to diagnose retinal diseases, which typically requires retinal layer segmentation. In this study, we present a novel end-to-end framework to predict PMs…

Organ at risk (OAR) segmentation is a crucial step for treatment planning and outcome determination in radiotherapy treatments of cancer patients. Several deep learning based segmentation algorithms have been developed in recent years,…

Recent advances of semantic image segmentation greatly benefit from deeper and larger Convolutional Neural Network (CNN) models. Compared to image segmentation in the wild, properties of both medical images themselves and of existing…